PubMed: Cannabis and metformin on diabetic male Wistar rat sperm and reproductive organ parameters

PubMed: Cannabis and metformin on diabetic male Wistar rat sperm and reproductive organ parameters

J Diabetes Metab Disord. 2022 Jul 29;21(2):1451-1458. doi: 10.1007/s40200-022-01079-z. eCollection 2022 Dec.

ABSTRACT

PURPOSE: Cannabis use has reportedly increased in type 2 diabetic users as a possible co-treatment for associated pain and inflammation. Both cannabis and metformin (an anti-diabetic drug) have a limited number of studies completed on their effect on male reproductive parameters in a diabetic model. This study determined if cannabis and metformin administration alter various reproductive parameters in diabetic male rats.

METHODS: Male Wistar rats (n = 35) were fed on a high fat diet and injected with streptozotocin (30 mg/kg rat) to induce a type-2 diabetic model. Treatment groups received cannabis based on Delta-9-Tetrahydrocannabinol (THC) concentrations of 1.25, 2.5 and 5 mg/kg per rat and metformin (50 mg/kg) every alternate day for 10 weeks. Organ weight; serum testosterone levels and sperm count, motility, lipid peroxidation, citrate synthase and lactate dehydrogenase activities were measured.

RESULTS: Cannabis treatment induced a significant concentration dependent decrease in sperm motility at 5 mg/kg rat THC (P = 0.009) administration. Metformin significantly (P = 0.035) increased sperm counts and lactate dehydrogenase activity (P = 0.002). Both cannabis and metformin negatively affected testosterone concentrations.

CONCLUSIONS: Cannabis needs to be used cautiously as an alternative treatment in diabetic males based on the negative effects observed for the various reproductive parameters in this diabetic rat model.

PMID:36404868 | PMC:PMC9672239 | DOI:10.1007/s40200-022-01079-z

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