PubMed: Anti-oxidant effects of cannabidiol relevant to intracerebral hemorrhage

PubMed: Anti-oxidant effects of cannabidiol relevant to intracerebral hemorrhage

Front Pharmacol. 2023 Sep 28;14:1247550. doi: 10.3389/fphar.2023.1247550. eCollection 2023.

ABSTRACT

Intracerebral hemorrhage (ICH) is a subtype of stroke with a high mortality rate. Oxidative stress cascades play an important role in brain injury after ICH. Cannabidiol, a major non-psychotropic phytocannabinoids, has drawn increasing interest in recent years as a potential therapeutic intervention for various neuropsychiatric disorders. Here we provide a comprehensive review of the potential therapeutic effects of cannabidiol in countering oxidative stress resulting from ICH. The review elaborates on the various sources of oxidative stress post-ICH, including mitochondrial dysfunction, excitotoxicity, iron toxicity, inflammation, and also highlights cannabidiol’s ability to inhibit ROS/RNS generation from these sources. The article also delves into cannabidiol’s role in promoting ROS/RNS scavenging through the Nrf2/ARE pathway, detailing both extranuclear and intranuclear regulatory mechanisms. Overall, the review underscores cannabidiol’s promising antioxidant effects in the context of ICH and suggests its potential as a therapeutic option.

PMID:37841923 | PMC:PMC10568629 | DOI:10.3389/fphar.2023.1247550

https://pubmed.ncbi.nlm.nih.gov/37841923/?utm_source=Chrome&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1NqsX9BbHlDygQ8TcgAlJilHgPpiuKQtyIr–a3-xbLzPoB9xM&fc=20220928170152&ff=20231016190657&v=2.17.9.post6+86293ac October 16, 2023 10:00 am