PubMed: Effects of prenatal alcohol and delta-9-tetrahydrocannabinol exposure via electronic cigarettes on motor development

PubMed: Effects of prenatal alcohol and delta-9-tetrahydrocannabinol exposure via electronic cigarettes on motor development

Alcohol Clin Exp Res. 2022 Jun 20. doi: 10.1111/acer.14892. Online ahead of print.


BACKGROUND: It has been well established that prenatal alcohol exposure can lead to a wide range of neurological and behavioral deficits, including alterations in motor domains. However, much less is known about the effects of prenatal cannabis exposure on motor development, despite the fact that cannabis is the most commonly consumed illicit drug among women. Cannabis use among pregnant women has become increasingly popular given the wide-spread perception that consumption is safe during pregnancy. Moreover, alcohol and cannabis are commonly used together, even among pregnant women. Yet, few studies have explored the potential consequences of combined prenatal exposure on behavioral domains.

METHODS: Using our previously established model, pregnant Sprague-Dawley rats were exposed to one of four groups: vaporized alcohol, delta-9-Tetrahydrocannabinol (THC) via electronic (e-) cigarettes, the combination of alcohol and THC, or a vehicle from gestational days 5-20. Following birth, offspring were tested on early sensorimotor development, adolescent motor coordination, and adolescent activity levels.

RESULTS: Prenatal THC e-cigarette exposure delayed sensorimotor development early in life and impaired motor coordination later in early adolescence; combined prenatal alcohol and THC exposure did not have additive effects on sensorimotor development. However, combined prenatal exposure did produce hyperactivity among male offspring.

CONCLUSIONS: These data suggest that prenatal cannabis exposure may lead to impaired motor skills throughout early development, and that combined exposure with alcohol during gestation may also lead to hyperactivity in early adolescence. These findings have important implications for informing pregnant women of the risks associated with prenatal cannabis exposure, with and without alcohol, on the fetus and influencing related public policy.

PMID:35722858 | DOI:10.1111/acer.14892

#CBD #Hemp https://pubmed.ncbi.nlm.nih.gov/35722858/?utm_source=Chrome&utm_medium=rss&utm_campaign=None&utm_content=1jYCQzi_o_qLYr-oQfnMhShgOXkvGma3vcnBGJtrBhuJMOvEVJ&fc=None&ff=20220620065809&v=2.17.6 June 20, 2022 10:00 am

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