PubMed: Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants

PubMed: Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants

J Nat Prod. 2022 Jan 10. doi: 10.1021/acs.jnatprod.1c00946. Online ahead of print.

ABSTRACT

As a complement to vaccines, small-molecule therapeutic agents are needed to treat or prevent infections by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and its variants, which cause COVID-19. Affinity selection-mass spectrometry was used for the discovery of botanical ligands to the SARS-CoV-2 spike protein. Cannabinoid acids from hemp (Cannabis sativa) were found to be allosteric as well as orthosteric ligands with micromolar affinity for the spike protein. In follow-up virus neutralization assays, cannabigerolic acid and cannabidiolic acid prevented infection of human epithelial cells by a pseudovirus expressing the SARS-CoV-2 spike protein and prevented entry of live SARS-CoV-2 into cells. Importantly, cannabigerolic acid and cannabidiolic acid were equally effective against the SARS-CoV-2 alpha variant B.1.1.7 and the beta variant B.1.351. Orally bioavailable and with a long history of safe human use, these cannabinoids, isolated or in hemp extracts, have the potential to prevent as well as treat infection by SARS-CoV-2.

PMID:35007072 | DOI:10.1021/acs.jnatprod.1c00946

#CBD #Hemp https://pubmed.ncbi.nlm.nih.gov/35007072/?utm_source=Chrome&utm_medium=rss&utm_campaign=None&utm_content=1jYCQzi_o_qLYr-oQfnMhShgOXkvGma3vcnBGJtrBhuJMOvEVJ&fc=None&ff=20220111060003&v=2.17.5 January 10, 2022 11:00 am