Banned Agonists

In the new hemp bill, banned is “(C) Any chemical derived from a plant of the genus Cannabis that is a CB–1 or CB–2 receptor agonist or partial agonist.”

This is a list of endocannabinoids (made by the body) that are agonists:

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Industrial and Therapeutic Applications of Hemp: A Review May 27, 2026
Hemp (Cannabis sativa L.) is a multipurpose crop with significant industrial and therapeutic potential. This article reviews the various uses of hemp in production, building, food, cosmetics and medicine, focusing on its economic, environmental and health benefits. Industrially, hemp has been used for making fabrics, paper, bioplastics, construction materials and biofuels, because of its strong […]
Mechanistic Pathways Linking Cannabidiol, Hemp Seed Oil and Black Sesame Oil in Hyperarousal Insomnia: A Narrative Review April 24, 2026
Insomnia is increasingly recognized as a manifestation of multisystem dysregulation characterized by sustained physiological hyperarousal. This review situates insomnia within a framework of reciprocal disturbances across neuroendocrine, inflammatory, and autonomic pathways. It examines the potential roles of cannabidiol (CBD), polyunsaturated fatty acids (PUFAs) derived from hemp seed oil (HSO), and lignans from black sesame oil […]
Oral Cannabidiol in the Treatment of Myofascial Pain Disorder of the Temporomandibular Region: A Placebo-Controlled Randomized Clinical Trial April 22, 2026
CONCLUSION: Both CBD and hemp seed oil did appear to improve jaw function over time, but neither treatment improved pain.
Cannabidiol hinders lipopolysaccharide-induced neutrophils migration to the lungs through suppressing nuclear factor kappa-B signal and expression of interleukin-1 beta in macrophages April 5, 2026
CONCLUSION: CBD at 50 mg/kg significantly attenuates LPS-induced pulmonary inflammation and markedly suppresses the LPS-induced elevation in the number of neutrophils and interstitial macrophages in the lung. CBD could directly inhibit the expression of vascular cell adhesion molecule 1 in pulmonary endothelial cells and indirectly inhibit it by suppressing interleukin-1 beta secretion from macrophages, thereby […]
Qualitative and quantitative analysis of rat liver sinusoids under condition of a long-term experimental exposure to cannabidiol oil February 1, 2026
CONCLUSION: Conclusions: Histological, immunohistochemical study with quantitative analysis of the cellular composition of rat liver sinusoids indicates the safety of long-term experimental exposure to CBD oil.
Determination of cannabinoids in commercial hemp seeds and hemp seed oil products in Turkiye by LC-MS/MS February 1, 2026
Hemp seeds and hemp seed oil are consumed both as cosmetics and as dietary supplements. Many countries have implemented legal regulations establishing thresholds for cannabinoids, particularly Δ9-tetrahydrocannabinol (Δ9-THC), in hemp seeds and hemp seed oil. This study presents the development and validation of a LC-MS/MS method for the quantitative determination of Δ9-tetrahydrocannabinol (Δ9-THC), Δ8-tetrahydrocannabinol (Δ8-THC), […]
In vitro digestion and cytotoxicity study of cannabidiol-loaded nanostructured lipid carriers December 8, 2025
Cannabidiol (CBD), a lipophilic compound with promising health benefits, such as analgesic, anti-inflammatory and neuroprotective effects, is characterized by low oral bioavailability, which limit its therapeutic application. To address these limitations, CBD was incorporated into nanostructured lipid carriers (NLCs), either as CBD-rich extract (CBD(ext)) or as an isolate (CBD(iso)). The resulting systems - NLC-CBD(ext) and […]
Adipogenicity-induced human mesenchymal stem cells treated with hemp seed oil stimulate brown-like adipocytes and decrease adipokine levels through the activation of cannabinoid receptor 2 (CB2) November 19, 2025
The endocannabinoid system (ECS) is essential for energy hemostasis, obesity, and other metabolic disorders. Cannabidiol and polyunsaturated fatty acids (PUFAs), which are found in hemp seed oil (HSO), have been found to regulate adipose tissue through the ECS. Thus, human mesenchymal stem cells (hMSCs) were differentiated into pre-adipocytes and then treated with cannabidiol (CBD), tetrahydrocannabinol […]
Unlocking safety: a mathematical model and selective extraction for delta9-THC removal from hemp seed husks November 18, 2025
Among the myriad components found in marijuana, cannabis, and hemp, cannabidiol (CBD), delta 9-tetrahydrocannabinol (Δ9-THC), cannabinol (CBN), cannabigerol (CBG), and other cannabinoids have long been utilized. However, controversies persist regarding the addictive and hallucinogenic effects of Δ9-THC, CBN, and hexahydrocannabihexol (HHCH) in various countries, contrasting with the positive attributes associated with CBD and CBG. Ongoing […]
Anti-obesity effect of unsaponifiable matter from hemp seed in 3T3-L1 adipocytes and high-fat diet-induced obese mice October 6, 2025
The favorable lipid profile of hemp seed could be a potential source of unsaponifiable matter rich in fat-soluble phytochemicals such as phytosterols, vitamin E, and cannabidiol (CBD). Despite its nutritional value, studies investigating the functional properties of hemp seed, particularly its anti-obesity potential, remain limited. The aim of this study was to obtain unsaponifiable matter […]