Cannabigerol and cannabidiol differ in their ability to affect the AhR/CYP1A pathway in vitro
Cannabidiol (CBD) is known to activate aryl hydrocarbon receptor (AhR) and expression of cytochromes P450 (CYP) 1A. This study examined the effect of cannabigerol (CBG)...
Phytochemistry-Guided Green Synthesis of Antimicrobial Silver Nanoparticles from Cannabis sativa Chemovars
The phytochemical variability in Cannabis sativa L. chemovars represents an underexplored factor in environmentally sustainable nanomaterial production. In this study, three distinct chemovars, (i) High-Δ⁹-Tetrahydrocannabinol...
Multielement Analysis of Selected Superfood Seeds and Grains Using ICP-OES: Sources of Essential and Toxic Elements
The term 'superfoods' refers to a rapidly expanding group of food products that have gained increasing global interest due to their high nutritional value and...
Cannabidiol and other non-psychotropic cannabinoids from Cannabis sativa as therapeutics for microglial-mediated neuroinflammation and neurodegeneration
Non-psychotropic phytocannabinoids produced by Cannabis sativa, including cannabidiol, cannabigerol, cannabichromene and their varin and acidic analogs, are emerging as promising modulators of neuroinflammation, particularly through...
Unraveling approaches for cannabidiol delivery nanosystems: A patent review
CONCLUSION: Patented nanocarriers demonstrate potential to improve CBD delivery and stability. However, these findings should be interpreted as technological propositions rather than validated pharmacological evidence...
Phosphorus-solubilizing bacteria and phosphorus-enriched biochar enhance growth, cannabinoid content, and essential oil yield in salt-stressed hemp (Cannabis
Soil salinity induces phosphorus (P) deficiency, limiting crop productivity, yet the combined use of phosphorus-solubilizing bacteria (PSB) and phosphorus-enriched biochar (P-biochar) under salinity remains unexplored...
Assessing the relationship between technical efficiency and net carbon balance in industrial hemp production systems in Turkey
With the encouragement of international climate agreements, scientific and economic communities are increasingly seeking innovative strategies to reduce greenhouse gas emissions. This study aims to...
Health characteristics of recreationally active female cannabidiol users: a real-world cross-sectional study
INTRODUCTION: Cannabidiol (CBD) use has increased substantially in the United States alongside expanding legalization of cannabis and hemp-derived products. CBD is widely marketed for recovery...
The impact of cannabigerol exposure on human endometrial stromal cells decidualization
Decidualization denotes the inflammatory reprogramming of endometrial stromal cells (EnSC) into progesterone-dependent decidual cells (DC), a process essential for embryo implantation and placenta formation. Decidualization...
Cannabinoids in autoimmune diseases: mechanistic insights and translational challenges
Cannabinoids are traditionally recognized for their effect on the nervous system. Emerging evidence suggests that cannabinoids mitigate inflammation driven by Th1/Th17 responses, which are linked...
New terpenyl-cinnamoyl-hydrazone analogues of cannabidiol with potent antinociceptive effect
In this study, novel terpenyl-cinnamoyl-hydrazone analogs were synthesized and evaluated for antinociceptive potential in preclinical nociception models. The compounds were tested in chemical (formalin-induced licking)...
Assessment of nutritional and functional profile of whole, hulled and germinated hemp (Cannabis sativa L.) seeds
Hemp seeds (Cannabis sativa L.) have received considerable attention due to their nutrient and phytochemical content. However, while the nutritional and functional profile of whole...
Edible Cannabis and Pain, Sleep, and Mental Health Management in Older Adults
CONCLUSIONS AND RELEVANCE: In this qualitative study, older adults were motivated to use cannabis as an alternative approach to address health concerns. These findings highlight...
Concurrent use of ketogenic diet therapy and cannabidiol in children and adults with epilepsy: A multicenter retrospective cohort study
Cannabidiol (CBD) and Ketogenic Diet Therapy (KDT) are evidence-based treatments for pharmacoresistant epilepsy with growing popularity in recent years. Even though CBD and KDT are...
Prevalence and Reasons for Microdosing Cannabis, Psilocybin, LSD, and MDMA Among US Adults
CONCLUSIONS: Despite remaining illegal at the federal level, a considerable number of US adults reported microdosing cannabis, psilocybin, LSD, and MDMA in their lifetime. Microdosing...
An update on cannabis products, cannabinoid content, plant type, and prices five years after legalization in Ontario, Canada
INTRODUCTION: Changing trends in legal recreational cannabis markets necessitates the continuous monitoring of important market metrics such as price, potency, type, and availability of cannabis...
Cannabinoid Therapy for Refractory Trigeminal Neuropathic Pain: Quantification of Somatosensory Alterations (QualST) by 3D Stereophotogrammetry-Two Case Reports
CONCLUSION: These cases illustrate the potential clinical relevance of cannabinoids as an adjunctive approach for refractory TNP and highlight the importance of multidimensional assessment strategies...
Acute anti-proliferative and anti-migratory effects of cannabidiol on C6 rat glioma, SH-SY5Y human neuroblastoma, and HT22 mouse hippocampal neuronal cell
CONCLUSION: Our findings confirm the sensitivity of glioma, neuroblastoma, and hippocampal neuronal cultures to CBD, providing valuable insights for further research into its therapeutic potential...