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The influence of physiotherapy intervention on patients with multiple sclerosis-related spasticity treated with nabiximols (THC:CBD oromucosal spray).

The influence of physiotherapy intervention on patients with multiple sclerosis-related spasticity treated with nabiximols (THC:CBD oromucosal spray).

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The influence of physiotherapy intervention on patients with multiple sclerosis-related spasticity treated with nabiximols (THC:CBD oromucosal spray).

PLoS One. 2019;14(7):e0219670

Authors: Grimaldi AE, De Giglio L, Haggiag S, Bianco A, Cortese A, Crisafulli SG, Monteleone F, Marfia G, Prosperini L, Galgani S, Mirabella M, Centonze D, Pozzilli C, Castelli L

Abstract
BACKGROUND: Nabiximols (THC/CBD Oromucosal Spray, Sativex) is used as an add-on therapy to treat moderate to severe spasticity of Multiple Sclerosis (MS).
OBJECTIVES: To examine the impact of physiotherapy (PT) programs on effectiveness and persistence of nabiximols treatment in people with MS-related spasticity.
METHODS: This is an observational multicenter study with a follow-up period of 12 weeks, conducted in routine care settings in Italy. Patients with moderate to severe MS-related spasticity who started nabiximols were included. Spasticity was evaluated by the patient-rated 0-10 numerical rating scale (NRS). Clinical data were collected at baseline (T0), 4 weeks (T1) and 12 weeks (T2) months after enrollment.
RESULTS: A total of 297 MS patients were selected, 290 completed the 3 months follow-up period. Mean NRS scores were 7.6 ± 1.1 at T0, 5.8 ± 1.4 at T1 and 5.5 ± 1.5 at T2. At T1, 77% of patients reached ≥20% improvement (initial response, IR); 22% reached ≥30% improvement (clinically relevant response, CRR). At T1, patients undergoing PT had a higher probability to reach CRR (Odds Ratio = 2.6 95% CI 1.3-5.6, p = 0.01). Nabiximols was discontinued in 30/290 (10.3%) patients at T1 (early discontinuers) and in 71/290 (24.5%) patients at T2 (late discontinuers). The probability of being late discontinuers was reduced in patients undergoing PT (Hazard Ratio = 0.41; 95% CI 0.23-0.69, p = 0.001).
CONCLUSIONS: Our real-life study confirms nabiximols’ effectiveness in MS-related spasticity and suggests that the association of a PT program may improve overall response and persistence to nabiximols treatment.

PMID: 31361750 [PubMed – indexed for MEDLINE]

The influence of physiotherapy intervention on patients with multiple sclerosis-related spasticity treated with nabiximols (THC:CBD oromucosal spray).

CBD (Cannabidiol) Product Attitudes, Knowledge, and Use Among Young Adults.

CBD (Cannabidiol) Product Attitudes, Knowledge, and Use Among Young Adults.

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CBD (Cannabidiol) Product Attitudes, Knowledge, and Use Among Young Adults.

Subst Use Misuse. 2020 Feb 24;:1-8

Authors: Wheeler M, Merten JW, Gordon BT, Hamadi H

Abstract
Background: Cannabidiol (CBD), a non-psychoactive component of cannabis is marketed as a potential treatment for many conditions and widely available to purchase as a dietary supplement. In 2017, sales of CBD exceeded 820 million dollars despite many unconfirmed health claims, murky legality, and limited product efficacy and safety testing.Purpose/Objectives: This study aims to explore cannabidiol (CBD) knowledge, attitudes, and use among young adults.Methods: The anonymous 36-item survey developed using Qualtrics was distributed via social media from November 2018 to January 2019 with 340 respondents.Results: Of the 340 respondents, 242 reported they had heard of CBD, and 135 reported using CBD products. CBD users were primarily white, female, without children, made less than $25,000 per year, and unmarried. Most commonly used CBD products were edibles (56.30%), tinctures (54.07%), and vape (38.52%). Top reasons for use included stress relief (65.39%), relaxation (54.81%), and sleep improvement (42.22%). Many respondents reported using guesswork to determine dosage, and over half of respondents reported at least one unanticipated side effect.Conclusions/Importance: This study revealed that many users are not responsibly using CBD products, many believe CBD products provide health benefits that are not yet scientifically proven, and they are not knowledgeable about legal and regulatory issues. Until CBD use is more thoroughly researched and has more comprehensive regulation, public health professionals should address alternative stress and anxiety treatment methods.

PMID: 32093530 [PubMed – as supplied by publisher]

CBD (Cannabidiol) Product Attitudes, Knowledge, and Use Among Young Adults.

Effects of topical treatment of cannabidiol extract in a unique manuka factor 5 manuka honey carrier on second intention wound healing on equine distal limb wounds: a preliminary study.

Effects of topical treatment of cannabidiol extract in a unique manuka factor 5 manuka honey carrier on second intention wound healing on equine distal limb wounds: a preliminary study.

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Effects of topical treatment of cannabidiol extract in a unique manuka factor 5 manuka honey carrier on second intention wound healing on equine distal limb wounds: a preliminary study.

Aust Vet J. 2020 Feb 24;:

Authors: McIver VC, Tsang AS, Symonds NE, Perkins NR, Uquillas E, Dart CM, Jeffcott LB, Dart AJ

Abstract
OBJECTIVE: Evaluate the effect of topical 1% cannabidiol on second intention wound healing in distal limb wounds of horses.
DESIGN: Experimental.
ANIMALS: Six Standardbred horses.
METHODS: A total of five 2.5 cm × 2.5 cm full thickness skin wounds were created on the dorsomedial aspect of the metacarpi of 6 horses. Wounds were contaminated with faeces on the day of wound creation. Each wound was then assigned to a treatment group; compounded 1% cannabidiol in unique manuka factor (UMF) 5 manuka honey, UMF 5 manuka honey, UMF 20 manuka honey or saline. Each treatment was applied topically daily for a total of 42 days. Legs were bandaged and bandages were changed, daily, for 13 days postoperatively. Digital photographs of each wound were taken on day 1 then weekly for 6 weeks. Wound size, daily healing rate and total time to healing were recorded and compared statistically.
RESULTS: Irrespective of the treatment, wounds did not retract as expected in the first 7 days after wound creation. There was no difference in wound area, daily healing rate, days to complete healing between treatment groups.
CONCLUSIONS: This preliminary study failed to demonstrate any difference in wound healing variables between treatment groups in this model of second intention wound healing. This was unexpected due to the established effects of UMF 20 manuka honey on wound healing using the same model. This may be due to systemic effects of cannabidiol and study design. Further research into the use of cannabidiol in equine wounds is warranted.

PMID: 32096215 [PubMed – as supplied by publisher]

Effects of topical treatment of cannabidiol extract in a unique manuka factor 5 manuka honey carrier on second intention wound healing on equine distal limb wounds: a preliminary study.

Epilepsy and cannabidiol: a guide to treatment.

Epilepsy and cannabidiol: a guide to treatment.

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Epilepsy and cannabidiol: a guide to treatment.

Epileptic Disord. 2020 Feb 01;22(1):1-14

Authors: Arzimanoglou A, Brandl U, Cross JH, Gil-Nagel A, Lagae L, Landmark CJ, Specchio N, Nabbout R, Thiele EA, Gubbay O

Abstract
The growing interest in cannabidiol (CBD), specifically a pure form of CBD, as a treatment for epilepsy, among other conditions, is reflected in recent changes in legislation in some countries. Although there has been much speculation about the therapeutic value of cannabis-based products as an anti-seizure treatment for some time, it is only within the last two years that Class I evidence has been available for a pure form of CBD, based on placebo-controlled RCTs for patients with Lennox-Gastaut syndrome and Dravet syndrome. However, just as we are beginning to understand the significance of CBD as a treatment for epilepsy, in recent years, a broad spectrum of products advertised to contain CBD has emerged on the market. The effects of these products are fundamentally dependent on the purity, preparation, and concentration of CBD and other components, and consensus and standardisation are severely lacking regarding their preparation, composition, usage and effectiveness. This review aims to provide information to neurologists and epileptologists on the therapeutic value of CBD products, principally a purified form, in routine practice for patients with intractable epilepsy.

PMID: 32096470 [PubMed – in process]

Epilepsy and cannabidiol: a guide to treatment.

Report: Milwaukee's 'Century City' Isn't The Best Spot For A Hemp Farm

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Veterans Vitality CBD Oil – Eliminates All Pain, Reduces Stress & Fatigue!

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3 Women In The CBD Industry Share Their Tips And Product Recommendations for Sleep

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[email protected]: Deadly crash in Hartford; Vaccination bill update; Industrial hemp measure moves to SD …

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Neighbors of Baltimore County hemp farm bring odor complaints to legislature, as industry pushes …

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good hemp® Fizz – 12oz, 35 Calorie Carbonated Energy Drink Infused with Hemp Seed Oil and …

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Good Hemp Registers as a Hemp Processor and Seeks Out Contract Farming For 2020 Harvest

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ReThink CBD Enters The Mass Wellness Beauty Industry and Supermarket Channels

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Cannabis and the exocannabinoid and endocannabinoid systems. Their use and controversies.

Cannabis and the exocannabinoid and endocannabinoid systems. Their use and controversies.

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Cannabis and the exocannabinoid and endocannabinoid systems. Their use and controversies.

Gac Med Mex. 2019;155(5):471-474

Authors: Millán-Guerrero RO, Isais-Millán S

Abstract
Cannabis (marijuana) is one of the most consumed psychoactive substances in the world. The term marijuana is of Mexican origin. The primary cannabinoids that have been studied to date include cannabidiol and delta-9-tetrahydrocannabinol, which is responsible for most cannabis physical and psychotropic effects. Recently, the endocannabinoid system was discovered, which is made up of receptors, ligands and enzymes that are widely expressed in the brain and its periphery, where they act to maintain balance in several homeostatic processes. Exogenous cannabinoids or naturally-occurring phytocannabinoids interact with the endocannabinoid system. Marijuana must be processed in a laboratory to extract tetrahydrocannabinol and leave cannabidiol, which is the product that can be marketed. Some studies suggest cannabidiol has great potential for therapeutic use as an agent with antiepileptic, analgesic, anxiolytic, antipsychotic, anti-inflammatory and neuroprotective properties; however, the findings on cannabinoids efficacy and cannabis-based medications tolerability-safety for some conditions are inconsistent. More scientific evidence is required in order to generate recommendations on the use of medicinal cannabis.

PMID: 32091020 [PubMed – in process]

Cannabis and the exocannabinoid and endocannabinoid systems. Their use and controversies.

Anti-inflammatory Potential of Terpenes Present in Cannabis sativa L.

Anti-inflammatory Potential of Terpenes Present in Cannabis sativa L.

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Anti-inflammatory Potential of Terpenes Present in Cannabis sativa L.

ACS Chem Neurosci. 2020 Feb 24;:

Authors: Downer EJ

Abstract
Cannabis sativa L. (C. sativa) contains an array of plant-derived (phyto) cannabinoids and terpenes that are predominantly located in the trichome cavity of the plant. Terpenes, aromatic organic hydrocarbons characterized for their role in plant protection/pollination, are gaining attention for their potential as novel therapeutics in many areas of biomedicine. This Viewpoint will explore the exciting recent evidence that terpenes have anti-inflammatory/antioxidant propensity by targeting inflammatory signaling mechanisms relevant to human disease. Given their anti-inflammatory properties, terpenes may contribute to the effects of current cannabinoid-based therapies.

PMID: 32091871 [PubMed – as supplied by publisher]

Anti-inflammatory Potential of Terpenes Present in Cannabis sativa L.

Social media surveillance for perceived therapeutic effects of cannabidiol (CBD) products.

Social media surveillance for perceived therapeutic effects of cannabidiol (CBD) products.

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Social media surveillance for perceived therapeutic effects of cannabidiol (CBD) products.

Int J Drug Policy. 2020 Feb 21;77:102688

Authors: Tran T, Kavuluru R

Abstract
BACKGROUND: CBD products have risen in popularity given CBD’s therapeutic potential and lack of legal oversight, despite lacking conclusive scientific evidence for widespread over-the-counter usage for many of its perceived benefits. While medical evidence is being generated, social media surveillance offers a fast and inexpensive alternative to traditional surveys in ascertaining perceived therapeutic purposes and modes of consumption for CBD products.
METHODS: We collected all comments from the CBD subreddit posted between January 1 and April 30, 2019 as well as comments submitted to the FDA regarding regulation of cannabis-derived products and analyzed them using a rule-based language processing method. A relative ranking of popular therapeutic uses and product groups for CBD is obtained based on frequency of pattern matches including precise queries that entail identifying mentions of the condition, a CBD product, and some “trigger” phrase indicating therapeutic use. We validated the social media-based findings using a similar analysis on comments to the U.S. Food and Drug Administration’s (FDA) 2019 request-for-comments on cannabis-derived products.
RESULTS: CBD is mostly discussed as a remedy for anxiety disorders and pain and this is consistent across both comment sources. Of comments posted to the CBD subreddit during the monitored time span, 6.19% mentioned anxiety at least once with at least 6.02% of these comments specifically mentioning CBD as a treatment for anxiety (i.e., 0.37% of total comments). The most popular CBD product group is oil and tinctures.
CONCLUSION: Social media surveillance of CBD usage has the potential to surface new therapeutic use-cases as they are posted. Contemporary social media data indicate, for example, that stress and nausea are frequently mentioned as therapeutic use cases for CBD without corresponding evidence, that affirms or denies, in the research literature. However, the abundance of anecdotal claims warrants serious scientific exploration moving forward. Meanwhile, as FDA ponders regulation, our effort demonstrates that social data offers a convenient affordance to surveil for CBD usage patterns in a way that is fast and inexpensive and can inform conventional electronic surveys.

PMID: 32092666 [PubMed – as supplied by publisher]

Social media surveillance for perceived therapeutic effects of cannabidiol (CBD) products.

Social media surveillance for perceived therapeutic effects of cannabidiol (CBD) products.

Social media surveillance for perceived therapeutic effects of cannabidiol (CBD) products.

Related Articles

Social media surveillance for perceived therapeutic effects of cannabidiol (CBD) products.

Int J Drug Policy. 2020 Feb 21;77:102688

Authors: Tran T, Kavuluru R

Abstract
BACKGROUND: CBD products have risen in popularity given CBD’s therapeutic potential and lack of legal oversight, despite lacking conclusive scientific evidence for widespread over-the-counter usage for many of its perceived benefits. While medical evidence is being generated, social media surveillance offers a fast and inexpensive alternative to traditional surveys in ascertaining perceived therapeutic purposes and modes of consumption for CBD products.
METHODS: We collected all comments from the CBD subreddit posted between January 1 and April 30, 2019 as well as comments submitted to the FDA regarding regulation of cannabis-derived products and analyzed them using a rule-based language processing method. A relative ranking of popular therapeutic uses and product groups for CBD is obtained based on frequency of pattern matches including precise queries that entail identifying mentions of the condition, a CBD product, and some “trigger” phrase indicating therapeutic use. We validated the social media-based findings using a similar analysis on comments to the U.S. Food and Drug Administration’s (FDA) 2019 request-for-comments on cannabis-derived products.
RESULTS: CBD is mostly discussed as a remedy for anxiety disorders and pain and this is consistent across both comment sources. Of comments posted to the CBD subreddit during the monitored time span, 6.19% mentioned anxiety at least once with at least 6.02% of these comments specifically mentioning CBD as a treatment for anxiety (i.e., 0.37% of total comments). The most popular CBD product group is oil and tinctures.
CONCLUSION: Social media surveillance of CBD usage has the potential to surface new therapeutic use-cases as they are posted. Contemporary social media data indicate, for example, that stress and nausea are frequently mentioned as therapeutic use cases for CBD without corresponding evidence, that affirms or denies, in the research literature. However, the abundance of anecdotal claims warrants serious scientific exploration moving forward. Meanwhile, as FDA ponders regulation, our effort demonstrates that social data offers a convenient affordance to surveil for CBD usage patterns in a way that is fast and inexpensive and can inform conventional electronic surveys.

PMID: 32092666 [PubMed – as supplied by publisher]

Social media surveillance for perceived therapeutic effects of cannabidiol (CBD) products.

Cannabis and the exocannabinoid and endocannabinoid systems. Their use and controversies.

Cannabis and the exocannabinoid and endocannabinoid systems. Their use and controversies.

Related Articles

Cannabis and the exocannabinoid and endocannabinoid systems. Their use and controversies.

Gac Med Mex. 2019;155(5):471-474

Authors: Millán-Guerrero RO, Isais-Millán S

Abstract
Cannabis (marijuana) is one of the most consumed psychoactive substances in the world. The term marijuana is of Mexican origin. The primary cannabinoids that have been studied to date include cannabidiol and delta-9-tetrahydrocannabinol, which is responsible for most cannabis physical and psychotropic effects. Recently, the endocannabinoid system was discovered, which is made up of receptors, ligands and enzymes that are widely expressed in the brain and its periphery, where they act to maintain balance in several homeostatic processes. Exogenous cannabinoids or naturally-occurring phytocannabinoids interact with the endocannabinoid system. Marijuana must be processed in a laboratory to extract tetrahydrocannabinol and leave cannabidiol, which is the product that can be marketed. Some studies suggest cannabidiol has great potential for therapeutic use as an agent with antiepileptic, analgesic, anxiolytic, antipsychotic, anti-inflammatory and neuroprotective properties; however, the findings on cannabinoids efficacy and cannabis-based medications tolerability-safety for some conditions are inconsistent. More scientific evidence is required in order to generate recommendations on the use of medicinal cannabis.

PMID: 32091020 [PubMed – in process]

Cannabis and the exocannabinoid and endocannabinoid systems. Their use and controversies.

Smokable Hemp Bill Heads To Virginia Governor's Desk, And Lawmakers Approve Legal …

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Oregon Increases THC Limit for Certain Hemp Products

Oregon just increased hemp products’ max THC per package to 50 mg. To put that into perspective, there’s 50 mg of THC in one Tablespoon of 0.3% THC hempseed oil. But foods are still restricted to 10 mg, meaning every supermarket shelf could supply more THC than the dispensary. What a tangled web they weave when they deceive for 83 years.

Oregon Increases THC Limit for Certain Hemp Products
The Oregon Liquor Control Commission has raised the permissible amount of THC in hemp concentrates, extracts and tinctures.

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Oregon Increases THC Limit for Certain Hemp Products

February 25, 2020 3:38 pm

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Hemp Farm Financing, How To Find Exec Jobs, CyberPatriot Update, Cannabis Tourism

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Decreased sensitivity in adolescent versus adult rats to the antidepressant-like effects of cannabidiol.

Decreased sensitivity in adolescent versus adult rats to the antidepressant-like effects of cannabidiol.

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Decreased sensitivity in adolescent versus adult rats to the antidepressant-like effects of cannabidiol.

Psychopharmacology (Berl). 2020 Feb 21;:

Authors: Bis-Humbert C, García-Cabrerizo R, García-Fuster MJ

Abstract
RATIONALE: Cannabidiol is a non-psychoactive phytocannabinoid with great therapeutic potential in diverse psychiatric disorders; however, its antidepressant potential has been mainly ascertained in adult rats.
OBJECTIVES: To compare the antidepressant-like response induced by cannabidiol in adolescent and adult rats and the possible parallel modulation of hippocampal neurogenesis.
METHODS: Male Sprague-Dawley rats were repeatedly treated with cannabidiol (3, 10, and 30 mg/kg) or vehicle (1 mL/kg) during adolescence (postnatal days, PND 27-33) or adulthood (PND 141-147) and exposed to 3 consecutive tests (forced swim, open field, two-bottle choice) that quantified behavioral despair, anxiety, and sucrose intake respectively.
RESULTS: Cannabidiol induced differential effects depending on the age and dose administered, with a decreased sensitivity observed in adolescent rats: (1) cannabidiol (30 mg/kg) decreased body weight only in adult rats; (2) cannabidiol ameliorated behavioral despair in adolescent and adult rats, but with a different dose sensitivity (10 vs. 30 mg/kg), and with a different extent (2 vs. 21 days post-treatment); (3) cannabidiol did not modulate anxiety-like behavior at any dose tested in adolescent or adult rats; and (4) cannabidiol increased sucrose intake in adult rats.
CONCLUSIONS: Our findings support the notion that cannabidiol exerts antidepressant- and anorexigenic-like effects in adult rats and demonstrate a decreased potential when administered in adolescent rats. Moreover, since cannabidiol did not modulate hippocampal neurogenesis (cell proliferation and early neuronal survival) in adolescent or adult rats, the results revealed potential antidepressant-like effects induced by cannabidiol without the need of regulating hippocampal neurogenesis.

PMID: 32086540 [PubMed – as supplied by publisher]

Decreased sensitivity in adolescent versus adult rats to the antidepressant-like effects of cannabidiol.

ATRA uses hemp fibre and recycled materials for Nerthus-Sofa furniture collection

ATRA uses hemp fibre and recycled materials for Nerthus-Sofa furniture collection Strips of white hemp fabric, a fibre produced from a strain of cannabis, wrap around the frame to form a supportive base. The plant-based textile is also … ATRA uses <b>hemp</b> fibre and recycled materials for Nerthus-Sofa furniture collection February 23, 2020 3:00 pm

CBD Oil Market Size 2020 – Industry Challenges, Key Vendors, Drivers, Trends and Forecast 2026

CBD Oil Market Size 2020 – Industry Challenges, Key Vendors, Drivers, Trends and Forecast 2026 Verified Market Research recently added a research report, the CBD Oil Market Research Report 2020, to its growing repository. The research report … <b>CBD</b> Oil Market Size 2020 – Industry Challenges, Key Vendors, Drivers, Trends and Forecast 2026 February 23, 2020 2:03 pm

Regional Park District, industrial hemp return for supervisor consideration

Regional Park District, industrial hemp return for supervisor consideration FAIRFIELD — Updates on the proposed Dependent Regional Park and Open Space District and regulatory options for industrial hemp go before the … Regional Park District, industrial <b>hemp</b> return for supervisor consideration February 23, 2020 1:30 pm

Geelong CBD 2013 stabbing villian Jovan Van Der Lee wins appeal aginst visa cancellation

Geelong CBD 2013 stabbing villian Jovan Van Der Lee wins appeal aginst visa cancellation A Geelong man jailed for a vicious stabbing in the city's centre will be allowed to remain in Australia after appealing the cancellation of his visa. Geelong <b>CBD</b> 2013 stabbing villian Jovan Van Der Lee wins appeal aginst visa cancellation February 23, 2020 12:56 pm