The role of cytochrome P450 enzyme genetic variants in cannabis hyperemesis syndrome – A case report

The role of cytochrome P450 enzyme genetic variants in cannabis hyperemesis syndrome – A case report

Basic Clin Pharmacol Toxicol. 2021 Mar 19. doi: 10.1111/bcpt.13581. Online ahead of print.

ABSTRACT

Cannabis is a complex plant including more than 400 chemicals compounds, of which more than 60 are cannabinoid compounds [1]. Cannabinoids are subjected to a significant first-pass metabolism in the liver involving the cytochrome P450 enzymes (CYP) 2C9, CYP2C19 and CYP3A4 [2];. Furthermore, CYP2J2 as the primary CYP of cardiomyocytes, is also directly involved in the metabolism of the phytocannabinoids [3]. The metabolism of tetrahydrocannabinol (THC) is predominantly hepatic catalyzed by microsomal hydroxylation and oxidation leading to delta 9-tetrahydrocannabidiol.

PMID:33740842 | DOI:10.1111/bcpt.13581

#CBD #Hemp https://pubmed.ncbi.nlm.nih.gov/33740842/?utm_source=Firefox&utm_medium=rss&utm_campaign=None&utm_content=1jYCQzi_o_qLYr-oQfnMhShgOXkvGma3vcnBGJtrBhuJMOvEVJ&fc=None&ff=20210320152558&v=2.14.3 March 19, 2021 10:00 am