StatPearls

StatPearls

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StatPearls

Book. 2020 01

Authors:

Abstract
Delta-9-tetrahydrocannabinol (THC) is the primary psychoactive cannabinoid extracted from the cannabis(marijuana) plant. It was historically used recreationally due to its psychoactive effects, but recently there has been significant interest in exploring its medical utility.

PMID: 33085321

#CBD #Hemp https://www.ncbi.nlm.nih.gov/pubmed/33085321?dopt=Abstract

Cannabidiol interactions with voltage-gated sodium channels.

Cannabidiol interactions with voltage-gated sodium channels.

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Cannabidiol interactions with voltage-gated sodium channels.

Elife. 2020 Oct 22;9:

Authors: Sait LG, Sula A, Ghovanloo MR, Hollingworth D, Ruben PC, Wallace BA

Abstract
Voltage-gated sodium channels are targets for a range of pharmaceutical drugs developed for treatment of neurological diseases. Cannabidiol (CBD), the non-psychoactive compound isolated from cannabis plants, was recently approved for treatment of two types of epilepsy associated with sodium channel mutations. This study used high resolution X-ray crystallography to demonstrate the detailed nature of the interactions between CBD and the NavMs voltage-gated sodium channel, and electrophysiology to show the functional effects of binding CBD to these channels. CBD binds at a novel site at the interface of the fenestrations and the central hydrophobic cavity of the channel. Binding at this site blocks the transmembrane-spanning sodium ion translocation pathway, providing a molecular mechanism for channel inhibition. Modelling studies suggest why the closely-related psychoactive compound tetrahydrocannabinol may not have the same effects on these channels. Finally, comparisons are made with the TRPV2 channel, also recently proposed as a target site for CBD. In summary, this study provides novel insight into a possible mechanism for CBD interactions with sodium channels.

PMID: 33089780 [PubMed – as supplied by publisher]

#CBD #Hemp https://www.ncbi.nlm.nih.gov/pubmed/33089780?dopt=Abstract

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CBD Treatments in Gainesville, Florida

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Everything You Need to Know Before Trying cbdMD Products, According to an Expert

Everything You Need to Know Before Trying cbdMD Products, According to an Expert Hemp-derived products made with broad-spectrum CBD are free of THC, which means it's essentially impossible for them to cause any intoxicating … #CBD #Hemp https://www.google.com/url?rct=j&sa=t&url=https://www.health.com/mind-body/cbd/cbdmd-cbd-review&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNGfTAYKJyc7nL3zE4-li0QnAUZiGQ October 23, 2020 12:56 am

Flip flops Sports & Outdoor Sandalswomen Home Indoor Hemp Slipper Casual Soft Floor NonSlip …

Flip flops Sports & Outdoor Sandalswomen Home Indoor Hemp Slipper Casual Soft Floor NonSlip … CO,Flip flops Sports & Outdoor Sandalswomen Home Indoor Hemp Slipper Casual Soft Floor NonSlip Slippers Family ShoeB_12 sandals,KAB,KAB-B … #CBD #Hemp https://www.google.com/url?rct=j&sa=t&url=https://www.elcamino.edu/174510/pdk-indoor-hemp-11124503.html&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNFD9g4Xpct5LS8x5_dok4fDYmQ8XA October 23, 2020 12:28 am

Vicente Sederberg LLP Hemp Update: October 2020

Vicente Sederberg LLP Hemp Update: October 2020 Federal Updates. Great News for Hemp Farmers! Congress Extends 2014 Farm Bill. After months of lobbying and requests from the industry to extend … #CBD #Hemp https://www.google.com/url?rct=j&sa=t&url=https://vicentesederberg.com/updates/vicente-sederberg-hemp-update-october-2020/&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNEAbxwVfcFNF9lQe7WjRqChhQ_naw October 22, 2020 11:29 pm

The Best CBD Salves and Balms for Athletes

The Best CBD Salves and Balms for Athletes Cannabidiol (CBD), the cannabis compound that's been touted for its healing effects without getting you “high,” has gotten attention for alleviating … #CBD #Hemp https://www.google.com/url?rct=j&sa=t&url=https://www.healthline.com/health/best-cbd-salve-for-athletes&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNGel95HeuVbUUj1OxvO6t3XPBY33g October 22, 2020 10:52 pm

Cannabis Co. Wants Grand Jury Transcripts In Dumping Case

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Hemp approved for harvest in south-central Kansas

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Remedio Wellness Announces the Next Generation of Hemp-Based Treatments

Remedio Wellness Announces the Next Generation of Hemp-Based Treatments CBD has been known to reduce pain, inflammation, anxiety, and discomfort related to a variety of health conditions. In fact, a 2019 Gallup poll found … #CBD #Hemp https://www.google.com/url?rct=j&sa=t&url=https://www.cbdtoday.com/remedio-wellness-announces-the-next-generation-of-hemp-based-treatments/&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNH0-DmE68IOv-26RikBKFCurHHzwQ October 22, 2020 10:30 pm

What are the Health Benefits of CBD Oil?

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Industrial hemp plant opens doors

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City-Exclusive Pot Transport Deal Is OK, Calif. Panel Says

City-Exclusive Pot Transport Deal Is OK, Calif. Panel Says A California appeals court has ruled that an exclusive deal the city of Baldwin Park cut with Rukli Inc. to transport cannabis in the city is valid, saying the deal did not violate the state’s marijuana laws because the legislature did not intend to by regulate anti-competitive behavior by municipalities. #CBD #Hemp https://www.law360.com/cannabis/articles/1322116?utm_source=rss&utm_medium=rss&utm_campaign=section October 22, 2020 9:20 pm

PerkinElmer Introduces Fully Automated Workflow for Cannabis and Hemp Pesticide Residue …

PerkinElmer Introduces Fully Automated Workflow for Cannabis and Hemp Pesticide Residue … … chromatography–tandem mass spectrometry (LC–MS/MS) analysis workflow for pesticide residue testing of cannabis and hemp flower samples. #CBD #Hemp https://www.google.com/url?rct=j&sa=t&url=https://www.cannabissciencetech.com/view/perkinelmer-introduces-fully-automated-workflow-for-cannabis-and-hemp-pesticide-residue-testing&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNGEFGmBrE_E521wwOUpdiuwmDxPmg October 22, 2020 9:11 pm

Kefla Launches New CBD Latte & Hot Cocoa Mixes

Kefla Launches New CBD Latte & Hot Cocoa Mixes One serving makes an 8oz drink with 25mg CBD derived from Organic Full Spectrum Hemp Extract and 825mg Organic Reishi Extract 4:1 Can be used … #CBD #Hemp https://www.google.com/url?rct=j&sa=t&url=https://www.nosh.com/food-wire/2020/kefla-launches-new-cbd-latte-hot-cocoa-mixes/&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNFzn2wVpkD73gmIW1fPJdu00io4_Q October 22, 2020 9:11 pm

CBD store opening in downtown Arlington Heights

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Oligarch's Estate Says Ex-Pot Co. CEO Must Arbitrate Fight

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Hemp growers association usa

Hemp growers association usa hemp growers association usa and resides in Graves County KY. The NCIHA is available to provide professional assistance guidance and advice to … #CBD #Hemp https://www.google.com/url?rct=j&sa=t&url=https://emmanuelawollochmd.com/fogging-machine/hemp-growers-association-usa.html&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNHxiGUr504PBXEwDo7-tyeSCUV3Pw October 22, 2020 8:28 pm

Criticality's Korent Select™ CBD Brand Launches Latest Moisture-focused Product

Criticality's Korent Select™ CBD Brand Launches Latest Moisture-focused Product In addition to hemp extract containing CBD, the spray-on product features nourishing ingredients such as olive oil and shea butter, making it ideal for … #CBD #Hemp https://www.google.com/url?rct=j&sa=t&url=https://www.prnewswire.com/news-releases/criticalitys-korent-select-cbd-brand-launches-latest-moisture-focused-product-301158405.html&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNE43LA1nPT99VJw7MEf4LY3iQI0dw October 22, 2020 8:15 pm

USDA approval of state's industrial hemp plan clears way for 2021 growing season

USDA approval of state's industrial hemp plan clears way for 2021 growing season The U.S. Department of Agriculture approved South Dakota's plan for industrial hemp on Friday, Oct. 16, clearing the way for the program to be ready … #CBD #Hemp https://www.google.com/url?rct=j&sa=t&url=https://www.timberlakesouthdakota.com/news/usda-approval-states-industrial-hemp-plan-clears-way-2021-growing-season&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNFAxceAKfaqwqFPQDsp-rCliU6qPQ October 22, 2020 8:15 pm

Evidence for side effects of cannabidiol (CBD) products and their non-conformity on the European food market – response to the European Industrial Hemp Association.

Evidence for side effects of cannabidiol (CBD) products and their non-conformity on the European food market – response to the European Industrial Hemp Association.

Icon for F1000 Research Ltd Icon for PubMed Central

Evidence for side effects of cannabidiol (CBD) products and their non-conformity on the European food market – response to the European Industrial Hemp Association.

F1000Res. 2020;9:1051

Authors: Lachenmeier DW, Walch SG

Abstract
An interesting and valuable discussion has arisen from our recent article (Lachenmeier et al., 2020) and we are pleased to have the opportunity to expand on the various points we made. Equally important, we wish to correct several important misunderstandings that were made by Kruse and Beitzke (2020) on behalf of the European Industrial Hemp Association (EIHA) that possibly contributed to their concerns about the validity of our data, toxicological assessment and conclusions regarding regulatory status of cannabidiol (CBD) products. First and foremost, our study did only assess the risk of psychotropic Δ 9-tetrahydrocannabinol (THC) without inclusion of non-psychotropic Δ 9-tetrahydrocannabinolic acid (THCA). Secondly, as this article will discuss in more detail, there is ample evidence for side effects of CBD products, not only in paediatric patients, but also in adult users of over-the-counter CBD products (including inadvertent “high” effects). Thirdly, the exposure and risk assessment was conducted using up-to-date guidelines according to the European Food Safety Authority (EFSA) and the German Federal Institute for Risk Assessment (BfR). And finally, the current legal situation in the European Union, without approval of any hemp extract-containing product according to the Novel Food regulation, actually allows blanket statements that all such products are illegal on the market, and this indeed would imply a general ban on the use and marketing of such products as food or food ingredients until such an approval has been granted. We hope that this reassures the F1000Research readership regarding the validity of our results and conclusions. We are pleased, though, that the EIHA has acknowledged the fact that there are non-compliant CBD products available, but according to our data these are a substantial fraction of the market.

PMID: 33082934 [PubMed – in process]

#CBD #Hemp https://www.ncbi.nlm.nih.gov/pubmed/33082934?dopt=Abstract

Therapeutic potential and safety considerations for the clinical use of synthetic cannabinoids.

Therapeutic potential and safety considerations for the clinical use of synthetic cannabinoids.

Icon for Elsevier Science

Therapeutic potential and safety considerations for the clinical use of synthetic cannabinoids.

Pharmacol Biochem Behav. 2020 Oct 18;:173059

Authors: Sholler DJ, Huestis MA, Amendolara B, Vandrey R, Cooper ZD

Abstract
The phytocannabinoid Δ9-tetrahydrocannabinol (THC) was isolated and synthesized in the 1960s. Since then, two synthetic cannabinoids (SCBs) targeting the cannabinoid 1 (CB1R) and 2 (CB2R) receptors were approved for medical use based on clinical safety and efficacy data: dronabinol (synthetic THC) and nabilone (synthetic THC analog). To probe the function of the endocannabinoid system further, hundreds of investigational compounds were developed; in particular, agonists with (1) greater CB1/2R affinity relative to THC and (2) full CB1/2R agonist activity. This pharmacological profile may pose greater risks for misuse and adverse effects relative to THC, and these SCBs proliferated in retail markets as legal alternatives to cannabis (e.g., novel psychoactive substances [NPS], “Spice,” “K2”). These SCBs were largely outlawed in the U.S., but blanket policies that placed all SCB chemicals into restrictive control categories impeded research progress into novel mechanisms for SCB therapeutic development. There is a concerted effort to develop new, therapeutically useful SCBs that target novel pharmacological mechanisms. This review highlights the potential therapeutic efficacy and safety considerations for unique SCBs, including CB1R partial and full agonists, peripherally-restricted CB1R agonists, selective CB2R agonists, selective CB1R antagonists/inverse agonists, CB1R allosteric modulators, endocannabinoid-degrading enzyme inhibitors, and cannabidiol. We propose promising directions for SCB research that may optimize therapeutic efficacy and diminish potential for adverse events, for example, peripherally-restricted CB1R antagonists/inverse agonists and biased CB1/2R agonists. Together, these strategies could lead to the discovery of new, therapeutically useful SCBs with reduced negative public health impact.

PMID: 33086126 [PubMed – as supplied by publisher]

#CBD #Hemp https://www.ncbi.nlm.nih.gov/pubmed/33086126?dopt=Abstract

Evidence for side effects of cannabidiol (CBD) products and their non-conformity on the European food market – response to the European Industrial Hemp Association.

Evidence for side effects of cannabidiol (CBD) products and their non-conformity on the European food market – response to the European Industrial Hemp Association.

Icon for F1000 Research Ltd Icon for PubMed Central

Evidence for side effects of cannabidiol (CBD) products and their non-conformity on the European food market – response to the European Industrial Hemp Association.

F1000Res. 2020;9:1051

Authors: Lachenmeier DW, Walch SG

Abstract
An interesting and valuable discussion has arisen from our recent article (Lachenmeier et al., 2020) and we are pleased to have the opportunity to expand on the various points we made. Equally important, we wish to correct several important misunderstandings that were made by Kruse and Beitzke (2020) on behalf of the European Industrial Hemp Association (EIHA) that possibly contributed to their concerns about the validity of our data, toxicological assessment and conclusions regarding regulatory status of cannabidiol (CBD) products. First and foremost, our study did only assess the risk of psychotropic Δ 9-tetrahydrocannabinol (THC) without inclusion of non-psychotropic Δ 9-tetrahydrocannabinolic acid (THCA). Secondly, as this article will discuss in more detail, there is ample evidence for side effects of CBD products, not only in paediatric patients, but also in adult users of over-the-counter CBD products (including inadvertent “high” effects). Thirdly, the exposure and risk assessment was conducted using up-to-date guidelines according to the European Food Safety Authority (EFSA) and the German Federal Institute for Risk Assessment (BfR). And finally, the current legal situation in the European Union, without approval of any hemp extract-containing product according to the Novel Food regulation, actually allows blanket statements that all such products are illegal on the market, and this indeed would imply a general ban on the use and marketing of such products as food or food ingredients until such an approval has been granted. We hope that this reassures the F1000Research readership regarding the validity of our results and conclusions. We are pleased, though, that the EIHA has acknowledged the fact that there are non-compliant CBD products available, but according to our data these are a substantial fraction of the market.

PMID: 33082934 [PubMed – in process]

#Hemp https://www.ncbi.nlm.nih.gov/pubmed/33082934?dopt=Abstract

CBD for LGS: Fewer seizures, but thrombocytopenia risk

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Victoria's Industrial Hemp Taskforce Reports In

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Judge Says Ill. Pot Growers Have To Wait Longer For Licenses

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Unlock the Power of Superfood Hemp This Winter Season to Keep Illnesses at Bay

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After delays, CBD-infused, all-day brunch concept Wake 'N Bacon launching in Chicago Thursday

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Nine Members Of Congress Tell DEA To Revise Proposed Hemp Rule On THC Content

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Can CBD help fight COVID-19? Scientists think so

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CBD Skin Care Products

CBD Skin Care Products Ointments like Anti-Stress CBD Drops from Glo Skin Beauty contain full-spectrum cannabidiol – derived from the leaves and flowers of the hemp plant – … #CBD #Hemp https://www.google.com/url?rct=j&sa=t&url=https://www.citizentribune.com/insiders/cbd-skin-care-products/article_2b1d8d30-148f-11eb-826b-4b3cb50e8482.html&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNEx-hK2tSzLHac9bPaK-H04U8f3eg October 22, 2020 6:00 pm

Do you need THC for CBD to work?

Do you need THC for CBD to work? To those that are outside of the cannabis and hemp industry, the two most well known are THC and CBD. THC, short for Δ-9-tetrahydrocannabinol, … #CBD #Hemp https://www.google.com/url?rct=j&sa=t&url=https://panxchange.com/do-you-need-thc-for-cbd-to-work/&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNFxJDXZKnIt_iJqZf6dtzh08x1xqg October 22, 2020 5:44 pm

Montana High Court Rejects Challenge To Pot Legalization Bid

Montana High Court Rejects Challenge To Pot Legalization Bid The Montana Supreme Court rebuffed a last-minute challenge to the state’s marijuana legalization ballot measure, saying an anti-drug group can’t bring its lawsuit directly to the high court. #CBD #Hemp https://www.law360.com/cannabis/articles/1322022?utm_source=rss&utm_medium=rss&utm_campaign=section October 22, 2020 5:40 pm

USDA Approves Michigan Hemp Plan

USDA Approves Michigan Hemp Plan Michigan's industrial hemp plan will officially go into effect on December 1 after the USDA issued its approval. Full story after the jump. a word from our … #CBD #Hemp https://www.google.com/url?rct=j&sa=t&url=https://www.ganjapreneur.com/usda-approves-michigan-hemp-plan/&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNEvgt69sdgYTsrLe03bz3uk_2OreQ October 22, 2020 4:30 pm

Does hemp hold the potential to be Nevada's next leading crop?

Does hemp hold the potential to be Nevada's next leading crop? Cherry wine hemp, a strain Extension is growing for research, is showing great potential for growth in Nevada. Photo by Lauren McGue, Extension. #CBD #Hemp https://www.google.com/url?rct=j&sa=t&url=https://www.unr.edu/nevada-today/news/2020/hemp-research&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNHyW0xhyx78jujZkZPa2Xxz9qqVeA October 22, 2020 3:11 pm

Cannabidiol Cbd Companies

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Chase says South Dakota approved for Hemp production in 2021

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Global Cannabidiol (CBD) Market Analysis 2020-2026: ENDOCA, CBD American Shaman, Gaia …

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Out of hemp's many promising uses, one of the best could be in construction

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Hemp textile companies

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3 Bottles – Bulk – 25mg CBD Softgel Capsules with Curcumin and CBG

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What Happens if You Take CBD & Drink Alcohol?

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Chattanooga CBD startup and 2020 Spirit of Innovation winner Landrace Bioscience grows its …

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CBD and THC: Do they complement each other like yin and yang?

CBD and THC: Do they complement each other like yin and yang?

CBD and THC: Do they complement each other like yin and yang?

Pharmacotherapy. 2020 Oct 20;:

Authors: Pennypacker SD, Romero-Sandoval EA

Abstract
Increased public access to cannabis calls for a deeper understanding of cannabis’s constituents and how they interact to induce clinical effects. Whereas trans-Δ⁹-tetrahydrocannabinol (THC) is considered the main psychoactive component in cannabis, producing the associated “high” or “euphoria,” various findings demonstrate medical potential for cannabidiol (CBD), from anxiolytic to antiepileptic implications. This has translated into a public optimism and given way to the popular opinion that CBD can provide countless other therapeutic benefits, including the potential to mitigate some of the adverse side effects of THC, such as intoxication, psychomotor impairment, anxiety, and psychotic symptoms. This is particularly relevant for patients seeking to garner therapeutic benefits from cannabis without experiencing the burden of a significant subjective high. This article thus analyzes the scientific evidence available to support or disprove the idea that presence of CBD is beneficial and can exude a protective effect against THC. A thorough review of relevant literature, a basis from which to interpret such evidence through a critical mechanistic discussion, and the implications for patients are presented in this article.

PMID: 33080058 [PubMed – as supplied by publisher]

#CBD #Hemp https://www.ncbi.nlm.nih.gov/pubmed/33080058?dopt=Abstract

CBD use growing for variety of applications

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Level Out With 25% off Premium CBD Products from Cornbread Hemp

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The Effect of Protein Source on the Physicochemical, Nutritional Properties and Microstructure of High-Protein Bars Intended for Physically Active People.

The Effect of Protein Source on the Physicochemical, Nutritional Properties and Microstructure of High-Protein Bars Intended for Physically Active People.

The Effect of Protein Source on the Physicochemical, Nutritional Properties and Microstructure of High-Protein Bars Intended for Physically Active People.

Foods. 2020 Oct 15;9(10):

Authors: Małecki J, Tomasevic I, Djekic I, Sołowiej BG

Abstract
The purpose of this study was to investigate the effect of protein sources (algae, pumpkin, wheat, sunflower, rice, soy, hemp, pea, and whey) on selected physicochemical, nutritional, and structural parameters of high-protein bars. Texture properties, such as hardness, fracturability, cohesiveness, and adhesiveness, have changed depending on the type of protein used. A significant increase, in particular the hardness parameter relating to the control sample (whey protein concentrate-WPC80), was noted for bars containing algae, sunflower, and wheat proteins, with high values of the adhesiveness parameter concurrently. The use of proteins from algae, pea, and wheat resulted in a significant reduction in the water activity of the finished product compared to WPC80. Bars made with the use of wheat, hemp and pumpkin proteins had noticeably higher viscosities than other samples. Color of the tested bars measured by means of Computer Vision System (CVS) was from light cream (soy, pea) to dark green (hemp, pumpkin). Bars prepared of wheat and algae proteins had the highest nutritional value, while the lowest one was recorded in products containing sunflower and hemp proteins. There was a clear differentiation of amino acids (g/100 g) and microstructure in bars depending on the type of protein used. However, a slight similarity can be found between whey and soy proteins (amino acids) and between whey and sunflower proteins (microstructure). Obtained results suggest that selection of the right type of protein for a given application may have a significant impact on the physicochemical features and microstructure of high-protein bars and their nutritional values.

PMID: 33076297 [PubMed]

#Hemp https://www.ncbi.nlm.nih.gov/pubmed/33076297?dopt=Abstract

Tucker Ellis Add Liquor, Cannabis Regulatory Pro In Chicago

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