Hemp History

“Humphrey Ploughjogger”

June is Hemp History Month. “Humphrey Ploughjogger” was a pseudonym or nom de plume of founding father John Adams, the second U.S. President. The Humphrey Ploughjogger letters are in an American tradition of humor that arises from illiterate phonetic spelling and rustic dialect, and that is meant to cover an undertone of serious purpose. From … Continue reading "“Humphrey Ploughjogger”" ...

“Americanize” New Foods in Order to be Literally and Culturally Palatable

In the 1980s, in order to normalize Soyfoods which are foods made out of tofu or soymilk, I offered them in traditional American flavors and forms. Cottage Salad, soymilk, dips like Missing-Egg Salad and Tofummus, Soy-o yogurt, chocolate and strawberry puddings (Bill Cosby was big then), but also brands like LeTofu (similar to ice cream), … Continue reading "“Americanize” New Foods in Order to be Literally and Culturally Palatable" ...

“Empirical THC Testing”

Here’s a scene from Dave Olson’s 1997 documentary “The Hempen Road” featuring hemp food pioneer Dr Jace Callaway of FINOLA talking about how he tested the crop for THC, much to the surprise of police. Filmed at the Vancouver Hemp Symposium. 1:49 Copyright 1997 Dave Olson ...

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A case report of CBD and THC as analgesic therapy in a cat with chronic osteoarthritic pain April 1, 2023
A 10-year-old mixed breed male cat presented with clinical signs related to chronic orthopaedic pain. Upon physical examination, pain was noted, based on the feline Musculoskeletal Pain Index (FMPI). An analgesic treatment with a full spectrum cannabis oil (1.8% CBD and 0.8% THC) was proposed for 30 days (0,5 mg/kg based on CBD). The FMPI […]
E Gutierre
Income inequality and daily use of cannabis, cigarettes, and e-cigarettes among Canadian secondary school students: Results from COMPASS 2018-19 April 1, 2023
INTRODUCTION: Cannabis, cigarette, and e-cigarette use among Canadian adolescents is a major public health concern. Income inequality has been associated with adverse mental health among youth and may contribute to the risk of frequent cannabis, cigarette, and e-cigarette use. We tested the association between income inequality and the risk of daily cannabis, cigarette, and e-cigarette […]
Claire Benny
Differential effect of cannabis use on opioid agonist treatment outcomes: Exploratory analyses from the OPTIMA study April 1, 2023
CONCLUSIONS: The current study did not demonstrate a statistically significant effect of cannabis use on outcomes of interest in the context of a pragmatic randomized-controlled trial. These findings replicated previous results reporting no effect of cannabis use on opioid-related outcomes.
Laurent Elkrief
Can we predict the treatment doses of THC and CBD and does it matter? April 1, 2023
CONCLUSION: Models based on patient characteristics failed to accurately predict the final titration doses of CBD and THC for both inhalation and sublingual administration. Clinical guidelines should maintain a highly individual approach for cannabinoid dosing.
Nitzan Halamish
Cannabis Use and Symptomatic Relapse in First Episode Schizophrenia: Trigger or Consequence? Data From the OPTIMISE Study March 31, 2023
CONCLUSIONS: In patients in remission from their first episode of schizophrenia, schizophreniform, or schizoaffective disorder, cannabis use increases the rate of relapse in both compliant and noncompliant individuals. Importantly, the temporal relationship between cannabis and relapse was that cannabis use preceded later relapse, noncompliance, and decrease in social functioning, and not that patients began to […]
Linda Levi
Vaping Induced Cannabidiol (CBD) Oxidation Product CBD Quinone Forms Protein Adducts with KEAP1 and Activates KEAP1-Nrf2 Genes March 31, 2023
Cannabidiol (CBD) vaping products have become widely available in the U.S. since their legalization in 2018. However, little is known about their respiratory health effects. Here we show that aerosolization of commercial CBD vaping products generates a reactive CBD quinone (CBDQ) which forms adducts with protein cysteine residues. Using click chemistry and a novel in […]
Charlotte A Love
Cannabis update: Anxiety disorders and post-traumatic stress disorder March 31, 2023
The development of anxiety disorders and post-traumatic stress disorder (PTSD) is complex. Both delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are of potential therapeutic use. Evidence suggests that cannabis has a beneficial effect on neural circuitry involved in fear regulation. In the United States, cannabis is considered either medical or recreational and can contain pure THC or […]
Amy L Haycraft
Association between Substance Misuse and Outcomes in Critically III Patients with Pneumonia March 31, 2023
Rationale: In patients with pneumonia requiring intensive care unit (ICU) admission, alcohol misuse is associated with increased mortality, but the relationship between other commonly misused substances and mortality is unknown. Objectives: We sought to establish whether alcohol misuse, cannabis misuse, opioid misuse, stimulant misuse, or misuse of more than one of these substances was associated […]
Paul M Reynolds
Implications of Cannabis Legalization on Substance-Related Benefits and Harms for People Who Use Opioids: A Canadian Perspective March 31, 2023
In 2018, Canada enacted the Cannabis Act, becoming only the second country (after Uruguay) to legalize the recreational consumption of cannabis. Although there is ongoing global disagreement on the risk-benefit profile of cannabis with increasing legalization in many parts of the world, the evidence of rising cannabis use prevalence postlegalization has been consistent. In contrast, […]
Anees Bahji
Alcohol-induced blackouts among college student drinkers: A multilevel analysis March 31, 2023
CONCLUSION: We identified a number of daily-, weekly-, and person-level factors that uniquely contribute to the prediction of AIBs even at equivalent eBACs. Many of these factors were behavioral, suggesting that they may serve as malleable prevention targets for AIBs in college student drinkers.
Veronica L Richards
The Relations Between an Inventory-Based Measure of Executive Function and Impulsivity Factors in Alcohol- and Cannabis-Relevant Outcomes March 31, 2023
CONCLUSIONS: Overall, this study suggested substantial overlap between impulsigenic factors and EFs when measured by self-report, and limited utility of EF measures to account for unique variance with substance use outcomes in this sample.
Jeffrey T Cooke
Role of Neuronal Nicotinic Acetylcholine Receptors in Cannabinoid Dependence March 31, 2023
Cannabis is among the most widely consumed psychoactive drugs around the world and cannabis use disorder (CUD) has no current approved pharmacological treatment. Nicotine and cannabis are commonly co-used which suggests there to be overlapping neurobiological actions supported primarily by the co-distribution of both receptor systems in the brain. There appears to be strong rationale […]
B Buzzi
Solubility enhancement and antioxidation maintenance of CBD encapsulated in the P407-RUB nano-micelle system March 31, 2023
CONCLUSION: These results suggest that CBD-M may be a promising and competitive formulation for the delivery of CBD, laying a foundation for improving the bioavailability in the future.
Yan-Ting Su
Bakuchiol and Ethyl (Linoleate/Oleate) Synergistically Modulate Endocannabinoid Tone in Keratinocytes and Repress Inflammatory Pathway mRNAs March 30, 2023
The endocannabinoid (eCB) system plays an active role in epidermal homeostasis. Phytocannabinoids such as cannabidiol modulate this system but also act through eCB-independent mechanisms. This study evaluated the effects of cannabidiol, bakuchiol (BAK), and ethyl (linoleate/oleate) (ELN) in keratinocytes and reconstituted human epidermis. Molecular docking simulations showed that each compound binds the active site of […]
William R Swindell
Metabolic memory of Δ9-tetrahydrocannabinol exposure in pluripotent stem cells and primordial germ cells-like cells March 30, 2023
Cannabis, the most consumed psychoactive drug in the world, is increasingly used by pregnant women. However, while cannabinoid receptors are expressed in the early embryo, the impact of phytocannabinoids exposure on early embryonic processes is lacking. Here, we leverage a stepwise in vitro differentiation system that captures early embryonic developmental cascade to investigate the impact […]
Roxane Verdikt
A Video Segmentation Pipeline for Assessing changes in Pupil Response to Light After Cannabis Consumption March 30, 2023
Due to long-standing federal restrictions on cannabis-related research, the implications of cannabis legalization on traffic and occupational safety are understudied. Accordingly, there is a need for objective and validated measures of acute cannabis impairment that may be applied in public safety and occupational settings. Pupillary response to light may offer an avenue for detection that […]
Benjamin Steinhart
Cannabis vaping among high school seniors in adult-use, medical, and prohibited legal contexts March 30, 2023
CONCLUSION: These results contribute knowledge about contextual factors related to adolescent cannabis vaping, a relatively new technique of cannabis consumption for which there is growing societal concern.
Christian P Maynard
Old Dog, New Tricks: A Review of Identifying and Addressing Youth Cannabis Vaping in the Pediatric Clinical Setting March 30, 2023
Cannabis vaping has emerged as a predominant mode of cannabis use among United States (US) adolescents and young adults (AYA) primarily due to the popularity of modifiable designs of vaping devices coupled with changes in cannabis policies and increased availability of cannabinoid products. New methods for cannabis vaping by e-liquid/oil vaping, dry plant vaping, and […]
Pravesh Sharma
Substance Use Outcomes For Sexual and Gender Minority Adults With a History of Adverse Childhood Experiences: A Scoping Review March 30, 2023
CONCLUSIONS: Longitudinal research is needed to comprehend the impact of ACE on SU within the diverse subgroups of SGM adults. Investigators should prioritize the use of standard operationalizations of ACE and SU to improve comparability across studies and include diverse samples from the SGM community.
Brockton A Dowling
Nationally representative surveys on cannabis use lack product details relevant to public health March 30, 2023
CONCLUSIONS: Cannabis consumers employ multiple consumption modes, and product type cannot be inferred from mode of use. With THC potencies markedly higher in concentrates, these findings underscore the importance of including information on cannabis product types and mode of use in surveillance surveys. Clinicians and policymakers need these data to inform treatment decisions and assess […]
Sarah Stith