Plasma-based treatments regulate seed germination in Cannabis sativa via oxidative status modulation and transcriptional changes
Cannabis sativa (hemp) is an industrial crop with expanding applications in the agrifood, textile, and pharmaceutical sectors. Despite its economic potential, seed germination and quality...
Optimisation and validation of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for cannabis and its metabolites in urine
The two most abundant phytocannabinoids are Δ⁹-tetrahydrocannabinol (THC) and cannabidiol (CBD). Their major metabolites include 7-hydroxy-cannabidiol (CBD-OH), 7-carboxy-cannabidiol (CBD-COOH), 11-hydroxy-Δ⁹-tetrahydrocannabinol (THC-OH) and 11-carboxy-Δ⁹-tetrahydrocannabinol (THC-COOH). As...
Anti-Neuroinflammatory Cannabinoid Acids as a New Therapeutic Approach for Multiple Sclerosis
Neuroinflammation is a hallmark of multiple sclerosis (MS). MS is marked by glial cell activation, autoreactive T cells, and the release of pro-inflammatory cytokines and...
Natural Hydrophobic Deep Eutectic Solvent-Based Enhanced Extraction of Bioactive Compounds from Cannabis sativa L. Leaf for Pharmaceutical Applications
Cannabis sativa L. leaves (CSL) are a rich in bioactive compounds and known for their medicinal and recreational uses. In this study, a natural hydrophobic...
Transcriptome assemblies for two drug-type cannabis chemotypes by long-read RNA sequencing
Cannabis sativa has undergone over 10,000 years of domestication, resulting in extensive genetic and phenotypic diversity among cultivated chemotypes. Increased medical and recreational use of...
Neurological effects of cannabidiol in olanzapine/high-fat diet co-treated adult male Wistar rats
ABSTARCTThe present study investigates the neuroprotective effects of Cannabidiol (CBD) in olanzapine/high-fat diet (HFD) treated adult male Wistar rats. Animals weighing 160-180 g were divided...
Inhibition of extracellular vesicle secretion by cannabidiol: A promising approach for oral squamous cell carcinoma therapy
Cannabidiol (CBD), a bioactive phytochemical derived from Cannabis sativa, exhibits anti-inflammatory, antioxidant, and emerging antitumor properties. Oral squamous cell carcinoma (OSCC), the most common oral...
Cannabidiol and diabetic heart disease: Mechanistic evidence and translational challenges
Diabetic heart disease (DHD) is a major contributor to global cardiovascular morbidity, driven by a complex interplay of metabolic, inflammatory, oxidative, and fibrotic mechanisms. These...
Cannabidiol Use in Inflammatory Bowel Disease: Insights From a Gastroenterology Outpatient Population
Cannabidiol (CBD) is increasingly used for symptom relief in chronic conditions, yet its role in inflammatory bowel disease (IBD) remains underexplored. We surveyed 229 IBD...
Cannabidiol dose modulates behavioral response to acute and repeated administration of delta9-Tetrahydrocannabinol by strain and sex
Cannabis contains many bioactive compounds, including Δ9-Tetrahydrocannabinol (THC) and cannabidiol (CBD), which influence behavior through complex pharmacological interactions with endogenous targets. This study examines whether...
Cannabidiol synergizes with methotrexate to attenuate rheumatoid arthritis via STAT3/NF-kappaB signalling-mediated M1 macrophage polarization
CONCLUSION: The CBD-MTX combination exerts superior antiarthritic effects by inhibiting STAT3/NF-κB-mediated M1 macrophage polarization and protecting against MTX-induced reproductive toxicity. This study provides a preclinical...
Effect of cannabinol, tetrahydrocannabivarin and cannabidiol on voluntary alcohol consumption
CONCLUSIONS: We conclude that CBN and THCV may have potential in treating AUD...
Cannabidiol for psychotic disorders: A meta-analysis of randomized controlled trials
CONCLUSIONS: Despite the limited number of outcomes assessed at the current state of the evidence, CBD did not show a clear benefit for psychosis symptoms...
Increased reluctant vesicles underlie synaptic depression by GPR55 in axon terminals of rat cerebellar Purkinje cells
Control of synaptic transmission efficacy by neuronal activity and neuromodulators is pivotal for brain function. Synaptic suppression by cannabinoids activating CB1 receptors has been extensively...
Cognitive performance and subjective effects the morning after last use of smoked cannabis by adults who use cannabis frequently: An observational study
CONCLUSIONS: There was no measurable next-day cognitive differences between groups, despite some subjective intoxication in the cannabis group. Nonetheless, higher THC potency and elevated cannabinoid...
Treatment-refractory Addictions: Clinical Characterization and an Operational Model for Integrated Management
The current mental health system faces an important yet not well-understood problem, which involves addictions that do not respond to treatment. The cases present with...
Cannabidiol as a Modulator of the Gut-Liver Axis: Clinical and Pharmacological Insights into Hepatic and Metabolic Disorder Therapies
A non-intoxicating substance produced from Cannabis sativa, cannabidiol (CBD) has shown promise as a treatment for metabolic and hepatic diseases, primarily due to its capacity...