Bcl-2 as a Double-edged Sword for the Treatment of Multiple Sclerosis: A Systematic Review
CONCLUSION: While modulating Bcl-2 pathways can be effective in MS, future research should aim to provide greater clarification and to design precision-based drugs capable of...
Structural characterization and in vitro evaluation of the hypolipidemic activity of the HSP-Ia, a bioactive polysaccharide derived from hemp (Cannabis sativa
A novel polysaccharide, HSP-Ia, with a molecular weight of 973.6 kDa, was isolated from hemp (Cannabis sativa L.) seed residues using sequential aqueous extraction, ethanol-induced...
Metabolic effects and pharmacokinetics of oral cannabidiol (CBD) in Connemara ponies following 21 days of treatment
CONCLUSION: CBD did not improve metabolic parameters but was associated with an increased insulin response during the OST, suggesting modulation of insulin dynamics of unclear...
Comparative Disruption Behavior of Essential Oil and Fixed Oil Dietary Supplement Softgels Under Biorelevant Conditions
Softgel capsules are widely used in dietary supplements to deliver lipophilic ingredients, including essential and fixed oils. This study evaluated the disruption behavior of 104...
Selective opioid-sparing effects of cannabidiol on opioid analgesia in rats
Cannabidiol, a major non-psychoactive constituent of cannabis, has generated interest as a novel therapeutic for managing several pathological conditions including chronic pain and opioid use...
Cannabinoids for Alzheimer’s disease: A promising trial, although not yet ready for the prescription pad
Cury et al. present the first randomized placebo-controlled trial of a low-dose balanced tetrahydrocannabinol-cannabidiol extract targeting cognition in Alzheimer's disease (AD). The study marks a...
Cannabidiol enhances tamoxifen efficacy via CREB-mediated suppression of ERalpha signaling in ER-positive breast cancer cells
CONCLUSIONS: Our findings demonstrate that CBD restores TAM sensitivity through CREB-mediated downregulation of ERα signaling in ER-positive breast cancer. This study suggests the potential application...
Solubility-improved and antitumor activity of (-)-cannabidiol conjugates
CONCLUSIONS: Collectively, our results highlight the critical role of conjugate structure in modulating physicochemical and biological properties of CBD and underscore the potential of these...
Safety of cannabidiol isolate from Cannabis sativa L. as a novel food pursuant to Regulation (EU) 2015/2283
Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on...
A Phase-2 Open-Label Trial of Cannabidiol to Treat Core and Associated Symptoms of Autism in Children and Adolescents Without Intellectual Disability
CONCLUSIONS: In this preliminary study, CBD was well tolerated; AEs were mild-moderate. Mean SRS2-T and subscores decreased significantly with large effect sizes, shifting from the...
Emerging preclinical evidence supports a potential role for cannabidiol in the management of sickle cell disease
Sickle cell disease (SCD) imposes a substantial global health burden, with acute and chronic pain representing a major component of morbidity. Standard pain management, largely...
COMPOSITION FOR PREVENTING OR AMELIORATING MUSCLE DISEASES, COMPRISING HEMP SEED EXTRACT
The present invention relates to the use of a hemp seed extract for preventing or ameliorating muscle diseases by promoting myoblast differentiation or muscle regeneration...
AEROSOL-GENERATING ARTICLE COMPRISING A NOVEL SUBSTRATE
An aerosol-generating article (1)(2) comprises a rod of an aerosol-generating substrate (12)(212), the aerosol-generating substrate (12)(212) comprising at least 60 percent by weight of hemp...
CANNABIDIOL COMPOSITIONS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE AND NEUROLOGICAL DISORDERS
The present disclosure provides cannabinoid drug substances, pharmaceutical compositions and methods of treating neurological or neurodegenerative disorders in a human patient...
The Endocannabinoid System in Neuropsychiatric Disorders: Mechanisms, Dysregulation and Therapeutic Potential
The endocannabinoid system (ECS) is a fundamental regulator of brain and body homeostasis, integrating neural, immune, and stress-related signaling pathways. Dysregulation of ECS components, including...
Antitumor Activity of Cannabinoids and Their Interaction with Chemotherapy: A Systematic Review and Meta-Analysis of Preclinical Evidence
Background: Cannabinoids are studied as anticancer agents, but their effects vary across tumors, compounds, and experimental settings, underscoring the need to define consistent patterns. Our...
Natural Products in Epilepsy Treatment: From Traditional Medicine Towards Computational Drug Discovery
Epilepsy affects approximately 50 million people worldwide, with nearly one-third of patients experiencing drug-resistant seizures despite available antiepileptic drugs (AEDs). Natural products remain an important...
Cannabidiolic acid causes a defect in tail retraction of migrating MDA-MB-231 cells: Possible involvements of Rho-associated protein kinases (ROCKs)
We previously reported that cannabidiolic acid (CBDA), a major cannabinoid constituent of the fiber-type cannabis plant, abrogates the migration of highly aggressive human breast cancer...