Cannabigerol Enhances Muscle Strength and Performance in Dexamethasone-Treated Mice
Sarcopenia is a major clinical condition associated with aging and is characterized by progressive loss of skeletal muscle mass and function. Resistance training is an...
Antinociceptive interaction of delta(9)-tetrahydrocannabinol and cannabidiol in a humanized mouse model of sickle cell disease
Sickle cell disease (SCD) is characterized by recurrent, debilitating pain. Opioid analgesics are routinely used in its management, but limited efficacy and pervasive side effects...
The Use of Cannabidiol in Cutaneous Wound Healing: A Systematic Review
Cutaneous wounds represent a significant health problem due to their high prevalence, functional impact, and effects on quality of life. Cannabidiol (CBD), a non-psychoactive compound...
Phytocannabinoid-drug interactions: pharmacokinetic and pharmacodynamic mechanisms, clinical relevance and toxicological considerations
The therapeutic use of phytocannabinoids has expanded considerably over the past decade because of their potential application across a wide range of clinical conditions. However...
Cannabis Co-Use and Endocannabinoid System Modulation in Tobacco Use Disorder
Tobacco use disorder (TUD) remains a leading cause of preventable mortality, and existing pharmacotherapies yield 12-month abstinence rates below 30%. As cannabis legalization expands, approximately...
Structure and functional properties of Dendrobium officinale polysaccharide-hemp seed protein gels for dysphagia diets as regulated by alkali concentration
Dysphagia is highly prevalent among older adults and increases the risks of malnutrition, dehydration, and aspiration pneumonia, highlighting the need for safe and nutritionally adequate...
Impact of Migraine and Its Management in 5 Gulf Countries: Results of a Social Media Platforms Listening Study
CONCLUSIONS: The study finds that analysis of migraine discourse across the 5 Gulf countries reveals active engagement by patients and HCPs in migraine-related discussions on...
Cannabis for sleep in older adults: use has outpaced the science
Cannabis use among older adults, defined here as those over 50 years of age, has increased rapidly, and sleep disturbance is among the most common...
Alternating hemiplegia of childhood – a systematic review
CONCLUSIONS: Alternating hemiplegia of childhood is a complex multisystem disorder requiring early diagnosis, continuous monitoring, and multidisciplinary care. Disease-modifying treatments remain urgently needed...
Hempseeds as sustainable plant-based source of bioactive peptides with biofunctional properties
The contribution of oxidative stress and inflammation to various diseases coupled with the many side-effects of pharmaceuticals has underscored the need for strategies that integrate...
IMPROVED CANNABIDIOL FORMULATIONS
The present invention relates to compositions comprising cannabidiol having improved pharmacokinetics, and therapeutic uses thereof...
CANNABINOID-BASED FORMULATION
The invention relates to cannabinoid-based formulations, and particularly, although not exclusively, to methods for preparing cannabinoid-based formulations, and to the formulations per se, and their...
Cannabidiol/cannabigerol exposure and neuropathy-related outcomes after neurotoxic chemotherapy: a real-world cohort study
CONCLUSIONS: Post-chemotherapy CBD/CBG exposure was associated with lower observed hazard of neuropathy-related diagnosis-code outcomes, whereas pre-chemotherapy exposure was not significant. These exploratory findings require cautious...
The Pharmacokinetic and Pharmacodynamic Drug-drug Interaction Potential of Cannabidiol
Although Cannabidiol (CBD) has recently been approved for use in some neurological diseases, the pharmacology of CBD is not fully understood. Experimental reports suggest CBD...
The levels of Twist1 homodimerization over heterodimerization with E proteins control osteogenic differentiation and calcification in the adult porcine aortic
Millions of people are affected by calcific aortic valve disease (CAVD) every year globally, and the only effective therapy is limited to surgical or transcatheter...
Revisión sistemática sobre las estrategias terapéuticas en la dispepsia funcional: abordajes farmacológicos y no farmacológicos según el subtipo clínico
Functional dyspepsia is a disorder of gut-brain interaction that significantly affects quality of life and has a limited therapeutic response. This systematic review, conducted according...