CannaSearch Breaking News on CBD + Hemp

Hemp meat-free burger now available

Hemp meat-free burger now available
The burger made out of hemp, protein and other grains, which does not get you high, is now available at restaurants in Denver.

https://www.google.com/url?rct=j&sa=t&url=https://kyma.com/news/2019/12/07/hemp-meat-free-burger-now-available/&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNGvN9sNbHJwDGlEFZsNuGgtzqp58g
December 8, 2019 6:11 am
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Budding new business

Budding new business
But Troyer, who grew 7 acres of industrial hemp last year and plans to grow at least 20 this year, intends to do more than grow the crop.

https://www.google.com/url?rct=j&sa=t&url=https://www.goerie.com/business/20191208/budding-new-business&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNF17Vaq4FRmDaG_sqnnTlZif7VdvQ
December 8, 2019 5:15 am
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Continuing issues at Jeannette plant highlight gaps in hemp regulation

Continuing issues at Jeannette plant highlight gaps in hemp regulation
2 minutes ago. Former employees at a Jeannette hemp-drying facility said they worked in unsafe conditions, dealing with thousands of pounds of …

https://www.google.com/url?rct=j&sa=t&url=https://triblive.com/local/westmoreland/continuing-issues-at-jeannette-plant-highlight-gaps-in-hemp-regulation/&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNG4yQK7jxYiTD0kHLtM4UTi-6vKoQ
December 8, 2019 4:52 am
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Christchurch hosts 'world-first' hemp food week

Christchurch hosts 'world-first' hemp food week
Hemp won't get you high but it will make you hungry. Christchurch is hosting Hemp Food Week, a week-long "world-first" celebration where nine …

https://www.google.com/url?rct=j&sa=t&url=https://www.stuff.co.nz/the-press/news/118030413/christchurch-hosts-worldfirst-hemp-food-week&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNFU2JuCFZ3149tmkI4oo6BISpqTFg
December 8, 2019 3:56 am
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New York Hemp Lab Conference discuss problems Hemp business owners face

New York Hemp Lab Conference discuss problems Hemp business owners face
ROCHESTER, NY (WROC)– Hemp experts from around the state gathered in Rochester Saturday to discuss the growing industry. The second annual …

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December 8, 2019 12:11 am
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The truth about CBD skincare

The truth about CBD skincare
Now added to everything from face masks to mascara, CBD, aka cannabidiol, is being touted as the new skincare must-have. But is there really any …

https://www.google.com/url?rct=j&sa=t&url=https://www.thetimes.co.uk/article/the-truth-about-cbd-skincare-ms9t9jsrn&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNHzMTzYTqmkVPaqk9pkCqaMJ05LoQ
December 8, 2019 12:00 am
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Cannabis pioneer Jersey Hemp on a high with £2m funding boost

Cannabis pioneer Jersey Hemp on a high with £2m funding boost
The first company in the British Isles to win a licence to harvest hemp flowers for cannabis oil has raised £2m, as investors rush to plough money into …

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December 8, 2019 12:00 am
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4-year-old boy shot and killed in Alabama, suspect in custody

4-year-old boy shot and killed in Alabama, suspect in custody
These companies cover the waterfront of CBD and hemp products, derived from the cannabis plant but without the psychoactive chemical THC, …

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December 7, 2019 11:48 pm
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American-Alb Hemp Company

American-Alb Hemp Company
The American-Alb Hemp Company (AAHC) was founded in 2014 to establish the industrial hemp industry in Albania. —– The American-Albanian …

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December 7, 2019 11:41 pm
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Cannabidiol Cuts Seizures in Another Rare Epilepsy

Cannabidiol Cuts Seizures in Another Rare Epilepsy
BALTIMORE — Adjunctive cannabidiol, or CBD, (Epidiolex) met its primary endpoint of reducing seizures in patients with tuberous sclerosis complex …

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December 7, 2019 11:37 pm
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Real Nano CBD Hemp Shop – 2019 All You Need to Know BEFORE You Go (with Photos …

Real Nano CBD Hemp Shop – 2019 All You Need to Know BEFORE You Go (with Photos …
Nano CBD is offering an advanced method of delivery to provide pure and high quality relief from hemp derived CBD with our patented technology, …

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December 7, 2019 9:52 pm
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Kansas Hemp Growers

Kansas Hemp Growers
Kansas Hemp Growers is growing CBD hemp under the new Kansas Department of Agriculture Research Program. We are growing organic, high …

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December 7, 2019 8:21 pm
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Eye Catching Stock:: Hemp Naturals (OTC:HPMM)

Eye Catching Stock:: Hemp Naturals (OTC:HPMM)
Hemp Naturals (OTC:HPMM) STOCK IN FOCUS: Overbought and Oversold levels. The stock has RSI reading of 40.16. RSI gives an indication of the …

https://www.google.com/url?rct=j&sa=t&url=https://webnewsobserver.com/2019/12/07/eye-catching-stock-hemp-naturals-otchpmm/&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNFvKMeFH7VH00ptPboLEviQy22TSg
December 7, 2019 7:47 pm
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Compensation of matrix effects in seed matrices followed by gas chromatography-tandem mass spectrometry analysis of pesticide residues.

Compensation of matrix effects in seed matrices followed by gas chromatography-tandem mass spectrometry analysis of pesticide residues.

Related Articles

Compensation of matrix effects in seed matrices followed by gas chromatography-tandem mass spectrometry analysis of pesticide residues.

J Chromatogr A. 2019 Nov 26;:460738

Authors: Rutkowska E, Łozowicka B, Kaczyński P

Abstract
Despite analytical advances, matrix effects (MEs) in pesticide residue analysis by gas chromatography – tandem mass spectrometry continue to be a challenge, especially in difficult samples such as seeds. In this study, the influence of different clean-up sorbents (chitin, chitosan, Z-Sep+, EMR-Lipid) and different mixtures of primary secondary amine (PSA), C18, graphitized carbon black (GCB) and MgSO4 were investigated in terms of MEs and recoveries in four types of seeds: cress, fennel, flax, and hemp. Additionally, different volumes of water (5, 7.5 and 10 mL) were investigated for QuEChERS extraction. Under the selected conditions: the largest volume of water (10 mL) and PSA/C18/GCB/MgSO4 (50/150/50/50 mg, respectively) as clean-up sorbent yielded acceptable recoveries of 70-120% for most of the pesticides (211-225 out of 248 compounds) and the lowest MEs were between -20%>MEs>20% (27-50 compounds). The final method was validated for 248 pesticides with LOQs equal to 0.005 mg kg-1. Additionally, matrix-matched calibration was used as a practical method to compensate for MEs. Among the 21 pesticides found in 12 of the samples, chlorpyrifos (0.008-1.1 mg kg-1), tebuconazole (0.071-0.96 mg kg-1), and trifloxystrobin (0.007-0.15 mg kg-1) were most commonly determined.

PMID: 31806271 [PubMed – as supplied by publisher]


https://www.ncbi.nlm.nih.gov/pubmed/31806271?dopt=Abstract

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/erss.cgi?rss_guid=12OY-2YuXEtecDR7WE-A2c-rtPCJqs0e275YvMbwhvRR34bgib
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Hempcrete — the eco-friendly material breathing new life into Australian homes

Hempcrete — the eco-friendly material breathing new life into Australian homes
Hempcrete, made from mixing woody hemp fibre (from inside the hemp stalk), with lime and water, is then pushed into timber frames by hand to build …

https://www.google.com/url?rct=j&sa=t&url=https://www.abc.net.au/news/rural/2019-12-08/carbon-neutral-hempcrete-homes-building-in-popularity/11769446&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNEc9182jwmpGl5-Si2laN1usfif1Q
December 7, 2019 7:31 pm
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Judge: South Carolina hemp farmer's crop must be protected

Judge: South Carolina hemp farmer's crop must be protected
CHARLESTON, S.C. (AP) — A judge is allowing a South Carolina hemp farmer arrested after authorities said he grew the crop in unregistered fields to …

https://www.google.com/url?rct=j&sa=t&url=https://www.sfchronicle.com/news/crime/article/Judge-South-Carolina-hemp-farmer-s-crop-must-be-14889730.php&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNFSULtrdHRRKXW52PJTf_VDFN2chQ
December 7, 2019 7:07 pm
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State grain-protection requirements apply if low-THC hemp becomes legal in South Dakota

State grain-protection requirements apply if low-THC hemp becomes legal in South Dakota
PIERRE, S.D. (KELO) — Industrial hemp would be covered by state grain-warehouse and grain-buyer laws if it becomes legal in South Dakota, a state …

https://www.google.com/url?rct=j&sa=t&url=https://www.keloland.com/news/capitol-news-bureau/state-grain-protection-requirements-apply-if-low-thc-hemp-becomes-legal-in-south-dakota/&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNEBHUenX0x9q0NJKxAi5qhWUGsX1A
December 7, 2019 6:45 pm
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Global Industrial Hemp Market Insights Focusing on Primary Trends Until 2026

Global Industrial Hemp Market Insights Focusing on Primary Trends Until 2026
GMI Research has recently published a report on Global Industrial Hemp market, the report highlights the key ongoing market trend, market growth, …

https://www.google.com/url?rct=j&sa=t&url=https://dentonchronicle.com/2019/12/07/global-industrial-hemp-market-insights-focusing-on-primary-trends-until-2026/&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNGIAoSa769qaL2PWIlXKU-P61pPcg
December 7, 2019 6:11 pm
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Global Hemp Fiber Market 2019 – HempFlax , Cavac Biomatériaux , BaFa , Hemp Planet …

Global Hemp Fiber Market 2019 – HempFlax , Cavac Biomatériaux , BaFa , Hemp Planet …
Global Hemp Fiber Market 2019 report contains wide-extending measurable details of Global Hemp Fiber Market, which enables the customer to …

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December 7, 2019 5:58 pm
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90 minutes until our CBD informational… – Chatham Marketplace

90 minutes until our CBD informational… – Chatham Marketplace
90 minutes until our CBD informational session with Judy from Broadway Hemp Company. Don't miss it!

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December 7, 2019 5:30 pm
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Greenwich Biosciences, a GW Pharmaceuticals Company, Presents New Data for EPIDIOLEX …

Greenwich Biosciences, a GW Pharmaceuticals Company, Presents New Data for EPIDIOLEX …
Greenwich Biosciences, a GW Pharmaceuticals Company, Presents New Data for EPIDIOLEX® (cannabidiol) in Patients with Tuberous Sclerosis …

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December 7, 2019 5:03 pm
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The Flat House review – a home made from hemp that will blow your mind

The Flat House review – a home made from hemp that will blow your mind
Among the many uses of hemp, the plant from which the drug comes – uses that include ropes, clothes, food and medicine – was the fabric for the …

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December 7, 2019 4:52 pm
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Your Hemp Questions Answered

Your Hemp Questions Answered
Last month, Daniel Shortt and I put on a webinar on the US Department of Agriculture's ("USDA") new interim hemp rules. We got some great …

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December 7, 2019 3:22 pm
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As more pro athletes use cannabis for aches and pain, the more they run afoul of rules

As more pro athletes use cannabis for aches and pain, the more they run afoul of rules
All because she used a topical cream containing CBD (cannabidiol) for pain caused by a stress fracture in her foot. There's a tiny bit of THC in almost …

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December 7, 2019 3:11 pm
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Global Hemp Spinning Market Analysis by Top Key Players 2019 – 2025 : Oerlikon, Rieter, Picanol …

Global Hemp Spinning Market Analysis by Top Key Players 2019 – 2025 : Oerlikon, Rieter, Picanol …
The Global Hemp Spinning Market report offers in-depth analysis and insights into developments impacting businesses and enterprises on global …

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December 7, 2019 11:43 am
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Global Industrial Hemp Market Growth, Insights Analysis, Forecasts to 2025 – GoFire, ICC, PIHG …

Global Industrial Hemp Market Growth, Insights Analysis, Forecasts to 2025 – GoFire, ICC, PIHG …
The Global Industrial Hemp Market report offers in-depth analysis and insights into developments impacting businesses and enterprises on global …

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December 7, 2019 11:03 am
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Global CBD Hemp Oil Market 2019 Industry Key Players, Trends, Sa

Global CBD Hemp Oil Market 2019 Industry Key Players, Trends, Sa
This report provides in depth study of “CBD Hemp Oil Market” using SWOT analysis i.e. Strength, Weakness, Opportunities and Threat to the …

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December 7, 2019 10:40 am
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CBD Disclosure

CBD Disclosure
CBD DISCLOSURE. All Hemp-Derived Cannabinol Products (the “Products”) for sale on this website and the statements made regarding the Products …

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December 7, 2019 10:05 am
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Are You Confused About CBD?

Are You Confused About CBD?
It's been a year since the 2018 Farm Bill legalized hemp, but the legal status of hemp-derived cannabidiol remains in limbo since CBD can be derived …

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December 7, 2019 7:43 am
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New hemp farm plans open house

New hemp farm plans open house
Western Farms Seed Company is investigating the potential market possibilities for industrial hemp. These plants are among the first indoor growth at …

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December 7, 2019 7:30 am
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CBD research trends in 2019

CBD research trends in 2019
It's getting easier for CBD researchers to conduct studies of cannabidiol. Here are some developing trends in CBD research that bear watching.

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December 7, 2019 7:22 am
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Turmeric and 99.9% 3rd party tested Hemp Extract Tonic inflammation, anxiety, stress

Turmeric and 99.9% 3rd party tested Hemp Extract Tonic inflammation, anxiety, stress
Description. Tumeric is a traditional Indian spice which has always been in high demand. It contains many curcuminoids, the most important being …

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December 7, 2019 6:09 am
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Hemp putting down more roots in Las Cruces as startup firm plans to employ 55

Hemp putting down more roots in Las Cruces as startup firm plans to employ 55
LAS CRUCES, New Mexico — The hemp revolution continues in New Mexico, with the potential for a sustainable crop that boosts jobs, local …

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December 7, 2019 5:37 am
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mu extension scheduled to offer workshop on industrial hemp production

mu extension scheduled to offer workshop on industrial hemp production
University of Missouri Extension in Saline County is scheduled to offer a workshop on industrial hemp production. A news release says the free event …

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December 7, 2019 4:47 am
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CBD You Can Trust

CBD You Can Trust
Brecken Gold Hemp provides the finest-quality hemp-derived full-spectrum CBD oil products in America—from edible gummies to oil tincture and …

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December 7, 2019 3:48 am
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Hemp Oil

Hemp Oil
Premier Research Labs; founded to deliver uncompromising quality & effectiveness, providing 100% non-toxic products, designed to deliver the very …

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December 7, 2019 3:23 am
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B1G1 50% Off All CBD + Hemp Items

B1G1 50% Off All CBD + Hemp Items
Shop in store buy 1, get 1 50% off on all CBD + hemp items. Some restrictions may apply. Offer details and dates may vary by location. See store for …

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December 7, 2019 2:44 am
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Canopy Growth Drops $13M Fraud Suit Against Hemp Farmer

Canopy Growth Drops $13M Fraud Suit Against Hemp Farmer
Law360 (December 6, 2019, 8:19 PM EST) — The U.S. arm of Canadian cannabis behemoth Canopy Growth on Friday dropped its claims that a hemp …

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December 7, 2019 1:18 am
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Idaho Farm Bureau reaffirms support for industrial hemp

Idaho Farm Bureau reaffirms support for industrial hemp
Idaho Farm Bureau Federation delegates reaffirmed their support for industrial hemp during the origination's 80th annual meeting Dec. 3-5 in Coeur …

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December 7, 2019 12:45 am
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Nebraska hemp growers getting closer to harvesting

Nebraska hemp growers getting closer to harvesting
PLATTSMOUTH, Neb. (KMTV) — The hemp plant was known to be used thousands of years ago, but the hemp industry in Nebraska is still very new.

https://www.google.com/url?rct=j&sa=t&url=https://www.3newsnow.com/news/local-news/nebraska-hemp-growers-getting-closer-to-harvesting&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNFEqY5IPyWNc_8yfNHTTCsVYM7T1g
December 7, 2019 12:45 am
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Former Seahawk Lofa Tatupu advocates for CBD after retirement

Former Seahawk Lofa Tatupu advocates for CBD after retirement
Lofa Tatupu is making headlines again, but not for his football success. Instead, the former Seahawks linebacker is advocating for CBD and hemp …

https://www.google.com/url?rct=j&sa=t&url=https://www.king5.com/article/news/local/take-5/former-seahawk-lofa-tatupu-advocates-for-cbd-after-retirement/281-fdcd1377-7e86-43cd-ab5d-e1e8df2fce49&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNGHXVgQ9LtvQ9a1nd7JwXPyV62nMA
December 7, 2019 12:33 am
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Legislators and more attend public hemp forum at Black Hills State University

Legislators and more attend public hemp forum at Black Hills State University
In attendance was an actual hemp farmer, Nevada Ellison, who farms in the Southeast corner of the state of North Dakota. His experience is that hemp …

https://www.google.com/url?rct=j&sa=t&url=https://www.newscenter1.tv/legislators-and-more-attend-public-hemp-forum-at-black-hills-state-university/&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNGzNh-5HF4PL9J4QcS-KA20ATAXCg
December 6, 2019 11:48 pm
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CBD Doggy Nugs

CBD Doggy Nugs
MADE IN USA: Treat your doggy to CBD American Shaman's Full Spectrum Hemp Extract Doggy Nugs. Made with real chicken, it is sure to keep tails …

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December 6, 2019 11:05 pm
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Blazing hot: Colorado company makes burger from hemp. And no, it won't get you high

Blazing hot: Colorado company makes burger from hemp. And no, it won't get you high
DENVER — The demand for meat-free burgers is intersecting with Colorado's booming hemp industry to create a patty that starts with cannabis plants.

https://www.google.com/url?rct=j&sa=t&url=https://www.thedenverchannel.com/money/consumer/blazing-hot-colorado-company-makes-burger-from-hemp-and-no-it-wont-get-you-high&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNFB2SGgPc4-Fe_lMFRENGXcPdtbYQ
December 6, 2019 10:41 pm
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Brazilian court approves commercial hemp cultivation for one company

Brazilian court approves commercial hemp cultivation for one company
A company in Brazil successfully appealed to a court for permission to cultivate hemp on the same day that the Brazilian government decided against …

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December 6, 2019 9:33 pm
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New CBD Store Opening Soon In Wading River

New CBD Store Opening Soon In Wading River
The first retail location of Noids Botanicals, a CBD and hemp wellness store, will have its grand opening on Saturday, Dec. 14 at The Shoppes at East …

https://www.google.com/url?rct=j&sa=t&url=https://patch.com/new-york/riverhead/new-cbd-store-opening-soon-wading-river&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNFJvTLY_blnLi8o1OrhiPHlYEjeXw
December 6, 2019 9:11 pm
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Barr's efforts lead to new hemp banking guidance

Barr's efforts lead to new hemp banking guidance
U.S. Rep. Andy Barr (R-KY) applauded new federal guidance clarifying the legality of industrial hemp and relaxing the requirements for banks doing …

https://www.google.com/url?rct=j&sa=t&url=https://riponadvance.com/stories/barrs-efforts-lead-to-new-hemp-banking-guidance/&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNEanlx_WOWgYOTp4VJaMQ8F2H6d3g
December 6, 2019 8:48 pm
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Lawyer: Feds clear path for hemp business banking, but difficulties remain

Lawyer: Feds clear path for hemp business banking, but difficulties remain
Federal banking regulators removed restrictions against banking industrial hemp businesses this week, but banks probably will continue to treat them …

https://www.google.com/url?rct=j&sa=t&url=https://www.bizjournals.com/kansascity/news/2019/12/06/industrial-hemp-industry-federal-banking-rules.html&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNG-qF1Y1lrqcZ4u4jf2gdlXTrrHqQ
December 6, 2019 8:37 pm
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FDA Cracks Down on Companies Selling CBD Products

FDA Cracks Down on Companies Selling CBD Products
The past year has seen a veritable tidal wave of consumer product marketing claiming that cannabidiol (CBD) infused or derived products cure or treat …

https://www.google.com/url?rct=j&sa=t&url=https://www.bhfs.com/insights/alerts-articles/2019/fda-cracks-down-on-companies-selling-cbd-products&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNHBPYDdicp6y5ABGfjnUJ-Mx4MSag
December 6, 2019 8:27 pm
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UW Extension educator: hemp a risk vs. reward scenario

UW Extension educator: hemp a risk vs. reward scenario
TORRINGTON — While hemp advocates are quick to point out that the cannabis sativa cultivar can be used for thousands of products ranging from …

https://www.google.com/url?rct=j&sa=t&url=https://www.laramieboomerang.com/news/uw-extension-educator-hemp-a-risk-vs-reward-scenario/article_a46e08a6-7b85-5c3d-863f-8cde326f574a.html&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNESmow0aWX0hvxFzQgN_4WddpIqLA
December 6, 2019 8:03 pm
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Effects of O-1602 and CBD on TNBS-induced colonic disturbances.

Effects of O-1602 and CBD on TNBS-induced colonic disturbances.

Related Articles

Effects of O-1602 and CBD on TNBS-induced colonic disturbances.

Neurogastroenterol Motil. 2019 Dec 04;:e13756

Authors: Wei D, Wang H, Yang J, Dai Z, Yang R, Meng S, Li Y, Lin X

Abstract
BACKGROUND: This study attempted to provide the effects and mechanisms of two cannabinoids, O-1602 and cannabidiol (CBD), on colonic motility of 2,4,6-trinitro-benzene sulfonic acid (TNBS) colitis.
METHODS: TNBS was used to induce the model of motility disorder. G protein-coupled receptor 55 (GPR55) expression was detected using real-time PCR and immunohistochemistry in colon. Pro-inflammatory cytokines and myeloperoxidase were also measured. The colonic motility was measured by upper GI transit in vivo and recorded using electrical stimulation organ bath technique in vitro. Freshly isolated smooth muscle from the rat colon were applied to determine the membrane potential and Ca2+ -ATPase activity, respectively.
KEY RESULTS: CBD or O-1602 separately improved inflammatory conditions significantly in TNBS-induced colitis rats. However, sole CBD pretreatment reduced GPR55 expression, which was up-regulated in TNBS colitis. O-1602 and CBD each lowered MPO and IL-6 levels remarkably in TNBS colitis, while TNF-α levels experienced no change. CBD rescued the downward colonic motility in TNBS colitis in vivo; however, it decreased the upward contraction of the smooth muscle strip under electrical stimulation in vitro. Pretreatment with CBD prevented against TNBS-induced changes of Ca2+ -ATPase activity of smooth muscle cells. However, membrane potential of the smooth muscle cells decreased by TNBS experienced no change after O-1602 or CBD import.
CONCLUSIONS & INFERENCES: The present study suggested that CBD participated in the regulation of colonic motility in rats, and the mechanisms may be involved in the regulation of inlammatory factors and Ca2+ -ATPase activity through GPR55.

PMID: 31802588 [PubMed – as supplied by publisher]


https://www.ncbi.nlm.nih.gov/pubmed/31802588?dopt=Abstract

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/erss.cgi?rss_guid=1jYCQzi_o_qLYr-oQfnMhShgOXkvGma3vcnBGJtrBhuJMOvEVJ
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Lifestyle of a Roman Imperial community: ethnobotanical evidence from dental calculus of the Ager Curensis inhabitants.

Lifestyle of a Roman Imperial community: ethnobotanical evidence from dental calculus of the Ager Curensis inhabitants.

Related Articles

Lifestyle of a Roman Imperial community: ethnobotanical evidence from dental calculus of the Ager Curensis inhabitants.

J Ethnobiol Ethnomed. 2019 Dec 04;15(1):62

Authors: D’Agostino A, Gismondi A, Di Marco G, Lo Castro M, Olevano R, Cinti T, Leonardi D, Canini A

Abstract
BACKGROUND: The analysis of ancient calcified dental plaque is a powerful archaeobotanical method to elucidate the key role of the plants in human history.
METHODS: In this research, by applying both optic microscopy and gas chromatography mass spectrometry on this matrix, a detailed qualitative investigation for reconstructing the lifestyle of a Roman imperial community of the Ager Curensis (Sabina Tiberina, Central Italy) was performed.
RESULTS: The detection of animal micro-remains and molecules (e.g., hairs, feather barbules, markers of dairy products), starch granules of several cereals and legumes, pollen (e.g., Juglans regia L., Hedera sp. L.) and other plant micro-debris (e.g., trichome of Olea sp., hemp fibers), and phytochemicals (e.g., Brassicaceae, Lamiaceae herbs, Ferula sp., Trigonella foenum-graecum L., wine, and Humulus lupulus L.) in the dental calculus sample demonstrated that plant-derived foods were regularly consumed together with animal resources.
CONCLUSIONS: This nutritional plan, consistent with the information reported in ancient written texts, suggested that the studied population based its own subsistence on both agriculture and husbandry, probably also including beekeeping and hunting activities. All together, these results represent proofs for the comprehension of food habits, phytotherapeutic practices, and cultural traditions of one of the first Roman settlements in the Sabina Tiberina area.

PMID: 31801550 [PubMed – in process]


https://www.ncbi.nlm.nih.gov/pubmed/31801550?dopt=Abstract

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/erss.cgi?rss_guid=12OY-2YuXEtecDR7WE-A2c-rtPCJqs0e275YvMbwhvRR34bgib
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Transcriptomic Analysis of Stem Cells Treated with Moringin or Cannabidiol: Analogies and Differences in Inflammation Pathways.

Transcriptomic Analysis of Stem Cells Treated with Moringin or Cannabidiol: Analogies and Differences in Inflammation Pathways.

Related Articles

Transcriptomic Analysis of Stem Cells Treated with Moringin or Cannabidiol: Analogies and Differences in Inflammation Pathways.

Int J Mol Sci. 2019 Nov 30;20(23):

Authors: Chiricosta L, Silvestro S, Pizzicannella J, Diomede F, Bramanti P, Trubiani O, Mazzon E

Abstract
Inflammation is a common feature of many neurodegenerative diseases. The treatment of stem cells as a therapeutic approach to repair damage in the central nervous system represents a valid alternative. In this study, using Next-Generation Sequencing (NGS) technology, we analyzed the transcriptomic profile of human Gingival Mesenchymal Stem Cells (hGMSCs) treated with Moringin [4-(α-l-ramanosyloxy)-benzyl isothiocyanate] (hGMSCs-MOR) or with Cannabidiol (hGMSCs-CBD) at dose of 0.5 or 5 µM, respectively. Moreover, we compared their transcriptomic profiles in order to evaluate analogies and differences in pro- and anti-inflammatory pathways. The hGMSCs-MOR selectively downregulate TNF-α signaling from the beginning, reducing the expression of TNF-α receptor while hGMSCs-CBD limit its activity after the process started. The treatment with CBD downregulates the pro-inflammatory pathway mediated by the IL-1 family, including its receptor while MOR is less efficient. Furthermore, both the treatments are efficient in the IL-6 signaling. In particular, CBD reduces the effect of the pro-inflammatory JAK/STAT pathway while MOR enhances the pro-survival PI3K/AKT/mTOR. In addition, both hGMSCs-MOR and hGMSCs-CBD improve the anti-inflammatory activity enhancing the TGF-β pathway.

PMID: 31801206 [PubMed – in process]


https://www.ncbi.nlm.nih.gov/pubmed/31801206?dopt=Abstract

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/erss.cgi?rss_guid=1BE6Yf6ex8r6DRZaKzQi_iKP-GeW6jP4zTLhuJ2dzIMGHW_IGQ
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Cannabinoids and the Microbiota-Gut-Brain-Axis: Emerging Effects of Cannabidiol and Potential Applications to Alcohol Use Disorders.

Cannabinoids and the Microbiota-Gut-Brain-Axis: Emerging Effects of Cannabidiol and Potential Applications to Alcohol Use Disorders.

Related Articles

Cannabinoids and the Microbiota-Gut-Brain-Axis: Emerging Effects of Cannabidiol and Potential Applications to Alcohol Use Disorders.

Alcohol Clin Exp Res. 2019 Dec 05;:

Authors: Karoly HC, Mueller RL, Bidwell LC, Hutchison KE

Abstract
The endocannabinoid system (ECS) has emerged in recent years as a potential treatment target for alcohol use disorders (AUD). In particular, the non-psychoactive cannabinoid cannabidiol (CBD) has shown preclinical promise in ameliorating numerous clinical symptoms of AUD. There are several proposed mechanism(s) through which cannabinoids (and CBD in particular) may confer beneficial effects in the context of AUD. First, CBD may directly impact specific brain mechanisms underlying AUD to influence alcohol consumption and the clinical features of AUD. Second, CBD may influence AUD symptoms through its actions across the digestive, immune, and central nervous systems, collectively known as the microbiota-gut-brain-axis (MGBA). Notably, emerging work suggests that alcohol and cannabinoids exert opposing effects on the MGBA. Alcohol is linked to immune dysfunction (e.g., chronic systemic inflammation in the brain and periphery) as well as disturbances in gut microbial species (microbiota) and increased intestinal permeability. These MGBA disruptions have been associated with AUD symptoms such as craving and impaired cognitive control. Conversely, existing preclinical data suggest that cannabinoids may confer beneficial effects on the gastrointestinal and immune system, such as reducing intestinal permeability, regulating gut bacteria and reducing inflammation. Thus, cannabinoids may exert AUD harm-reduction effects, at least in part, through their beneficial actions across the MGBA. This review will provide a brief introduction to the ECS and the MGBA, discuss the effects of cannabinoids (particularly CBD) and alcohol in the brain, gut, and immune system (i.e., across the MGBA), and put forth a theoretical framework to inform future research questions.

PMID: 31803950 [PubMed – as supplied by publisher]


https://www.ncbi.nlm.nih.gov/pubmed/31803950?dopt=Abstract

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/erss.cgi?rss_guid=1BE6Yf6ex8r6DRZaKzQi_iKP-GeW6jP4zTLhuJ2dzIMGHW_IGQ
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A Phase I, Open-Label, Parallel-Group, Single-Dose Trial of the Pharmacokinetics, Safety, and Tolerability of Cannabidiol in Subjects with Mild to Severe Renal Impairment.

A Phase I, Open-Label, Parallel-Group, Single-Dose Trial of the Pharmacokinetics, Safety, and Tolerability of Cannabidiol in Subjects with Mild to Severe Renal Impairment.

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A Phase I, Open-Label, Parallel-Group, Single-Dose Trial of the Pharmacokinetics, Safety, and Tolerability of Cannabidiol in Subjects with Mild to Severe Renal Impairment.

Clin Pharmacokinet. 2019 Dec 05;:

Authors: Tayo B, Taylor L, Sahebkar F, Morrison G

Abstract
INTRODUCTION: As patients who receive cannabidiol (CBD) may have co-existing renal morbidities, it is important to understand whether dose adjustments are necessary to mitigate the risk of exposure-related toxicity. This study was conducted to evaluate the pharmacokinetics, safety, and tolerability of CBD in patients with renal impairment.
METHODS: The pharmacokinetics and safety of a single oral 200 mg dose of a plant-derived pharmaceutical formulation of highly purified CBD in oral solution (Epidiolex® in the USA; 100 mg/mL) were assessed in subjects with mild, moderate, or severe renal impairment (n = 8/group) relative to matched subjects with normal renal function (n = 8). Blood samples were collected until 48 h post-dose and evaluated by liquid chromatography with tandem mass spectrometry. Analysis of variance was used to compare primary pharmacokinetic parameters (maximum measured plasma concentration [Cmax], oral clearance of drug from plasma [CL/F], renal clearance [CLR], area under the plasma concentration-time curve [AUC] from time zero to last measurable concentration [AUCt], and AUC from time zero to infinity [AUC∞]); descriptive analysis was used for secondary pharmacokinetic parameters (time to Cmax [tmax], terminal [elimination] half-life [t½], cumulative amount excreted from time zero to the last quantifiable sample [Aelast], and fraction of the systemically available drug excreted into the urine [fe]).
RESULTS: No statistically significant differences were observed in Cmax, AUCt, AUC∞, or tmax values between subjects with mild, moderate, or severe renal impairment and subjects with normal renal function for CBD or its major metabolites, 7-carboxy-CBD (7-COOH-CBD) and 7-hydroxy-CBD (7-OH-CBD), and minor metabolite, 6-hydroxy-CBD (6-OH-CBD); geometric mean ratio for Cmax values ranged from 0.68 to 1.35. No differences were observed for other secondary parameters (Aelast and fe). CBD, 7-COOH-CBD, 7-OH-CBD, and 6-OH-CBD were highly protein bound (> 90%); binding was similar in all subject groups. Urine analysis for CBD recorded no appreciable amount, and thus no urinary pharmacokinetic parameters could be derived. Adverse events (AEs) affected two subjects; all five AEs were mild in severity and resolved during the trial. There were no serious AEs or discontinuations due to AEs. Laboratory, physical examination, vital sign, and 12-lead electrocardiogram findings were not clinically significant.
CONCLUSION: Renal impairment had no effect on the metabolism of CBD after a single oral 200 mg dose. CBD was generally well tolerated in subjects with varying degrees of renal function.
REGISTRATION: European Union Clinical Trials Register (EudraCT) no. 2015-002122-39.

PMID: 31802404 [PubMed – as supplied by publisher]


https://www.ncbi.nlm.nih.gov/pubmed/31802404?dopt=Abstract

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/erss.cgi?rss_guid=1BE6Yf6ex8r6DRZaKzQi_iKP-GeW6jP4zTLhuJ2dzIMGHW_IGQ
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Effects of O-1602 and CBD on TNBS-induced colonic disturbances.

Effects of O-1602 and CBD on TNBS-induced colonic disturbances.

Related Articles

Effects of O-1602 and CBD on TNBS-induced colonic disturbances.

Neurogastroenterol Motil. 2019 Dec 04;:e13756

Authors: Wei D, Wang H, Yang J, Dai Z, Yang R, Meng S, Li Y, Lin X

Abstract
BACKGROUND: This study attempted to provide the effects and mechanisms of two cannabinoids, O-1602 and cannabidiol (CBD), on colonic motility of 2,4,6-trinitro-benzene sulfonic acid (TNBS) colitis.
METHODS: TNBS was used to induce the model of motility disorder. G protein-coupled receptor 55 (GPR55) expression was detected using real-time PCR and immunohistochemistry in colon. Pro-inflammatory cytokines and myeloperoxidase were also measured. The colonic motility was measured by upper GI transit in vivo and recorded using electrical stimulation organ bath technique in vitro. Freshly isolated smooth muscle from the rat colon were applied to determine the membrane potential and Ca2+ -ATPase activity, respectively.
KEY RESULTS: CBD or O-1602 separately improved inflammatory conditions significantly in TNBS-induced colitis rats. However, sole CBD pretreatment reduced GPR55 expression, which was up-regulated in TNBS colitis. O-1602 and CBD each lowered MPO and IL-6 levels remarkably in TNBS colitis, while TNF-α levels experienced no change. CBD rescued the downward colonic motility in TNBS colitis in vivo; however, it decreased the upward contraction of the smooth muscle strip under electrical stimulation in vitro. Pretreatment with CBD prevented against TNBS-induced changes of Ca2+ -ATPase activity of smooth muscle cells. However, membrane potential of the smooth muscle cells decreased by TNBS experienced no change after O-1602 or CBD import.
CONCLUSIONS & INFERENCES: The present study suggested that CBD participated in the regulation of colonic motility in rats, and the mechanisms may be involved in the regulation of inlammatory factors and Ca2+ -ATPase activity through GPR55.

PMID: 31802588 [PubMed – as supplied by publisher]


https://www.ncbi.nlm.nih.gov/pubmed/31802588?dopt=Abstract

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/erss.cgi?rss_guid=1BE6Yf6ex8r6DRZaKzQi_iKP-GeW6jP4zTLhuJ2dzIMGHW_IGQ
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Cannabidiol (CBD) for Treatment of Neurofibromatosis-related Pain and Concomitant Mood Disorder

Cannabidiol (CBD) for Treatment of Neurofibromatosis-related Pain and Concomitant Mood Disorder
Cannabidiol (CBD) is the major non-psychotropic component of cannabis. CBD has shown anti-inflammatory and analgesic properties, as well as …

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Drugs for dogs! New Park Slope CBD vendor offers a whole line of pooch products.

Drugs for dogs! New Park Slope CBD vendor offers a whole line of pooch products.
Park Slope's newest CBD retailer carries hemp-derived products tailor-made for man's best friend — offering a natural way for nervous pups to wind …

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First Look at How CBD Products Performed in 2019

First Look at How CBD Products Performed in 2019
While the webinar covered both marijuana and hemp/CBD, it focused much attention on the latter, which Nielsen estimates will hit sales of $900 …

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WI financial institutions get clarity on hemp banking rules

WI financial institutions get clarity on hemp banking rules
MADISON, Wis. — Financial institutions will no longer have to take extra steps in order to accept customers involved in the hemp industry. Federal …

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Federal Agencies Clarify Banking Rules For Hemp Businesses

Federal Agencies Clarify Banking Rules For Hemp Businesses
On Oct. 29, the United States Department of Agriculture released its long-awaited draft regulations for hemp production. On Dec. 3, four federal …

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Bluebird Botanicals Becomes One Of The First CBD Companies To Earn B Corp™ Certification

Bluebird Botanicals Becomes One Of The First CBD Companies To Earn B Corp™ Certification
6, 2019 /PRNewswire/ — Bluebird Botanicals, a family-owned, industry-leading manufacturer and distributor of high-quality hemp extracts, CBD oils …

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Hemp takes center stage at Hermiston Farm Fair

Hemp takes center stage at Hermiston Farm Fair
As hemp continues to gain ground across Oregon, scientists and regulators presented their latest findings about the versatile plant during a half-day …

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Vita Coco Launches Hemp Coconut Water

Vita Coco Launches Hemp Coconut Water
We've seen CBD seltzers and cocktails entering the market, but now there's an even more hydrating option for hemp drinkers: coconut water.

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A Year Of Growing Hemp

A Year Of Growing Hemp
It's been nearly one year since President Trump signed the Agriculture Improvement Act of 2018, making it legal to grow industrial hemp in the U.S. for …

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The Healing Sole founders launch hemp wellness company

The Healing Sole founders launch hemp wellness company
Dr. Meredith Warner and Natalie Noel, founders of The Healing Sole, have launched a new hemp wellness company, The Well Theory. The company …

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New business owner discovers local need for CBD products

New business owner discovers local need for CBD products
When Lisa Lintner, owner of Releaf Ology in Little Falls, first opened her store, she wasn't sure how well her Cannabidiol (CBD) products would sell.

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How CBD may help athletes recover from strain and manage pain

How CBD may help athletes recover from strain and manage pain
In the wake of the recent opioid crisis, cannabidiol appears to have become a promising super drug that may lower opioid dependence. Now, CBD …

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Should I try CBD?

Should I try CBD?
Cannabidiol, or CBD, is commonly used to treat insomnia, anxiety and pain, but both the short- and long-term effects of the hemp-derived drug are …

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A snack chip launches a food revolution

A snack chip launches a food revolution
But that was before Goose, the former chief marketing officer at food behemoth Hain Celestial, tasted his friend Chadwick White's new hemp seed …

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CO Hemp Plan

CO Hemp Plan
And he says while he gets calls from hemp administrators from around the country looking to see how Colorado has created it's program, there's still a …

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T1 hemp flower

T1 hemp flower
The upright growth habit and the flower structure due to short SKU: N/A Category: CBD Flower Tag: cbg hemp flower We recommend …

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Trends in use, pharmacology and clinical applications of emerging herbal nutraceuticals.

Trends in use, pharmacology and clinical applications of emerging herbal nutraceuticals.

Related Articles

Trends in use, pharmacology and clinical applications of emerging herbal nutraceuticals.

Br J Pharmacol. 2019 Dec 04;:

Authors: Williamson EM, Liu X, Izzo AA

Abstract
The nutraceuticals market is vast and amorphous, encompassing many different types of products from a wide range of sources, with inconsistent levels of evidence available to support their use. This overview represents a mainly Western perspective of trends in the nutraceuticals market, with a brief comparison of the situation in China, as an illustration of how individual health supplements increase and decrease in popularity in regional terms. Recent changes in sales patterns, mainly taken from the US market, are summarised, and a selection of 5 newer products which have not been subject to extensive recent review are profiled: Astaxanthin, a carotenoid found in red algae and seafood, salmon, and trout, as an antioxidant; Cannabidiol, a non-euphoric marijuana component, as mood enhancer and for painful/inflammatory conditions; Ginseng modified extracts for new indications including dementia and space travel support; Monk fruit, a non-sugar high intensity sweetener, and Nigella seed, a popular food ingredient and Asian medicine which has experienced an extraordinary rise in sales recently.

PMID: 31799702 [PubMed – as supplied by publisher]


https://www.ncbi.nlm.nih.gov/pubmed/31799702?dopt=Abstract

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/erss.cgi?rss_guid=1BE6Yf6ex8r6DRZaKzQi_iKP-GeW6jP4zTLhuJ2dzIMGHW_IGQ
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Vasodilatory effects of cannabidiol in human pulmonary and rat small mesenteric arteries: modification by hypertension and the potential pharmacological opportunities.

Vasodilatory effects of cannabidiol in human pulmonary and rat small mesenteric arteries: modification by hypertension and the potential pharmacological opportunities.

Related Articles

Vasodilatory effects of cannabidiol in human pulmonary and rat small mesenteric arteries: modification by hypertension and the potential pharmacological opportunities.

J Hypertens. 2019 Dec 02;:

Authors: Baranowska-Kuczko M, Kozłowska H, Kloza M, Sadowska O, Kozłowski M, Kusaczuk M, Kasacka I, Malinowska B

Abstract
OBJECTIVE: Cannabidiol (CBD) has been suggested as a potential antihypertensive drug. The aim of our study was to investigate its vasodilatory effect in isolated human pulmonary arteries (hPAs) and rat small mesenteric arteries (sMAs).
METHODS: Vascular effects of CBD were examined in hPAs obtained from patients during resection of lung carcinoma and sMAs isolated from spontaneously hypertensive (SHR); 11-deoxycorticosterone acetate (DOCA-salt) hypertensive rats or their appropriate normotensive controls using organ bath and wire myography, respectively.
RESULTS: CBD induced almost full concentration-dependent vasorelaxation in hPAs and rat sMAs. In hPAs, it was insensitive to antagonists of CB1 (AM251) and CB2 (AM630) receptors but it was reduced by endothelium denudation, cyclooxygenase inhibitors (indomethacin and nimesulide), antagonists of prostanoid EP4 (L161982), IP (Cay10441), vanilloid TRPV1 (capsazepine) receptors and was less potent under KCl-induced tone and calcium-activated potassium channel (KCa) inhibitors (iberiotoxin, UCL1684 and TRAM-34) and in hypertensive, overweight and hypercholesteremic patients. The time-dependent effect of CBD was sensitive to the PPARγ receptor antagonist GW9662. In rats, the CBD potency was enhanced in DOCA-salt and attenuated in SHR. The CBD-induced relaxation was inhibited in SHR and DOCA-salt by AM251 and only in DOCA-salt by AM630 and endothelium denudation.
CONCLUSION: The CBD-induced relaxation in hPAs that was reduced in hypertensive, obese and hypercholesteremic patients was endothelium-dependent and mediated via KCa and IP, EP4, TRPV1 receptors. The CBD effect in rats was CB1-sensitive and dependent on the hypertension model. Thus, modification of CBD-mediated responses in disease should be considered when CBD is used for therapeutic purposes.

PMID: 31800399 [PubMed – as supplied by publisher]


https://www.ncbi.nlm.nih.gov/pubmed/31800399?dopt=Abstract

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An Open-Label Pilot Study Testing the Feasibility of Assessing Total Symptom Burden in Trials of Cannabinoid Medications in Palliative Care.

An Open-Label Pilot Study Testing the Feasibility of Assessing Total Symptom Burden in Trials of Cannabinoid Medications in Palliative Care.

Related Articles

An Open-Label Pilot Study Testing the Feasibility of Assessing Total Symptom Burden in Trials of Cannabinoid Medications in Palliative Care.

J Palliat Med. 2019 Dec 03;:

Authors: Good PD, Greer RM, Huggett GE, Hardy JR

Abstract
Background: There is considerable interest in the use of cannabinoids for symptom control in palliative care, but there is little high-quality evidence to guide clinical practice. Objectives: Assess the feasibility of using global symptom burden measures to assess response to medicinal cannabis, to determine median tolerated doses of cannabidiol (CBD) and tetrahydrocannabinol (THC), and to document adverse events (AEs). Design: Prospective two-arm open-label pilot trial of escalating doses of CBD and THC oil. Setting/Subjects: Participants had advanced cancer and cancer-related symptoms in a palliative and supportive care service in an Australian cancer center. Measurements: The main outcome measures were the number of participants screened and randomized over the time frame, the number of participants completing days 14 and 28 and providing total symptom distress scores (TSDSs) (measured using the Edmonton Symptom Assessment Scale), and the change from baseline of the TSDS at day 14. Results: Of the 21 participants enrolled (CBD, n = 16; THC, n = 5), 18 (86%) completed the primary outcome measure at day 14 and 8 completed at day 28. The median maximum tolerated doses were CBD, 300 mg/day (range 100-600 mg); THC, 10 mg/day (range 5-30 mg). Nine of 21 patients (43%) met the definition of response (≥6 point reduction in TSDS). Drowsiness was the most common AE. Conclusions: Trials of medicinal cannabis in advanced cancer patients undergoing palliative care are feasible. The doses of THC and CBD used in this study were generally well tolerated and the outcome measure of total symptom distress is promising as a measure of overall symptom benefit. Trial registration: ACTRN12618001205224.

PMID: 31800354 [PubMed – as supplied by publisher]


https://www.ncbi.nlm.nih.gov/pubmed/31800354?dopt=Abstract

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/erss.cgi?rss_guid=1BE6Yf6ex8r6DRZaKzQi_iKP-GeW6jP4zTLhuJ2dzIMGHW_IGQ
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Which Hemp and CBD Trademarks Can be Registered?

Which Hemp and CBD Trademarks Can be Registered?
The Trademark Office made it clear that, (subject to a significant exception,) it will register trademarks for hemp and certain cannabidiol (CBD) products …

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Proposed Rules for Industrial Hemp Published by FDACS Copy

Proposed Rules for Industrial Hemp Published by FDACS Copy
September 24, 2019 – Last week, The Florida Department of Agriculture and Consumer Services (FDACS), published proposed rules regulating …

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High Stakes: Carthage Tobacco Farm Family Invests In Hemp

High Stakes: Carthage Tobacco Farm Family Invests In Hemp
These days, this fifth-generation tobacco farmer and his brothers oversee what may be the largest family-owned hemp operation in North Carolina.

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An Iowa woman was arrested after allegedly selling CBD gummies to the cops. Now, other …

An Iowa woman was arrested after allegedly selling CBD gummies to the cops. Now, other …
An Ankeny business owner was arrested Wednesday for allegedly selling products containing cannabidiol, or CBD, while unlicensed by the state …

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Three steps to becoming a Missouri hemp producer, department announces

Three steps to becoming a Missouri hemp producer, department announces
Since the federal legalization of industrial hemp growth for research purposes in 2014, hemp farmers in Missouri have seen many changes to state …

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Hemp Cannabutter

Hemp Cannabutter
Hemp Cannabutter Adapted from edible Seattle. Hemp-infused oil is the starting point for CBD cookery; it's commonly made from “trim,” which includes …

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Arizona state senator tackles hemp regulations

Arizona state senator tackles hemp regulations
Sonny Borrelli, R-Lake Havasu City, wants to enact a state law that would strip cities and counties of any right to regulate an “industrial hemp site.

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Easing hemp banking guidelines

Easing hemp banking guidelines
MADISON (WKOW) — Financial institutions will no longer have to take extra steps in order to accept customers involved in the hemp industry. Federal …

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Texas: Industrial Hemp Seminar, Lubbock, Dec. 19

Texas: Industrial Hemp Seminar, Lubbock, Dec. 19
Texas producers and those interested in industrial hemp production can attend a “First Things” meeting to learn about potential opportunities and …

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Several hemp votes could flip from yes to no in Black Hills

Several hemp votes could flip from yes to no in Black Hills
The hemp legalization bill passed the House and Senate last winter but was vetoed by Noem. The House voted to override the veto, and Solano voted …

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It's time to clear up CBD misconceptions

It's time to clear up CBD misconceptions
Colorado became the first state to legalize hemp production and CBD five years ago. Both the growing of hemp and CBD must follow strict guidelines.

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Editorial: As the CBD craze grows, doctors and FDA say there's good reason for caution

Editorial: As the CBD craze grows, doctors and FDA say there's good reason for caution
For most of us, this oil extracted from marijuana's ugly cousin, the hemp plant, is more a curiosity than anything else. For doctors like Griffith, it's an …

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Federal Agencies Provide New Guidance for Hemp Banking

Federal Agencies Provide New Guidance for Hemp Banking
The tides have been rapidly changing for hemp companies to gain access to banking, which has not traditionally been available to hemp companies …

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Elev8 Hemp, LLC

Elev8 Hemp, LLC
Join the team at Elev8 Hemp, LLC. Check out the latest job openings, salaries, office locations, remote jobs and company culture insights. Discover …

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New York CBD retailer who received hemp shipment still facing marijuana charges

New York CBD retailer who received hemp shipment still facing marijuana charges
A CBD retailer is worried his store could go out of business after the New York Police Department intercepted its most recent shipment of hemp, …

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Feds join city, state in investigating Jeannette hemp-drying business

Feds join city, state in investigating Jeannette hemp-drying business
3 minutes ago. The U.S. Department of Labor is investigating a controversial hemp-drying facility in Jeannette after employees complained they hadn't …

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SipCozy Launches One Of The World's First Alcohol-Removed, Hemp-Infused Rosé Wines

SipCozy Launches One Of The World's First Alcohol-Removed, Hemp-Infused Rosé Wines
JACKSONVILLE, Fla., Dec. 5, 2019 /PRNewswire/ — SipCozy, a new infused beverage developed by and for women, announced today the launch of …

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Relevium launches organic hemp products in US

Relevium launches organic hemp products in US
Canadian hemp producer Relevium Technologies has launched a line of organic products in the US market under the LeefyLyfe brand name.

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22nd Century Enters CBD Space With $24M Investment In Panacea

22nd Century Enters CBD Space With $24M Investment In Panacea
“Our objective is to build a leading, profitable business in the fast-growing, emerging, legal hemp/cannabis space, and Panacea is a rapidly-growing, …

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Colorado firm Straight Hemp joins growing list of certified companies

Colorado firm Straight Hemp joins growing list of certified companies
CEO Devin Alvarez has a background in hemp cultivation and formerly worked in the medical marijuana industry. He said he has noticed quality …

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HEMP Demo: Intro and Setup – NetDevOps Series, Part 10

HEMP Demo: Intro and Setup – NetDevOps Series, Part 10
See how you can use APIs to build more business-relevant solutions that provide the required consistency and reliability all along the network.

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Hemp Businesses Need Clarity On Credit Card Processing, GOP Congressman Tells Federal …

Hemp Businesses Need Clarity On Credit Card Processing, GOP Congressman Tells Federal …
One day after federal financial regulators issued guidance relaxing requirements for banks doing business with hemp companies, Rep. Andy Barr …

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Meet The New, Shopify-Powered, B2B Online CBD Ordering Platform

Meet The New, Shopify-Powered, B2B Online CBD Ordering Platform
Global Cannabinoids, a bulk and wholesale supplier of U.S. hemp-derived cannabinoids, has officially opened its new online store powered by …

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Hemp Contracts Crucial as Litigation Jumps

Hemp Contracts Crucial as Litigation Jumps
Take the hemp money and run. Expect litigation to rise as the 2019 hemp crop comes in during the first harvest since legal hurdles were lowered in the …

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A Look into the World of Cannabis & Hemp

A Look into the World of Cannabis & Hemp
Excited to learn about medical marijuana , CBD, and hemp? Curious about the medical applications and regulatory environment surrounding …

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Vitafusion Debuts CBD Gummies Featuring Full-Spectrum Hemp Extract

Vitafusion Debuts CBD Gummies Featuring Full-Spectrum Hemp Extract
Gummy vitamin brand Vitafusion has added gummies made with CBD from full-spectrum hemp extract to its product line.

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USMJ Now Offering Azure Hemp And Aloe Revitalizing Serums For Face And Eyes

USMJ Now Offering Azure Hemp And Aloe Revitalizing Serums For Face And Eyes
Yesterday, USMJ introduced all-natural, Non-GMO hulled hemp seeds. The company plans to regularly feature new products throughout December.

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Editorial: USDA should rework its hemp testing rules

Editorial: USDA should rework its hemp testing rules
Farmers have been poring over the details of the U.S. Department of Agriculture's interim rules governing the production of hemp. They haven't liked a …

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December 5, 2019 2:26 pm
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Ask Our Experts: How Prevalent Is Hemp Crop Theft?

Ask Our Experts: How Prevalent Is Hemp Crop Theft?
By New Frontier Data. Q: I keep seeing stories in the news about hemp farmers having their crop stolen by people mistaking it for cannabis; is it really …

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December 5, 2019 1:52 pm
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Marketplace Exchanges Offer Hemp Farmers Harvest-Saving Opportunities

Marketplace Exchanges Offer Hemp Farmers Harvest-Saving Opportunities
By William Sumner, Hemp Business Journal. Passage of the 2018 Farm Bill and the rise of CBD as a nutritional supplement has led to a boom in …

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December 5, 2019 1:52 pm
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Shifting Regulations Open New Doors for the CBD Industry

Shifting Regulations Open New Doors for the CBD Industry
NEW YORK, Dec. 5, 2019 /PRNewswire/ — The U.S. cannabidiol market burgeoned after the passage of the Farm Bill in 2018. The Farm Bill legalized …

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December 5, 2019 1:52 pm
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FDA Stresses CBD Safety Concerns in 15 Warning Letters and Revised Consumer Update

FDA Stresses CBD Safety Concerns in 15 Warning Letters and Revised Consumer Update
By Tonya M. Esposito and Renee B. Appel Seyfarth Synopsis: In its largest mass enforcement action involving cannabidiol (CBD) yet, the U.S. Food &

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December 5, 2019 12:52 pm
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Industrial Hemp Study Committee Finishes Interim Work With Draft Legislation

Industrial Hemp Study Committee Finishes Interim Work With Draft Legislation
(WNAX) — The interim Industrial Hemp Committee of the South Dakota legislature wrapped up their work by passing a draft bill that would allow …

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December 5, 2019 11:30 am
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Maine and hemp producers say new federal rules could hurt industry's growth

Maine and hemp producers say new federal rules could hurt industry's growth
AUGUSTA, Maine (AP) — Players in Maine's hemp farming industry — including the agriculture department — say recent changes to federal rules …

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December 5, 2019 10:41 am
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Boutique CBD store opens in Park Slope

Boutique CBD store opens in Park Slope
A up-scale new CBD store has opened on Park Slope's Fifth Avenue, offering hemp-based products along with a crash course on the basics of the …

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December 5, 2019 9:45 am
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AgTech Scientific

AgTech Scientific
AgTech Scientific is a mass market ingredient provider specializing in hemp derived compounds. We are on a mission to bring our hemp derived …

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December 5, 2019 9:29 am
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Outside Sets Eco Hat $29.95

Outside Sets Eco Hat $29.95
The Eco-friendly Outside Sets hat comes unstructured with a hemp blend. Featuring a Smart Fit with an adjustable slide back closure, the earth thanks …

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December 5, 2019 9:06 am
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THE HEMP GARDENERS

THE HEMP GARDENERS
CBD Hemp Softgel, Golden-filtered but preserving essential Cannabinoids in the process. These capsules are made from Co2 extracted Premium …

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December 5, 2019 8:17 am
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CBD + Hemp

CBD + Hemp
Cannabis has rapidly evolved from taboo topic to mainstream fixture in what seems like a matter of months. The truth? It's because the CBD and hemp …

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December 5, 2019 8:06 am
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Columbia Basin Bioscience Opens Massive CBD Production Facility

Columbia Basin Bioscience Opens Massive CBD Production Facility
Columbia Basin Bioscience (CBB) has opened a vertically integrated, single-site cannabidiol (CBD) production facility. The company was created to …

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December 5, 2019 7:09 am
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Mary's Brands Introduces Signature Hemp-Based Facial And Massage

Mary's Brands Introduces Signature Hemp-Based Facial And Massage
The massage and facial integrate the power of Mary's Brands CBD-rich whole-plant hemp extracts.

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December 5, 2019 6:35 am
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CBD, hemp store to open in Sylvester

CBD, hemp store to open in Sylvester
“People think that hemp is like a high, that it's gonna get you high and it's gonna get you crazy and it's not that. All hemp does is soothes you and takes …

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December 5, 2019 4:30 am
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Chatham hemp farmer targeted again by thieves seeking marijuana

Chatham hemp farmer targeted again by thieves seeking marijuana
By Bryan Mims, WRAL reporter. Siler City, N.C. — A Chatham County hemp grower says he has stepped up security on his property because he has …

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December 5, 2019 4:18 am
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How Do I Grow Hemp in Ohio?

How Do I Grow Hemp in Ohio?
Ohio, with the passage of Senate Bill 57, legalized hemp and CBD products. Now, Ohio must devise a regulatory framework for hemp cultivation and …

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December 5, 2019 4:11 am
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Hemp Co. Sues French Exec Over Farm Equipment Deal

Hemp Co. Sues French Exec Over Farm Equipment Deal
"Plaintiff knows of other suppliers and laborers who performed work for the defendants in Minnesota for defendants hemp harvest and in spite of the …

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December 5, 2019 3:33 am
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Police charge Ankeny woman with illegally selling CBD

Police charge Ankeny woman with illegally selling CBD
Authorities arrested a woman in Ankeny Wednesday for allegedly selling illegal cannabidiol. Authorities booked 33-year-old Lacey Navin into Polk …

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December 5, 2019 3:22 am
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New regulations address banking discrimination against hemp farmers

New regulations address banking discrimination against hemp farmers
Washington, D.C. — Local hemp farmers and growers may soon face fewer obstacles when it comes to banking. Federal and state financial …

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December 5, 2019 2:26 am
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Bank Regulators Get into the Weeds About Industrial Hemp

Bank Regulators Get into the Weeds About Industrial Hemp
Business Marijuana Hemp Leaves Cannabis Stock Exchange Market … information to financial institutions banking hemp-related business customers.

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December 5, 2019 2:24 am
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420 Valley announces plans for hemp production facility in Las Cruces

420 Valley announces plans for hemp production facility in Las Cruces
Alicia Keyes, Cabinet Secretary of New Mexico Economic Development speaks at the announcement of 420 Valley, LLC business in Las Cruces on …

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December 5, 2019 2:03 am
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Hemp facility in Sidney is taking a whole plant approach

Hemp facility in Sidney is taking a whole plant approach
SIDNEY — The new hemp plant that's opened up in Sidney, Montana, isn't worried about the legal status of CBD oil. That's because the company is …

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December 5, 2019 1:30 am
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Las Cruces invests in hemp manufacturing firm to be located on Valley Drive

Las Cruces invests in hemp manufacturing firm to be located on Valley Drive
LAS CRUCES, NM (KFOX14/CBS4) — The City of Las Cruces is investing $150,000, along with the state investing $400,000, into a new facility called …

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December 5, 2019 12:33 am
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Missouri Industrial Hemp Program establishes path forward for 2020 growing season

Missouri Industrial Hemp Program establishes path forward for 2020 growing season
4, the Missouri Department of Agriculture announced the process for farmers to apply for a registration to grow industrial hemp in Missouri during the …

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December 5, 2019 12:33 am
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The CBD Products That Trainers Recommend (and Use Themselves) For Workout Recovery

The CBD Products That Trainers Recommend (and Use Themselves) For Workout Recovery
Gone shopping lately? It seems like cannabidiol, or CBD, is in everything. One POPSUGAR contributor likes to describe it as "Mother Nature's Xanax …

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December 5, 2019 12:00 am
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NY prosecutors stall on dropping hemp charges, angering business owners

NY prosecutors stall on dropping hemp charges, angering business owners
Ronen Levy was arrested while attempting to pick up a 106-pound shipment of hemp from Fox Holler Farms in New Haven, Vermont. Levy's brother …

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December 4, 2019 11:48 pm
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Congressman Barr Commends Financial Regulators on Hemp Guidance, Urges Additional …

Congressman Barr Commends Financial Regulators on Hemp Guidance, Urges Additional …
WASHINGTON, D.C. – Yesterday, the Federal Deposit Insurance Corporation (FDIC), Office of the Comptroller of the Currency (OCC), the Federal …

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December 4, 2019 11:38 pm
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CBD Wellness in AZ

CBD Wellness in AZ
I am a Brand Representative for the leading Hemp Based CBD company in the world. Our products are triple tested and Pharmaceutical Grade .

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December 4, 2019 11:29 pm
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Neighbors raise stink over proposed hemp, pot facility

Neighbors raise stink over proposed hemp, pot facility
(KOIN) — People living in Newberg and the Chehalem Mountains area are pushing back against a proposed marijuana and hemp processing facility …

https://www.google.com/url?rct=j&sa=t&url=https://www.koin.com/news/special-reports/neighbors-raise-stink-over-proposed-hemp-pot-facility/&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNFx2vMWGtkReqo0FIs3SeShpx4EkQ
December 4, 2019 11:26 pm
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Skyrocketing hemp production in Kentucky leaves industry excited, but cautious

Skyrocketing hemp production in Kentucky leaves industry excited, but cautious
The Kentucky Department of Agriculture has seen a huge increase in hemp production, and people from across the commonwealth are getting in on it.

https://www.google.com/url?rct=j&sa=t&url=https://www.wave3.com/2019/12/04/skyrocketing-hemp-production-kentucky-leaves-industry-excited-cautious/&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNGp8vi0bFCJwi7O2h6jT2goarC1Yg
December 4, 2019 10:18 pm
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Bennet Welcomes New Banking Guidelines for Hemp Farmers and Processors

Bennet Welcomes New Banking Guidelines for Hemp Farmers and Processors
Washington, D.C. – Today, Colorado U.S. Senator Michael Bennet welcomed new guidance from federal financial regulators that would help hemp …

https://www.google.com/url?rct=j&sa=t&url=https://www.bennet.senate.gov/public/index.cfm/2019/12/bennet-welcomes-new-banking-guidelines-for-hemp-farmers-and-processors&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNHkyoKaF83K7N5enqBToFVlATmdfA
December 4, 2019 9:49 pm
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FDA Claims CBD Is Evil, While WHO And NIDA Said It's All Good

FDA Claims CBD Is Evil, While WHO And NIDA Said It's All Good
There is something fishy going on in the United States concerning the government's negative stance on CBD (cannabidiol). The scientific goons over …

https://www.google.com/url?rct=j&sa=t&url=https://www.forbes.com/sites/mikeadams/2019/12/04/fda-claims-cbd-is-evil-while-who-and-nida-says-its-all-good/&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNEBJ4g_gZh3v1kgDSoWun0HFBWVkA
December 4, 2019 9:22 pm
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New federal hemp rules would hurt Maine's fledgling industry, official says

New federal hemp rules would hurt Maine's fledgling industry, official says
AUGUSTA — State agriculture officials are saying new federal rules regulating hemp production nationally would hurt Maine's rapidly growing hemp …

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December 4, 2019 8:54 pm
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SC hemp farmer arrested by SLED wins initial victory in court allowing him to sell crop

SC hemp farmer arrested by SLED wins initial victory in court allowing him to sell crop
A Dorchester County hemp farmer who was arrested by law enforcement earlier this year after they destroyed his crops has won an initial victory in …

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December 4, 2019 8:37 pm
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Reduce embodied carbon with hemp insulation batts from NatureFibres

Reduce embodied carbon with hemp insulation batts from NatureFibres
I think they should rename the town Le Chanvre, French for hemp. Like asbestos, it is a locally made insulating product, however the hemp insulation …

https://www.google.com/url?rct=j&sa=t&url=https://www.treehugger.com/sustainable-product-design/reduce-embodied-carbon-hemp-insulation-batts-naturefibres.html&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNFy42GhuDSCl27cVZFqOb7NIhMznQ
December 4, 2019 8:26 pm
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Tennessee CBD & Hemp Trade Show

Tennessee CBD & Hemp Trade Show
Come learn about the new world of CBD/Hemp Products. Our trade shows will have over 100 vendors showcasing their new products and services.

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December 4, 2019 8:16 pm
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Embattled Pennsylvania hemp processor ordered to close

Embattled Pennsylvania hemp processor ordered to close
A hemp drying and processing company in Pennsylvania that has received numerous complaints about its facilities, odor and lack of pay to employees …

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December 4, 2019 8:03 pm
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The Indian Hemp Drugs Commission 1893-1894.

The Indian Hemp Drugs Commission 1893-1894.

Related Articles

The Indian Hemp Drugs Commission 1893-1894.

Addiction. 2019 Sep;114(9):1679-1682

Authors: Hall W

PMID: 31788878 [PubMed – in process]


https://www.ncbi.nlm.nih.gov/pubmed/31788878?dopt=Abstract

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/erss.cgi?rss_guid=12OY-2YuXEtecDR7WE-A2c-rtPCJqs0e275YvMbwhvRR34bgib
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The Bee Community of Cannabis sativa and Corresponding Effects of Landscape Composition.

The Bee Community of Cannabis sativa and Corresponding Effects of Landscape Composition.

Related Articles

The Bee Community of Cannabis sativa and Corresponding Effects of Landscape Composition.

Environ Entomol. 2019 Dec 02;:

Authors: Flicker NR, Poveda K, Grab H

Abstract
Industrial hemp, Cannabis sativa (Cannabaceae), is a newly introduced and rapidly expanding crop in the American agricultural landscape. As an exclusively wind-pollinated crop, hemp lacks nectar but produces an abundance of pollen during a period of floral dearth in agricultural landscapes. These pollen resources are attractive to a range of bee species but the diversity of floral visitors and their use of hemp across a range of agricultural contexts remains unclear. We made repeated sweep net collections of bees visiting hemp flowers on farms in New York, which varied in both landscape context and phenotypic traits of hemp varieties. We identified all bee visitors to the species level and found that hemp supported 16 different bee species. Landscape simplification negatively impacted the abundance of bees visiting hemp flowers but did not affect the species richness of the community. Plant height, on the other hand, was strongly correlated with bee species richness and abundance for hemp plots with taller varieties attracting a broader diversity of bee species. Because of its temporally unique flowering phenology, hemp has the potential to provide a critical nutritional resource to a diverse community of bees during a period of floral scarcity and thereby may help to sustain agroecosystem-wide pollination services for other crops in the landscape. As cultivation of hemp increases, growers, land managers, and policy makers should consider its value in supporting bee communities and take its attractiveness to bees into account when developing pest management strategies.

PMID: 31789341 [PubMed – as supplied by publisher]


https://www.ncbi.nlm.nih.gov/pubmed/31789341?dopt=Abstract

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/erss.cgi?rss_guid=12OY-2YuXEtecDR7WE-A2c-rtPCJqs0e275YvMbwhvRR34bgib
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How to Find the Best Quality CBD Oil For Pain

How to Find the Best Quality CBD Oil For Pain
Cannabidiol is from the cannabis plant that's extracted for medicinal purposes. It's commonly extracted from agricultural hemp, which makes it …

https://www.google.com/url?rct=j&sa=t&url=https://www.clnsmedia.com/find-best-quality-cbd-oil-pain/&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNHdZizYjCIeHet9-Rf5EIkCrcak7A
December 4, 2019 7:52 pm
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Anxiolytic Effects of Repeated Cannabidiol Treatment in Teenagers With Social Anxiety Disorders.

Anxiolytic Effects of Repeated Cannabidiol Treatment in Teenagers With Social Anxiety Disorders.

Related Articles

Anxiolytic Effects of Repeated Cannabidiol Treatment in Teenagers With Social Anxiety Disorders.

Front Psychol. 2019;10:2466

Authors: Masataka N

Abstract
Accumulated evidence indicates that cannabidiol (CBD), a nonpsychotomimetic and nonaddictive main component of the Cannabis sativa plant, reverses anxiety-like behavior. The purpose of the present study was to assess the efficacy of CBD treatment for Japanese late teenagers with social anxiety disorder (SAD). Thirty-seven 18-19-year-old Japanese teenagers with SAD and avoidant personality disorder received, in a double-blind study, cannabis oil (n = 17) containing 300 mg CBD or placebo (n = 20) daily for 4 weeks. SAD symptoms were measured at the beginning and end of the treatment period using the Fear of Negative Evaluation Questionnaire and the Liebowitz Social Anxiety Scale. CBD significantly decreased anxiety measured by both scales. The results indicate that CBD could be a useful option to treat social anxiety.

PMID: 31787910 [PubMed]


https://www.ncbi.nlm.nih.gov/pubmed/31787910?dopt=Abstract

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/erss.cgi?rss_guid=1BE6Yf6ex8r6DRZaKzQi_iKP-GeW6jP4zTLhuJ2dzIMGHW_IGQ
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The Effectiveness of Topical Cannabidiol Oil in Symptomatic Relief of Peripheral Neuropathy of the Lower Extremities.

The Effectiveness of Topical Cannabidiol Oil in Symptomatic Relief of Peripheral Neuropathy of the Lower Extremities.

Related Articles

The Effectiveness of Topical Cannabidiol Oil in Symptomatic Relief of Peripheral Neuropathy of the Lower Extremities.

Curr Pharm Biotechnol. 2019 Dec 01;:

Authors: Xu DH, Cullen BD, Tang M, Fang Y

Abstract
BACKGROUND: Peripheral neuropathy can significantly impact the quality of life for those who are affected, as therapies from the current treatment algorithm often fail to deliver adequate symptom relief. There has, however, been an increasing body of evidence for the use of cannabinoids in the treatment of chronic, noncancer pain. The efficacy of a topically delivered cannabidiol (CBD) oil in the management of neuropathic pain was examined in this four-week, randomized and placebo-controlled trial.
METHODS: In total 29 patients with symptomatic peripheral neuropathy were recruited and enrolled. 15 patients were randomized to the CBD group with the treatment product containing 250 mg CBD/3 fl. oz, and 14 patients were randomized to the placebo group. After four weeks, the placebo group was allowed to crossover into the treatment group. The neuropathic pain scale (NPS) was administered biweekly to assess the mean change from baseline to the end of the treatment period.
RESULTS: The study population included 62.1% males and 37.9% females with a mean age of 68 years. There was a statistically significant reduction in intense pain, sharp pain, cold and itchy sensations in the CBD group when compared to the placebo group. No adverse events were reported in this study.
CONCLUSIONS: Our findings demonstrate that the transdermal application of CBD oil can achieve significant improvement in pain and other disturbing sensations in patients with peripheral neuropathy. The treatment product was well tolerated and may provide a more effective alternative compared to other current therapies in the treatment of peripheral neuropathy.

PMID: 31793418 [PubMed – as supplied by publisher]


https://www.ncbi.nlm.nih.gov/pubmed/31793418?dopt=Abstract

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/erss.cgi?rss_guid=1BE6Yf6ex8r6DRZaKzQi_iKP-GeW6jP4zTLhuJ2dzIMGHW_IGQ
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Opposite Effects of Neuroprotective Cannabinoids, Palmitoylethanolamide, and 2-Arachidonoylglycerol on Function and Morphology of Microglia.

Opposite Effects of Neuroprotective Cannabinoids, Palmitoylethanolamide, and 2-Arachidonoylglycerol on Function and Morphology of Microglia.

Related Articles

Opposite Effects of Neuroprotective Cannabinoids, Palmitoylethanolamide, and 2-Arachidonoylglycerol on Function and Morphology of Microglia.

Front Neurosci. 2019;13:1180

Authors: Hohmann U, Pelzer M, Kleine J, Hohmann T, Ghadban C, Dehghani F

Abstract
Various studies performed in cultured cells and in in vivo models of neuronal damage showed that cannabinoids exert a neuroprotective effect. The increase in cannabinoids and cannabinoid like substances after stroke has been postulated to limit the content of neuronal injury. As well-accepted, inflammation, and neuronal damage are coupled processes and microglial cells as the main intrinsic immunological effector within the brain play a central role in their regulation. Treatment with the endocannabinoid, 2-arachidonoylglycerol (2-AG) or the endocannabinoid-like substance, palmitoylethanolamide (PEA) affected microglial cells and led to a decrease in the number of damaged neurons after excitotoxical lesion in organotypic hippocampal slice cultures (OHSC). 2-AG activated abnormal cannabidiol (abn-CBD) receptor, PEA was shown to mediate neuroprotection via peroxisome proliferator-activated receptor (PPAR)α. Despite the known neuroprotective and anti-inflammatory properties, the potential synergistic effect, namely possible entourage effect after treatment with the combination of these two protective cannabinoids has not been examined yet. After excitotoxical lesion OHSC were treated with PEA, 2-AG or a combination of both and the number of damaged neurons was evaluated. To investigate the role of microglial cells in PEA and 2-AG mediated protection, primary microglial cell cultures were treated with lipopolysaccharide (LPS) and 2-AG, PEA or a combination of those. Thereafter, we measured NO production, ramification index, proliferation and PPARα distribution in microglial cells. While PEA or 2-AG alone were neuroprotective, their co-application vanished the protective effect. This behavior was independent of microglial cells. Furthermore, PEA and 2-AG had contrary effects on ramification index and on NO production. No significant changes were observed in the proliferation rate of microglial cells after treatment. The expression of PPARα was not changed upon stimulation with PEA or 2-AG, but the distribution was significantly altered. 2-AG and PEA mediated neuroprotection was abolished when co-applied. Both cannabinoids exert contrary effects on morphology and function of microglial cells. Co-application of both cannabinoids with different targets did not lead to a positive additive effect as expected, presumably due to the contrary polarization of microglial cells.

PMID: 31787870 [PubMed]


https://www.ncbi.nlm.nih.gov/pubmed/31787870?dopt=Abstract

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/erss.cgi?rss_guid=1BE6Yf6ex8r6DRZaKzQi_iKP-GeW6jP4zTLhuJ2dzIMGHW_IGQ
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Hemp and CBD

Hemp and CBD
The hemp industry is up in arms over the USDA's interim rules establishing a domestic hemp program. As of this writing you can find some 900 …

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December 4, 2019 6:56 pm
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Hemp Naturals, Inc. Leading Construction Industry Hemp Revolution

Hemp Naturals, Inc. Leading Construction Industry Hemp Revolution
Hemp-focused, development-forward research and construction industry firm Hemp Naturals, Inc. looks set to flourish thanks to latest U.S. agricultural …

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December 4, 2019 6:23 pm
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Considering CBD oil for your pets? Here's what you need to know

Considering CBD oil for your pets? Here's what you need to know
CBD oil is great for pets in the sense that they get the same aches and pains that we do,” said Teisha Connor of Hemp XR in Greensboro, where you …

https://www.google.com/url?rct=j&sa=t&url=https://myfox8.com/2019/12/04/considering-cbd-oil-for-your-pets-heres-what-you-need-to-know/&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNECQJLPi_lEMl8BNxECuVGldhYKrw
December 4, 2019 5:48 pm
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Church & Dwight's Vitafusion enters CBD space

Church & Dwight's Vitafusion enters CBD space
Vitafusion just announced they have added CBD gummies to their line-up of vitamins. The new line of offerings feature CBD from full spectrum hemp …

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December 4, 2019 5:48 pm
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