PubMed: Marijuana and endothelial dysfunction: new mechanism and therapy

PubMed: Marijuana and endothelial dysfunction: new mechanism and therapy

Trends Mol Med. 2022 Jun 11:S1471-4914(22)00151-4. doi: 10.1016/j.molmed.2022.05.009. Online ahead of print.

ABSTRACT

Marijuana (cannabis) can cause cardiovascular side effects, yet the mechanisms and treatments remain poorly understood. In a recent study published in Cell, Wei et al. discovered that soy isoflavone genistein attenuates Δ9-tetrahydrocannabinol (Δ9-THC, a main constituent from marijuana)-induced endothelial dysfunction and atherosclerosis by directly antagonizing peripheral cannabinoid receptor 1, demonstrating a therapeutic potential for ameliorating the cardiovascular side effects of cannabis.

PMID:35701315 | DOI:10.1016/j.molmed.2022.05.009

#CBD #Hemp https://pubmed.ncbi.nlm.nih.gov/35701315/?utm_source=Chrome&utm_medium=rss&utm_campaign=None&utm_content=1jYCQzi_o_qLYr-oQfnMhShgOXkvGma3vcnBGJtrBhuJMOvEVJ&fc=None&ff=20220615065912&v=2.17.6 June 14, 2022 10:00 am

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