Bridging evidence gaps in dravet syndrome: real-world safety insights from under-reported antiseizure therapies
INTRODUCTION: Dravet syndrome is an early-onset developmental and epileptic encephalopathy in which management must extend beyond seizure control to include the monitoring and treatment of...
Preliminary Prospective Study of Pharmaceutical-Grade Cannabidiol for Seizure Frequency, Anxiety, and Comorbid Symptoms in Pediatric Epilepsy: Associations
Anxiety commonly co-occurs with childhood epilepsy, yet treatments targeting both are limited. Epidiolex (cannabidiol, CBD) is an FDA-approved treatment for seizures associated with rare pediatric...
Effect of O-acetylation on ketene and carbonyl yields from conventional and emerging cannabinoids
The pulmonary toxicant, ketene, has been observed from electronic (e-) cigarette vaping and dabbing (flash vaporisation) of acetylated compounds such as Vitamin E Acetate (VEA)...
Mechanistic Pathways Linking Cannabidiol, Hemp Seed Oil and Black Sesame Oil in Hyperarousal Insomnia: A Narrative Review
Insomnia is increasingly recognized as a manifestation of multisystem dysregulation characterized by sustained physiological hyperarousal. This review situates insomnia within a framework of reciprocal disturbances...
Spectrolipidomics of glial cell lines: A deuterated probe for semiquantitative monitoring of cannabidiol-induced cholesterol modulation
Understanding lipid metabolism in peripheral glial cells is crucial for elucidating the molecular mechanisms underlying neurodegeneration, cancerogenesis and therapy resistance. Here, we introduce a spectrolipidomic...
Retrospective 280 relief?
What’s the precedent for retrospective tax relief like that proposed today for 280E by the federal government? (Finding standing to challenge such relief would be hard.)...
An Accurate Method Based on Ultra-High-Performance Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry for the Quantification of Five
Caenorhabditis elegans is an alternative model organism for toxicology research that aligns with the 3Rs principle (Replace, Reduce, Refine) and new approaches to modernize toxicity...
Recreational Drug Use at a Music Festival: A Dual Approach Using Hair Biomarkers Analysis and Participant Self-Reported Drug Use
The growing prevalence of substance use and its associated health consequences highlights the need for reliable approaches to assess consumption patterns and validate self-reported data...
Safety of carbon dioxide extract from Cannabis sativa L. as a novel food pursuant to Regulation (EU) 2015/2283
Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on...
Oral Cannabidiol in the Treatment of Myofascial Pain Disorder of the Temporomandibular Region: A Placebo-Controlled Randomized Clinical Trial
CONCLUSION: Both CBD and hemp seed oil did appear to improve jaw function over time, but neither treatment improved pain...
Does oral cannabidiol oil in adjunct to pain medications help reduce pain and improve locomotion in dogs with osteoarthritis?
CONCLUSION: CBD oil oral supplementation displayed a significant effect of extra pain relief on top of conventional treatment of canine OA in the clinical trials...
Potassium Channelopathies and Precision Medicine Approaches in Epilepsy: A Systematic Review of Personalized Treatment Strategies
CONCLUSION: These studies collectively offer valuable insights into precision medicines for genetic epilepsy caused by pathogenic potassium variants. This review is essential because it informs...
Muscular Dystrophy Muscle Preservation: A Comparative Systematic Review of Exercise and Cannabidiol (CBD) Interventions
Muscular dystrophy comprises a heterogeneous group of inherited neuromuscular disorders characterized by progressive muscle degeneration, weakness, and functional decline. In the absence of curative pharmacologic...
Cannabidiol-Loaded Smart Hydrogels for Advanced Wound Healing: Drug Delivery Innovations and Therapeutic Perspectives
Chronic wounds are a leading healthcare burden worldwide, fueled by intricate pathophysiology and the inadequacy of standard therapies. The present review critically discusses the novel...
Cannabidiol at the crossroads: panacea, placebo, or problem?
Cannabidiol (CBD) is widely perceived as a safe and effective treatment for a growing list of health indications and use for general wellness. Evidence for...
In silico receptor binding and ex vivo nasal epithelial membrane permeation studies of selected phytocannabinoids
CONCLUSION: Through affinity for the CB2 receptor, the identified compounds have shown potential in migraine treatment. There is also potential for nose-to-brain delivery...
Real-world effectiveness of highly purified cannabidiol in epilepsy associated with 15q11.2-q13.1 duplication and deletion syndromes: A multicenter study
This multicenter retrospective study evaluated the effectiveness and safety of highly purified cannabidiol (CBD) in 22 patients with 15q11.2-q13.1 duplication or deletion syndromes (15q-DDS), including...
Peptidomics reveals enhanced bioactivities of hempseed cake induced by solid-state fermentation
Novel peptides generated from solid-state fermented hempseed cake were characterized by peptidomics and validated for bioactivity. Fermentation with Aspergillus niger, Bacillus subtilis, and Lactobacillus rhamnosus...