PubMed: Development of a gold nanoparticle-based lateral-flow strip for the detection of cannabidiol in functional beverages

PubMed: Development of a gold nanoparticle-based lateral-flow strip for the detection of cannabidiol in functional beverages

Analyst. 2023 Mar 14. doi: 10.1039/d3an00084b. Online ahead of print.

ABSTRACT

Cannabidiol (CBD), the most predominant cannabinoid, may cause addiction and liver damage. In this study, we synthesized a CBD hapten containing the carboxyl group of the spacer arm by derivatizing CBD. A highly specific and sensitive monoclonal antibody (mAb) was prepared with a half-maximal inhibitory concentration of 2.03 ng mL^-1 and a limit of detection of 0.32 ng mL^-1. MAb was highly specific for CBD. We developed an immunochromatographic assay (ICA) for the detection of CBD in functional beverages with a visible limit of detection of 100 ng mL^-1 and a cut-off of 1000 ng mL^-1. Compared with HPLC, ICA is more efficient and accurate and can be used for the rapid on-site detection of CBD in samples.

PMID:36916524 | DOI:10.1039/d3an00084b

https://pubmed.ncbi.nlm.nih.gov/36916524/?utm_source=Chrome&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1NqsX9BbHlDygQ8TcgAlJilHgPpiuKQtyIr–a3-xbLzPoB9xM&fc=20220928170152&ff=20230314190741&v=2.17.9.post6+86293ac March 14, 2023 10:00 am

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