Privately Held Pot Co. Raises $55M In Deal Led By 2 Firms

Privately Held Pot Co. Raises $55M In Deal Led By 2 Firms Privately held multistate cannabis company Holistic Industries raised $55 million through a convertible note in a transaction guided by Feuerstein Kulick LLP and Stroock & Stroock & Lavan LLP, it said Tuesday. #CBD #Hemp https://www.law360.com/cannabis/articles/1383728?utm_source=rss&utm_medium=rss&utm_campaign=section May 11, 2021 8:14 pm

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Perceived Safety and Effectiveness of Cannabis and Other Types of Pain Treatments Among Adults with Chronic Noncancer Pain in U.S. States with Medical Cannabis Programs March 21, 2023
No abstract
Sarah A White
Associations Between Mother-Adolescent and Father-Adolescent Relationships and Young Adult Health March 21, 2023
CONCLUSIONS AND RELEVANCE: The findings of this cohort study suggest that adolescents' positive perceptions of their relationships with their mothers and fathers are associated with a wide range of favorable outcomes in young adulthood. Investments in improving parent-adolescent relationships may have substantial benefits for young adult population health.
Carol A Ford
Unintentional ingestion of putative delta-8 tetrahydrocannabinol by two youth requiring critical care: a case report March 21, 2023
CONCLUSIONS: As the availability of delta-8 THC increases, along with associated pediatric exposures, it is imperative for health care providers to quickly recognize and provide adequate treatment. While there is no specific antidote for THC intoxication beyond supportive care, providers can play an important role in prevention by educating parents and guardians on safe cannabis […]
Erin K Bradley
Intoxications with synthetic cannabinoids March 21, 2023
Synthetic Cannabinoid Receptor Agonists (SCRAs) are a group of New Psychoactive Substances. They are used recreationally to mimic the effects of THC in cannabis. However, THC is a partial agonist of the CB1-receptor and SCRAs are full agonists. Because of this specificity and potency serious adverse events may occur among which psychological, cardiovascular, and gastro-intestinal […]
Jolanda G Zanen
Patient Experiences With Prescription Cannabinoids in Germany: Protocol for a Mixed Methods, Exploratory, and Anonymous Web-Based Survey March 21, 2023
CONCLUSIONS: The exploratory mixed methods approach of this project is expected to provide valid and relevant data as a basis for future clinical research. The study design may be representative for a large proportion of outpatients treated with cannabinoids in the German federal states studied. It may have less bias toward social desirability and may […]
Jan Moritz Fischer
Are Drinking Cognitions Associated with Marijuana and Concurrent Alcohol and Marijuana Use among Adolescents and Young Adults? March 20, 2023
CONCLUSIONS: Findings support and extend the utility of the PWM by indicating that specific alcohol cognitions are associated with alcohol, marijuana, and CAM use in adolescents and young adults.
Ricarda K Pritschmann
Cannabidiol enhances cerebral glucose utilization and ameliorates psychopathology and cognition: A case report in a clinically high-risk mental state March 20, 2023
Adolescent individuals often present with subtle, sub-threshold psychiatric syndromes that fluctuate or persist for years. These symptoms have been classified as Clinically High-Risk mental states (CHR), negatively affecting these individuals' psychosocial development and integration by reducing performance and affecting interpersonal relations. The pathophysiological underpinnings have not been studied in detail, contributing to the current lack […]
Dagmar Koethe
The minor cannabinoid cannabigerol (CBG) is a highly specific blood biomarker of recent cannabis smoking March 20, 2023
CONCLUSION: Whole blood cannabigerol may have forensic utility as a highly specific albeit insensitive biomarker of recent cannabis smoking.
John M Rague
An exploratory follow-up study of cannabis use and decision-making under various risk conditions within adolescence March 20, 2023
CONCLUSIONS: DM under explicit risk may be a more salient risk factor for escalating CU and CU-related problems than DM under ambiguous risk. Deficits in executive functioning could partially explain the results. Findings suggest that neurocognitive development should inform prevention and intervention efforts focused on reducing CU. Given the exploratory nature of the present study, […]
Erin L Thompson
Cannabinoids in traumatic brain injury and related neuropathologies: preclinical and clinical research on endogenous, plant-derived, and synthetic compounds March 20, 2023
Traumatic brain injury is common, and often results in debilitating consequences. Even mild traumatic brain injury leaves approximately 20% of patients with symptoms that persist for months. Despite great clinical need there are currently no approved pharmaceutical interventions that improve outcomes after traumatic brain injury. Increased understanding of the endocannabinoid system in health and disease […]
Brittney R Lins
Efficient Syntheses of KLS-13019 Using Palladium Mediated Cross Couplings March 20, 2023
KLS-13019 is a structural analogue of cannabidiol, that shows improved bioavailability and potency in both preventing and reversing paclitaxel-induced neurotoxicity in vitro and in vivo. KLS-13019 was selected as a development candidate and attention was turned to development of a scalable synthesis. The original synthesis of KLS-13019 was not efficient, regioselective, or high yielding. Two […]
William A Kinney
Cognitive behavioral therapy for insomnia to reduce cannabis use: Results from a pilot randomized controlled trial March 20, 2023
CONCLUSIONS: CBTi-CB-TM is feasible, acceptable, and demonstrated preliminary efficacy for improving sleep and cannabis-related outcomes among non-treatment-seeking individuals with regular cannabis use for sleep. Although sample characteristics limit generalizability, these findings support the need for adequately powered randomized controlled trials with longer follow-up periods.
J Todd Arnedt
Cannabis Use Does Not Affect Outcomes After Total Hip Arthroplasty March 20, 2023
CONCLUSION: Self-reported cannabis use does not influence one-year outcomes after THA. Further studies are warranted to determine the efficacy and safety of perioperative cannabis use after THA to help guide orthopaedic surgeons in counseling patients.
Vishal Hegde
Incidence of cardiovascular symptoms and adverse events following self-reported acute cannabis intoxication at the emergency department: a retrospective study March 20, 2023
No abstract
Femke Gresnigt
Medical cannabis identity and public health paternalism March 20, 2023
CONCLUSIONS: The designation of medical vs. nonmedical use of cannabis varies from state to state, which is not the case for other medicine. This highly variable designation may be paternalistic in nature as governments attempt to differentiate between "legitimate" and "illegitimate" use in the context of federal cannabis prohibition. As a result, lines between medical […]
Amanda Reiman
Expression of cannabinoid (CB1 and CB2) and cannabinoid-related receptors (TRPV1, GPR55, and PPARα) in the synovial membrane of the horse metacarpophalangeal joint March 20, 2023
CONCLUSIONS AND CLINICAL IMPORTANCE: Given the expression of the CB1R, CB2R, TRPV1, GPR55, and PPARα in the synovial elements of the metacarpophalangeal joint, these findings encouraged the development of new studies supporting the use of molecules acting on these receptors to reduce the inflammation during joint inflammation in the horse.
Rodrigo Zamith Cunha
Consuming oral cannabidiol prior to a standard alcohol dose has minimal effect on breath alcohol level and subjective effects of alcohol March 20, 2023
CONCLUSIONS: CBD has minimal influence on BrAC and subjective effects of alcohol. Further research is needed to test whether CBD impacts alcohol consumption in humans, and if so, what mechanism(s) may explain this effect.
Hollis C Karoly
Autophagy: An Emerging Target for Developing Effective Analgesics March 20, 2023
Inadequate treatment of acute and chronic pain causes depression, anxiety, sleep disturbances, and increased mortality. Abuse and overdose of opioids and the side effects associated with chronic use of NSAID illustrate the need for development of safer and effective pain medication. Working toward this end, an in silico tool based on an emergent intelligence analytical […]
Palaniyandi Manivasakam
Associations of cannabis use with motor vehicle crashes and traffic stops among older drivers: AAA LongROAD study March 20, 2023
CONCLUSIONS: Past-year cannabis use was associated with increased traffic stops, which are correlated modestly with increased MVC in past studies and may indicate impaired driving performance. We did not find a statistically significant association of past-year cannabis use with MVC, which may indicate limited sustained effects on driving performance from periodic use among older adults, […]
Shelby Davis
High-CBD Cannabis Vapor Attenuates Opioid Reward and Partially Modulates Nociception in Female Rats March 20, 2023
Chronic pain patients report analgesic effects when using cannabidiol (CBD), a phytocannabinoid found in whole-plant cannabis extract (WPE). Several studies suggest that cannabis-derived products may serve as an analgesic adjunct or alternative to opioids, and importantly, CBD may also attenuate the abuse potential of opioids. Vaping is a popular route of administration among people who […]
Maria T Rivera-Garcia