PubMed: Gestational exposure to cannabidiol leads to glucose intolerance in 3-month-old male offspring

PubMed: Gestational exposure to cannabidiol leads to glucose intolerance in 3-month-old male offspring

J Endocrinol. 2023 Oct 1:JOE-23-0173. doi: 10.1530/JOE-23-0173. Online ahead of print.

ABSTRACT

Reports in North America suggest that up to 20% of young women (18-24 years) use cannabis during pregnancy. This is concerning given clinical studies indicate that maternal cannabis use is associated with fetal growth restriction (FGR) and dysglycemia in the offspring. Preclinical studies demonstrated that prenatal exposure to Δ9-tetrahydrocannabinol, the main psychoactive component of cannabis, in rat dams led to female-specific deficits in β-cell mass and glucose intolerance/insulin resistance. Yet to date, the contributions of cannabidiol (CBD), the primary non-psychoactive compound in cannabis, remains elusive. This study aimed to define the effects of in utero cannabidiol (CBD) exposure on postnatal glucose regulation. Pregnant Wistar rat dams received daily intraperitoneal (i.p.) injections of either a vehicle solution or 3 mg/kg of CBD from gestational day (GD) 6 to parturition. CBD exposure did not lead to observable changes in maternal or neonatal outcomes, however by 3 months of age male CBD-exposed offspring exhibited glucose intolerance despite no changes in pancreatic β/α cell mass. Transcriptomic analysis on the livers of these CBD-exposed males revealed altered gene expression of circadian rhythm clock machinery, which is linked to systemic glucose intolerance. Alterations in hepatic developmental and metabolic processes were also observed, suggesting gestational CBD exposure has a long-lasting detrimental effect on liver health throughout life. Collectively, these results indicate that exposure to CBD alone in pregnancy may be detrimental to the metabolic health of the offspring later in life.

PMID:37855335 | DOI:10.1530/JOE-23-0173

https://pubmed.ncbi.nlm.nih.gov/37855335/?utm_source=Chrome&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1NqsX9BbHlDygQ8TcgAlJilHgPpiuKQtyIr–a3-xbLzPoB9xM&fc=20220928170152&ff=20231019190638&v=2.17.9.post6+86293ac October 19, 2023 10:00 am