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PubMed: Cannabinoids in epilepsy: clinical efficacy and pharmacological considerations

PubMed: Cannabinoids in epilepsy: clinical efficacy and pharmacological considerations

Neurologia (Engl Ed). 2021 Nov 22:S2173-5808(21)00182-6. doi: 10.1016/j.nrleng.2020.02.012. Online ahead of print.

ABSTRACT

INTRODUCTION: Advances in the development of drugs with novel mechanisms of action have not been sufficient to significantly reduce the percentage of patients presenting drug-resistant epilepsy. This lack of satisfactory clinical results has led to the search for more effective treatment alternatives with new mechanisms of action.

DEVELOPMENT: The aim of this study is to examine epidemiological aspects of the use of cannabis-based products for the treatment of epilepsy, with particular emphasis on the main mechanisms of action, indications for use, clinical efficacy, and safety. We conducted a narrative review of articles gathered from the PubMed, EMBASE, and Google Scholar databases and from the reference sections of relevant publications.

CONCLUSIONS: In recent years there has been growing interest in the use of cannabis-based products for the treatment of a wide range of diseases, including epilepsy. The cannabis plant is currently known to contain more than 100 terpenophenolic compounds, known as cannabinoids. The 2 most abundant are delta-9-tetrahydrocannabinol and cannabidiol. Studies of preclinical models of epilepsy have shown that these cannabinoids have anticonvulsant properties, and 100% purified cannabidiol and cannabidiol-enriched cannabis extracts are now being used to treat epilepsy in humans. Several open-label studies and randomised controlled clinical trials have demonstrated the efficacy and safety of these products.

PMID:34824031 | DOI:10.1016/j.nrleng.2020.02.012

#CBD #Hemp https://pubmed.ncbi.nlm.nih.gov/34824031/?utm_source=Chrome&utm_medium=rss&utm_campaign=None&utm_content=1jYCQzi_o_qLYr-oQfnMhShgOXkvGma3vcnBGJtrBhuJMOvEVJ&fc=None&ff=20211127055846&v=2.15.0 November 26, 2021 11:00 am

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