PubMed: Oxycodone Self-Administration in Female Rats is Enhanced by Δ <sup>9</sup> -tetrahydrocannabinol, but not by Cannabidiol, in a Progressive Ratio Procedure

PubMed: Oxycodone Self-Administration in Female Rats is Enhanced by Δ <sup>9</sup> -tetrahydrocannabinol, but not by Cannabidiol, in a Progressive Ratio Procedure

bioRxiv. 2023 Oct 31:2023.10.26.564282. doi: 10.1101/2023.10.26.564282. Preprint.

ABSTRACT

Epidemiological evidence suggests that the legalization of cannabis may reduce opioid-related harms. Preclinical evidence of neuropharmacological interactions of endogenous cannabinoid and opioid systems prompts further investigation of cannabinoids as potential therapeutics for the non-medical use of opioids. In these studies female rats, previously trained to self-administer oxycodone (0.15 mg/kg/infusion) intravenously in 6 h sessions, were allowed to self-administer oxycodone after exposure to cannabidiol (CBD) and Δ 9 -tetrahydrocannabinol (THC) by vapor inhalation and THC by injection (5.0-20 mg/kg, i.p.). Self-administration was characterized under Progressive Ratio (PR) and Fixed Ratio (FR) 1 schedules of reinforcement in 3 h sessions. THC decreased IVSA of oxycodone in a FR procedure but increased reward seeking in a PR procedure. CBD decreased the IVSA of oxycodone in the FR but not the PR procedure. The results are consistent with an anti-reward effect of CBD but suggest THC acts to increase the reinforcing efficacy of oxycodone in this procedure.

PMID:37961225 | PMC:PMC10634900 | DOI:10.1101/2023.10.26.564282

https://pubmed.ncbi.nlm.nih.gov/37961225/?utm_source=Chrome&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1Ds1JEbG0OWaBdqM3tTUGjkFhFGaOtMecPdpuvzbuubWi6d9Fn&fc=20231022105433&ff=20231114082202&v=2.17.9.post6+86293ac November 14, 2023 11:00 am