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PubMed: CB<sub>1</sub> receptor signalling mediates cannabidiol-induced panicolytic-like effects and defensive antinociception impairment in mice threatened by <em>Bothrops jararaca</em> lancehead pit vipers

PubMed: CB<sub>1</sub> receptor signalling mediates cannabidiol-induced panicolytic-like effects and defensive antinociception impairment in mice threatened by <em>Bothrops jararaca</em> lancehead pit vipers

J Psychopharmacol. 2022 Aug 10:2698811221115755. doi: 10.1177/02698811221115755. Online ahead of print.

ABSTRACT

BACKGROUND: Cannabis sativa-derived substances such as cannabidiol (CBD) have attracted increasing clinical interest and consist in a new perspective for treating some neurological and psychiatric diseases.

AIMS: The aim of this work was to investigate the effect of acute treatment with CBD on panic-like defensive responses displayed by mice threatened by the venomous snake Bothrops jararaca.

METHODS: Mice were habituated in the enriched polygonal arena for snake panic test. After recording the baseline responses of the tail-flick test, the prey were pretreated with intraperitoneal (i.p.) administrations of the endocannabinoid type 1 receptor (CB1) antagonist AM251 (selective cannabinoid 1 receptor antagonist with an IC50 of 8 nM) at different doses, which were followed after 10 min by i.p. treatment with CBD (3 mg/kg). Thirty minutes after treatment with CBD, mice were subjected to confrontations by B. jararaca for 5 min, and the following defensive responses were recorded: risk assessment, oriented escape behaviour, inhibitory avoidance and prey-versus-snake interactions. Immediately after the escape behaviour was exhibited, the tail-flick latencies were recorded every 5 min for 30 min.

OUTCOMES: Mice threatened by snakes displayed several anti-predatory defensive and innate fear-induced antinociception responses in comparison to the control. CBD significantly decreased the risk assessment and escape responses, with a consequent decrease in defensive antinociception. The CBD panicolytic effect was reversed by i.p. treatment with AM251.

CONCLUSIONS: These findings suggest that the anti-aversive effect of CBD depends at least in part on the recruitment of CB1 receptors.

PMID:35946605 | DOI:10.1177/02698811221115755

#CBD #Hemp https://pubmed.ncbi.nlm.nih.gov/35946605/?utm_source=Chrome&utm_medium=rss&utm_campaign=None&utm_content=1jYCQzi_o_qLYr-oQfnMhShgOXkvGma3vcnBGJtrBhuJMOvEVJ&fc=None&ff=20220810162128&v=2.17.7 August 10, 2022 10:00 am

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