CannaSearch Breaking News on CBD + Hemp

Guidance Procedures 2.0 for the US Hemp Authority™Certification Program Released Today!

Guidance Procedures 2.0 for the US Hemp Authority™Certification Program Released Today!
A Message From The U.S. Hemp Authority: GUIDANCE PROCEDURES 2.

https://www.google.com/url?rct=j&sa=t&url=https://hempsupporter.com/guidance-procedures-2-0-for-the-u-s-hemp-authoritycertification-program-released/&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNEdjQuR-B1LJ2AmnlgJ3suY5_XScQ
November 11, 2019 9:37 pm
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Police: Would-be pot thieves stole hemp

Police: Would-be pot thieves stole hemp
SPRING HOPE — Police recently arrested two men who allegedly thought they had stolen illicit marijuana plants, but instead had unearthed and …

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November 11, 2019 8:17 pm
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Takeaways From the USDA Interim Final Rule on Domestic Hemp Production

Takeaways From the USDA Interim Final Rule on Domestic Hemp Production
The US Department of Agriculture (USDA) has published an interim final rule in the Federal Register1 that implements regulations for hemp …

https://www.google.com/url?rct=j&sa=t&url=https://www.barclaydamon.com/alerts/takeaways-from-the-usda-interim-final-rule-on-domestic-hemp-production&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNGEUZ_b2nmik1Pjey4aeaF7nrp2hQ
November 11, 2019 7:50 pm
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Assembly to take up hemp regulation, Bible Week resolution in Tuesday session

Assembly to take up hemp regulation, Bible Week resolution in Tuesday session
The Assembly is slated to vote on rules to transition the state's pilot hemp program to a permanent one, while also taking up discussion on a resolution …

https://www.google.com/url?rct=j&sa=t&url=https://madison.com/wsj/news/local/govt-and-politics/assembly-to-take-up-hemp-regulation-bible-week-resolution-in/article_ef2d7f57-e834-5da2-8043-51f0dfaab282.html&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNG3tHJNYep1-ewCiX9NEa3ZuHbQuw
November 11, 2019 7:41 pm
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Cannabis: THC vs. CBD Critical Differences

Cannabis: THC vs. CBD Critical Differences
When you look at a cannabis plant and a hemp plant side by side, the plants themselves look identical to an untrained eye, making it a bit challenging …

https://www.google.com/url?rct=j&sa=t&url=https://cpatrendlines.com/2019/11/11/cannabis-thc-vs-cbd-critical-differences/&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNG8miT8deJtrhQAnR8-UTkD7wLDCA
November 11, 2019 7:39 pm
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Medicinal cannabis in Latin America: History, current state of regulation, and the role of the pharmacist in a new clinical experience with cannabidiol oil.

Medicinal cannabis in Latin America: History, current state of regulation, and the role of the pharmacist in a new clinical experience with cannabidiol oil.

Related Articles

Medicinal cannabis in Latin America: History, current state of regulation, and the role of the pharmacist in a new clinical experience with cannabidiol oil.

J Am Pharm Assoc (2003). 2019 Nov 06;:

Authors: Cáceres Guido P, Riva N, Calle G, Dell’Orso M, Gatto M, Sberna N, Schaiquevich P

Abstract
OBJECTIVE: Cannabis sativa was introduced in Latin America in the 16th century. Nevertheless, many years have elapsed, and scientific progress and the medicinal use of C sativa have been restricted by the national laws of the countries in the region.
SUMMARY: In Argentina, the first law on medical cannabis, approved in 2017 (#17,350), establishes a regulatory framework for the medical use and scientific research of this plant and its derivatives. In 2018, the first clinical research protocol in Latin America was approved at Hospital de Pediatria Garrahan (Buenos Aires, Argentina) to evaluate the efficacy and safety of cannabidiol (CBD) oil for the treatment of pediatric patients with refractory epilepsy. In this context, the role of pharmacists in the health care system related to the study protocol and the medicinal use of CBD has evolved from dispensing to active participation in clinical follow-up and research protocols.
CONCLUSION: Considering this experience, here we discuss the active role of the clinical pharmacist in the use of medicinal cannabis. Medicinal cannabis should be controlled in a legal framework based on clinical evidence, and the participation of the pharmacist in research and clinical protocols, as well as the dispensing and provision of information on the medicinal products should be emphasized in the clinical setting.

PMID: 31706799 [PubMed – as supplied by publisher]


https://www.ncbi.nlm.nih.gov/pubmed/31706799?dopt=Abstract

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/erss.cgi?rss_guid=1BE6Yf6ex8r6DRZaKzQi_iKP-GeW6jP4zTLhuJ2dzIMGHW_IGQ
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Antidepressant active ingredients from herbs and nutraceuticals used in TCM: pharmacological mechanisms and prospects for drug discovery.

Antidepressant active ingredients from herbs and nutraceuticals used in TCM: pharmacological mechanisms and prospects for drug discovery.

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Antidepressant active ingredients from herbs and nutraceuticals used in TCM: pharmacological mechanisms and prospects for drug discovery.

Pharmacol Res. 2019 Nov 06;:104520

Authors: Wang YS, Shen CY, Jiang JG

Abstract
Depression is a widespread psychological disorder that affects up to 20% of the world’s population. Traditional Chinese medicine (TCM), with its unique curative effect in depression treatment, is gaining increasing attention as the discovery of novel antidepressant drug has become the pursuit of pharmaceutical. This article summarizes the work done on the natural products from TCM that have been reported to conceive antidepressant effects in the past two decades, which can be classified according to various mechanisms including increasing synaptic concentrations of monoamines, alleviating the hypothalamic-pituitary-adrenal (HPA) axis dysfunctions, lightening the impairment of neuroplasticity, fighting towards immune and inflammatory dysregulation. The antidepressant active ingredients identified can be generally divided into saponins, flavonoids, alkaloids, polysaccharides and others. Albiflorin, Baicalein, Berberine chloride, beta-Asarone, cannabidiol, Curcumin, Daidzein, Echinocystic acid (EA), Emodin, Ferulic acid, Gastrodin, Genistein, Ginsenoside Rb1, Ginsenoside Rg1, Ginsenoside Rg3, Hederagenin, Hesperidin, Honokiol, Hyperoside, Icariin, Isoliquiritin, Kaempferol, Liquiritin, L-theanine, Magnolol, Paeoniflorin, Piperine, Proanthocyanidin, Puerarin, Quercetin, Resveratrol (trans), Rosmarinic acid, Saikosaponin A, Senegenin, Tetrahydroxystilbene glucoside and Vanillic acid are Specified in this review. Simultaneously, chemical structures of the active ingredients with antidepressant activities are listed and their sources, models, efficacy and mechanisms are described. Chinese compound prescription and extracts that exert antidepressant effects are also introduced, which may serve as a source of inspiration for further development. In the view of present study, the antidepressant effect of certain TCMs are affirmative and encouraging. However, there are a lot of work needs to be done to evaluate the exact therapeutic effects and mechanisms of those active ingredients, specifically, to establish a unified standard for diagnosis and evaluation of curative effect.

PMID: 31706012 [PubMed – as supplied by publisher]


https://www.ncbi.nlm.nih.gov/pubmed/31706012?dopt=Abstract

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/erss.cgi?rss_guid=1BE6Yf6ex8r6DRZaKzQi_iKP-GeW6jP4zTLhuJ2dzIMGHW_IGQ
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Cannabidiol increases the nociceptive threshold in a preclinical model of Parkinson's disease.

Cannabidiol increases the nociceptive threshold in a preclinical model of Parkinson's disease.

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Cannabidiol increases the nociceptive threshold in a preclinical model of Parkinson’s disease.

Neuropharmacology. 2019 Nov 07;:107808

Authors: Crivelaro do Nascimento G, Ferrari DP, Guimaraes FS, Del Bel EA, Bortolanza M, Ferreira-Junior NC

Abstract
Medications that improve pain threshold can be useful in the pharmacotherapy of Parkinson’s disease (PD). Pain is a prevalent PD’s non-motor symptom with a higher prevalence of analgesic drugs prescription for patients. However, specific therapy for PD-related pain are not available. Since the endocannabinoid system is expressed extensively in different levels of pain pathway, drugs designed to target this system have promising therapeutic potential in the modulation of pain. Thus, we examined the effects of the 6-hydroxydopamine- induced PD on nociceptive responses of mice and the influence of cannabidiol (CBD) on 6-hydroxydopamine-induced nociception. Further, we investigated the pathway involved in the analgesic effect of the CBD through the co-administration with a fatty acid amide hydrolase (FAAH) inhibitor, increasing the endogenous anandamide levels, and possible targets from anandamide, i.e., the cannabinoid receptors subtype 1 and 2 (CB1 and CB2) and the transient receptor potential vanilloid type 1 (TRPV1). We report that 6-hydroxydopamine- induced parkinsonism decreases the thermal and mechanical nociceptive threshold, whereas CBD (acute and chronic treatment) reduces this hyperalgesia and allodynia evoked by 6-hydroxydopamine. Moreover, ineffective doses of either FAAH inhibitor or TRPV1 receptor antagonist potentialized the CBD-evoked antinociception while an inverse agonist of the CB1 and CB2 receptor prevented the antinociceptive effect of the CBD. Altogether, these results indicate that CBD can be a useful drug to prevent the parkinsonism-induced nociceptive threshold reduction. They also suggest that CB1 and TRPV1 receptors are important for CBD-induced analgesia and that CBD could produce these analgesic effects increasing endogenous anandamide levels.

PMID: 31706993 [PubMed – as supplied by publisher]


https://www.ncbi.nlm.nih.gov/pubmed/31706993?dopt=Abstract

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/erss.cgi?rss_guid=1BE6Yf6ex8r6DRZaKzQi_iKP-GeW6jP4zTLhuJ2dzIMGHW_IGQ
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Mile High Labs Donates CBD Tinctures to Veterans Support and Advocacy Group

Mile High Labs Donates CBD Tinctures to Veterans Support and Advocacy Group
BROOMFIELD, Colo., Nov. 11, 2019 (GLOBE NEWSWIRE) — Mile High Labs, the world's largest processor of hemp-derived CBD, today announced …

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November 11, 2019 7:24 pm
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Colorado CBD Seed Announces Agreement with University of Florida to Donate Feminized Hemp

Colorado CBD Seed Announces Agreement with University of Florida to Donate Feminized Hemp
Colorado CBD Seed, an HM Health LLC company, announces that it has signed an agreement to donate their proprietary Abacus Early Bird feminized …

https://www.google.com/url?rct=j&sa=t&url=https://seedworld.com/colorado-cbd-seed-announces-agreement-with-university-of-florida-to-donate-feminized-hemp-seeds-for-agricultural-hemp-research/&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNGsZ8dNBsk-okEfYMng2JhwFb987A
November 11, 2019 7:02 pm
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Thousand Oaks extends moratorium on new hemp businesses for 10 more months

Thousand Oaks extends moratorium on new hemp businesses for 10 more months
The Thousand Oaks City Council has extended its moratorium on new hemp businesses in town until next September. The council initially banned …

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November 11, 2019 7:01 pm
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Aurora Cannabis' next big play: The US CBD market

Aurora Cannabis' next big play: The US CBD market
Aurora plans to aggressively pursue the United States cannabis market with an acquisition in the hemp-derived CBD space as its likely first big play.

https://www.google.com/url?rct=j&sa=t&url=https://www.nbc-2.com/story/41303133/aurora-cannabis-next-big-play-the-us-cbd-market&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNGGkuGL3_iF27X2HJvUhoYXhJsZjA
November 11, 2019 6:16 pm
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CBD American Shaman Racine Announces Prestigious US Hemp Authority Certification

CBD American Shaman Racine Announces Prestigious US Hemp Authority Certification
CBD American Shaman Racine, 305 Main Street, is proud to announce that it is one of handfull of CBD companies in the nation to acquire US Hemp …

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November 11, 2019 5:42 pm
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NIU's Global Round-up: ESSNA warns of risk of failed drug tests with CBD products, Blackmores …

NIU's Global Round-up: ESSNA warns of risk of failed drug tests with CBD products, Blackmores …
The European Specialist Sports Nutrition Alliance (ESSNA) has warned athletes that using CBD (cannabidiol) products may be at risk of failing …

https://www.google.com/url?rct=j&sa=t&url=https://www.nutraingredients-usa.com/Article/2019/11/11/NIU-s-Global-Round-up-ESSNA-warns-of-risk-of-failed-drug-tests-with-CBD-products-Blackmores-eyes-India-and-more&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNGs-UbtAEhELYMlHsCub_IsQH3v0w
November 11, 2019 5:19 pm
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Neptune, IFF Agree To Co-develop Hemp-derived CBD Products – Quick Facts

Neptune, IFF Agree To Co-develop Hemp-derived CBD Products – Quick Facts
(RTTNews) – Neptune Wellness Solutions Inc. (NEPT) has entered into a collaboration agreement with International Flavors & Fragrances Inc. (IFF) to …

https://www.google.com/url?rct=j&sa=t&url=https://www.nasdaq.com/articles/neptune-iff-agree-to-co-develop-hemp-derived-cbd-products-quick-facts-2019-11-11&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNFVz6lbGB6bVDfvjJhMkGVD3htxbg
November 11, 2019 11:44 am
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Neptune Announces a Definitive Agreement with International Flavors & Fragrances to Co-Develop …

Neptune Announces a Definitive Agreement with International Flavors & Fragrances to Co-Develop …
This partnership will accelerate Neptune's vision and growth strategy to be the leading producer of hemp extracts ingredients and finished products for …

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November 11, 2019 11:06 am
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Hemp license applications, registration open for 2020 season

Hemp license applications, registration open for 2020 season
Hemp licensing applications and registrations are available for the 2020 Wisconsin growing season, as of Nov. 1. The deadline for current licensees to …

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November 11, 2019 11:04 am
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Neenah Packaging Jumps on the CBD Bandwagon with New Hemp Fiber Folding Board

Neenah Packaging Jumps on the CBD Bandwagon with New Hemp Fiber Folding Board
Neenah Packaging recently introduced a new line of hemp fiber folding board to address unique packaging needs in the exploding CBD market.

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November 11, 2019 11:02 am
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More highs for hemp: Premium CBD-infused beverage brand expands range

More highs for hemp: Premium CBD-infused beverage brand expands range
11 Nov 2019 — US-based premium CBD-infused beverage brand Good Day has launched two new SKUs; Chamomile Herbal Tea and Citrus …

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November 11, 2019 8:55 am
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GW Pharmaceuticals Receives Positive NICE Recommendation for EPIDYOLEX (Cannabidiol)

GW Pharmaceuticals Receives Positive NICE Recommendation for EPIDYOLEX (Cannabidiol)
Cannabidiol oral solution is recommended as an adjunctive therapy for seizures associated with Lennox Gastaut syndrome (LGS) or Dravet syndrome …

https://www.google.com/url?rct=j&sa=t&url=https://www.technologynetworks.com/tn/news/gw-pharmaceuticals-receives-positive-nice-recommendation-for-epidyolex-cannabidiol-327046&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNGc61XMsPGG238Rr3CT1_-siONmzg
November 11, 2019 8:22 am
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MDA schedules listening sessions on industrial hemp

MDA schedules listening sessions on industrial hemp
Minnesota is drafting a state hemp regulation plan to submit to USDA.

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November 11, 2019 8:06 am
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Oregon hemp operation fined $825K

Oregon hemp operation fined $825K
State labor regulators have fined the owners of a hemp processing operation in Southern Oregon $825,000 for housing and employing two dozen …

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November 11, 2019 7:39 am
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USDA announces establishment of US Domestic Hemp Production Program

USDA announces establishment of US Domestic Hemp Production Program
By Dave Russell, Ohio Ag Net. The interim final rule formalizing the U.S. Domestic Hemp Production Program was published in the Federal Register in …

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November 11, 2019 7:00 am
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Global Cannabidiol Oil (CBD Oil) Market Expected to Grow at a CAGR of 36% from 2018 to 2023

Global Cannabidiol Oil (CBD Oil) Market Expected to Grow at a CAGR of 36% from 2018 to 2023
The global Cannabidiol oil market is growing at a CAGR of 36% during the forecast period. Hemp and marijuana come from the same plant, cannabis …

https://www.google.com/url?rct=j&sa=t&url=https://markettribunal.com/2019/11/global-cannabidiol-oil-cbd-oil-market-expected-to-grow-at-a-cagr-of-36-from-2018-to-2023/&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNG8sOycuUU9ZxFi5nQy60UHJYCXog
November 11, 2019 6:11 am
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United States: USDA Issues Regulatory Framework For Hemp Production Under 2018 Farm Bill

United States: USDA Issues Regulatory Framework For Hemp Production Under 2018 Farm Bill
An Interim Final Rule will be published in the Federal Register later this week, which will make the U.S. Domestic Hemp Production Program effective.

https://www.google.com/url?rct=j&sa=t&url=http://www.mondaq.com/unitedstates/x/862254/food%2Bdrugs%2Blaw/USDA%2BIssues%2BRegulatory%2BFramework%2Bfor%2BHemp%2BProduction%2BUnder%2B2018%2BFarm%2BBill&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNEmzuvFjy5fqpxzuuLWBdOkHyRRoQ
November 11, 2019 5:27 am
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Khiron Receives Approval to Sell Aceso™ Hemp CBD Brand in Colombia

Khiron Receives Approval to Sell Aceso™ Hemp CBD Brand in Colombia
First Hemp CBD brand to enter Latin American market under Dixie Brands joint venture; Builds on proven Aceso brand acceptance across US …

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November 11, 2019 5:03 am
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United States: Hold On To Your Hemp: USDA Issues Highly Anticipated Rule Governing Hemp

United States: Hold On To Your Hemp: USDA Issues Highly Anticipated Rule Governing Hemp
Cannabidiol (CBD) lovers, rejoice! On October 31, 2019, the U. S. Department of Agriculture (USDA) published its interim final rule (Rule) governing …

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November 11, 2019 4:23 am
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Veterans & First Responders

Veterans & First Responders
Sign-In. Email Address. Password. Remember Me. Register • Forgot your password? Pure American Hemp Oil. Veteran Owned | Made in the USA …

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November 11, 2019 3:59 am
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Law enforcement field tests may not distinguish between marijuana and hemp

Law enforcement field tests may not distinguish between marijuana and hemp
Police in New York boasted about a massive marijuana bust, but the dispensary the delivery was intended for said it was actually legal hemp. A local …

https://www.google.com/url?rct=j&sa=t&url=https://www.fox13news.com/video/624041&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNEFQqklrOP7QAK4c_mRF420Kw04fA
November 11, 2019 3:16 am
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Ogun teenager, others arrested for planting Indian hemp

Ogun teenager, others arrested for planting Indian hemp
“The suspects were accosted on the road and four of them were apprehended with 42 bags containing weed suspected to be Indian hemp.

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November 11, 2019 2:47 am
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What new federal hemp rules mean for Idaho; link to full Idaho Press story

What new federal hemp rules mean for Idaho; link to full Idaho Press story
Attorneys representing a Colorado-based company suing the Idaho State Police for seizing a shipment of hemp in January are pointing to new federal …

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November 11, 2019 2:42 am
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Edinboro family getting into successful hemp business

Edinboro family getting into successful hemp business
An Edinboro man's new venture is hoping to gain him success in the hemp business. Clay Skelton is the owner of Penn's Hemp. He and his family …

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November 11, 2019 2:29 am
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Hemp wagon

Hemp wagon
Hemp CBD products, vaporizers, and a vape station go very well together for huge profits. There has been very few developments in the way the …

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November 11, 2019 2:18 am
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Cannabis-based medicines: Two drugs approved for NHS

Cannabis-based medicines: Two drugs approved for NHS
Clinical trials have shown the oral solution, which contains cannabidiol (CBD), could reduce the number of seizures by up to 40% in some children.

https://www.google.com/url?rct=j&sa=t&url=https://www.bbc.com/news/health-50351868&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNE9_ZD6QzVGEq4iG9uslluel-w-Jw
November 11, 2019 2:06 am
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Wool hemp blend

Wool hemp blend
A wide variety of hemp wool yarns options are available to you, such as anti-pilling, anti-static, and eco-friendly. Fabric infoDetails. The range of yarn …

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November 11, 2019 1:51 am
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'Plant-based, gluten-free and convenient': Soul Seed's first hemp snack taps on multiple big trends

'Plant-based, gluten-free and convenient': Soul Seed's first hemp snack taps on multiple big trends
Australian hemp snacks company Soul Seed has launched its first convenience-based snack into local supermarkets, which it claims to hit multiple …

https://www.google.com/url?rct=j&sa=t&url=https://www.foodnavigator-asia.com/Article/2019/11/11/Plant-based-gluten-free-and-convenient-Soul-Seed-s-first-hemp-snack-taps-on-multiple-big-trends&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNELxg_QgQTzKOxGgEoZkzrgQkoz-g
November 11, 2019 1:34 am
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Akira Botanicals

Akira Botanicals
With the hemp harvest in, we need your help bringing our CBD products to market! | Check out 'Akira Botanicals: CBD Products from the Source' on …

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November 11, 2019 1:25 am
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NC Industrial Hemp Commission Meeting – November 12

NC Industrial Hemp Commission Meeting – November 12
The next meeting of the NC Industrial Hemp Commission will be on Tuesday, Nov. 12, 2019 at 2 p.m. via conference call. Access to the conference call …

https://www.google.com/url?rct=j&sa=t&url=https://industrialhemp.ces.ncsu.edu/2019/11/nc-industrial-hemp-commission-meeting-november-12/%3Fsrc%3Drss&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNHXwSwWHGnBIDVCnYE6jo1FQIfZww
November 11, 2019 1:18 am
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Teenager, three others arrested with 42 bags of Indian hemp

Teenager, three others arrested with 42 bags of Indian hemp
Police in Ogun State have intercepted 42 bags containing weeds suspected to be Indian hemp and arrested four persons, including a teenager, in the …

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November 11, 2019 12:21 am
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Dramatic increase in hemp farming expected in foreseeable future

Dramatic increase in hemp farming expected in foreseeable future
Vote Hemp, a national advocacy organization, estimates U.S. farmers planted 230,000 acres of hemp this year but will harvest only 50 percent to 60 …

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November 11, 2019 12:19 am
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GW Pharmaceuticals receives positive NICE recommendation for EPIDYOLEX® (cannabidiol) oral …

GW Pharmaceuticals receives positive NICE recommendation for EPIDYOLEX® (cannabidiol) oral …
Cannabidiol oral solution and nabiximols are the first and only plant-derived cannabis-based medicines to be routinely reimbursed on the NHS.

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November 11, 2019 12:04 am
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Backdrop of uncertainty for hemp farmers

Backdrop of uncertainty for hemp farmers
MILTON — The hoop houses that stretch as far as the eye can see at Hepworth Farms have been filling rapidly and repeatedly with the hemp harvest, …

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November 10, 2019 11:47 pm
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Veterans Day Discounts: Colorado Businesses Honor Veterans On Monday

Veterans Day Discounts: Colorado Businesses Honor Veterans On Monday
Lastly, Warfighter Hemp is offering a 50% discount on CBD products … “When Warfighter Hemp was founded,” Steve Danyluk wrote in a statement, …

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November 10, 2019 10:02 pm
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Pot or hemp? NYPD bust highlights growing drug confusion

Pot or hemp? NYPD bust highlights growing drug confusion
As the AP noted, hemp often has tested positive for a permissible, trace amount of THC, or tetrahydrocannabinol, the chemical in cannabis causing …

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November 10, 2019 9:49 pm
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PA Hemp grow opportunity

PA Hemp grow opportunity
My name is Rob McIndoe, owner of SWP Hemp, LLC (Southwestern Pennsylvania) and seeking a buyer and/or partnership for my 35 acres of hemp in …

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November 10, 2019 9:30 pm
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RICH MACKE: Hemp, the good weed

RICH MACKE: Hemp, the good weed
With the ongoing discussion about legalization of marijuana, the slang word for cannabis, “Hemp” has been unfortunately thrown into this argument.

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November 10, 2019 7:10 am
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CBDepot Opening in Loveland

CBDepot Opening in Loveland
For those unfamiliar with CBD, it's simply the acronym for cannabidiol, a chemical compound from the cannabis plant. It's not psychoactive like THC …

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November 10, 2019 7:04 am
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State Briefs: Nov. 10, 2019

State Briefs: Nov. 10, 2019
Explosion, fire damage hemp processing plant. WINCHESTER — An explosion and fire have damaged a hemp processing plant in Kentucky.

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November 10, 2019 6:04 am
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Alternative crops help Indiana farmer after trying spring

Alternative crops help Indiana farmer after trying spring
Brian Thompson has typically raised corn and soybeans, but this year, in addition to those crops, he has grown and harvested hemp and grain …

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November 10, 2019 6:02 am
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AP News in Brief at 12:04 am EST

AP News in Brief at 12:04 am EST
The extract that's been showing up in everything from candy to coffee is legally derived from hemp plants, which look and smell an awful lot like that …

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November 10, 2019 5:09 am
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Health care industry braces for fallout from increased marijuana use

Health care industry braces for fallout from increased marijuana use
Michigan State Medical Society has called for more research on health effects of expanded use of marijuana; Confusion exists on hemp-based CBD …

https://www.google.com/url?rct=j&sa=t&url=https://www.crainsdetroit.com/marijuana/health-care-industry-braces-fallout-increased-marijuana-use&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNEF7gAVP2w5rdbyqyeSgkn6K-qYRw
November 10, 2019 5:06 am
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Hemp's budding success in the Mountain State

Hemp's budding success in the Mountain State
Just one year after this sweeping legislation was signed into law by President Donald Trump, West Virginia's hemp industry is booming. From 2017 to …

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November 10, 2019 5:04 am
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Let's grow West Virginia together

Let's grow West Virginia together
I'm confident I could go into any community and mention the words industrial hemp, but when pressed to explain hemp few could converse beyond the …

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November 10, 2019 5:02 am
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Former Employees At Jeannette Hemp-Drying Facility Claim They Have Not Been Paid In Weeks

Former Employees At Jeannette Hemp-Drying Facility Claim They Have Not Been Paid In Weeks
JEANNETTE (KDKA) — Former employees of a hemp-drying facility in Jeannette are fed up, claiming they haven't received their paychecks in weeks.

https://www.google.com/url?rct=j&sa=t&url=https://pittsburgh.cbslocal.com/2019/11/09/workers-claim-they-have-not-been-paid/&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNG83XJi_3D0WuP94WPxCFl1Lbs9hw
November 10, 2019 4:06 am
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Employees At Jeannette Hemp-Drying Facility Claim They Have Not Been Paid In Weeks

Employees At Jeannette Hemp-Drying Facility Claim They Have Not Been Paid In Weeks
Former employees of a hemp-drying facility in Jeannette are fed up after they say they haven't received their paychecks in weeks, KDKA's Shelby …

https://www.google.com/url?rct=j&sa=t&url=https://pittsburgh.cbslocal.com/video/4209225-employees-at-jeannette-hemp-drying-facility-claim-they-have-not-been-paid-in-weeks/&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNGIVbupaut7ox0shil7neF4mbKh5A
November 10, 2019 3:55 am
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Despite risks, Wisconsin hemp industry taking root

Despite risks, Wisconsin hemp industry taking root
Jonathan Baker, owner of TFP Sciences, stands in a field of hemp in rural Whitewater on Oct. 25, 2019. Baker, 29, moved back to Fort Atkinson this …

https://www.google.com/url?rct=j&sa=t&url=https://www.greenbaypressgazette.com/story/news/2019/11/09/despite-risks-wisconsin-hemp-industry-taking-root/2551542001/&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNGhAObSxJHcDxRfJsUfvUZWqOw0dA
November 10, 2019 3:02 am
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Is the Hemp Confusion Helping or Hurting Those Accused?

Is the Hemp Confusion Helping or Hurting Those Accused?
Many of these states, however, have legalized hemp. In fact, 47 states in total have legalized this plant that looks almost identical to marijuana.

https://www.google.com/url?rct=j&sa=t&url=https://bluevirginia.us/2019/11/is-the-hemp-confusion-helping-or-hurting-those-accused&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNFqZTLdLyXajG4YDtkd8AWHYU241Q
November 10, 2019 2:03 am
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Man Arrested For Stealing Hemp He Thought Was Marijuana

Man Arrested For Stealing Hemp He Thought Was Marijuana
It happened around 2 AM Friday morning at a legal hemp farm in Piru. Deputies responded to a report from the security guard hired to protect the legal …

https://www.google.com/url?rct=j&sa=t&url=http://kvta.com/news/man-arrested-for-stealing-hemp-he-thought-was-marijuana/&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNG6DRcLM9MawbLSU0h31QD10hRsNg
November 10, 2019 1:49 am
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mBrace Naturals CBD Health and Wellness Center is good for what ails you!

mBrace Naturals CBD Health and Wellness Center is good for what ails you!
CBD, also known as hemp, has mistakenly been considered the same as cannabis, or marijuana, which is similar in genetic properties but is not …

https://www.google.com/url?rct=j&sa=t&url=http://www.hlntoledo.com/health-and-beauty/2735-mbrace-naturals-cbd-health-and-wellness-center-is-good-for-what-ails-you&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNH1KvgyhgXwzGiI7gqz9LLeWmKgxw
November 10, 2019 1:47 am
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Hemp Farmers Market kicks off grander plans for fast-changing industry

Hemp Farmers Market kicks off grander plans for fast-changing industry
Hemp Farmers Market kicks off grander plans for fast-changing industry … For Sean Holt, an Ashland gathering of Southern Oregon hemp growers …

https://www.google.com/url?rct=j&sa=t&url=https://mailtribune.com/news/top-stories/hemp-farmers-market-kicks-off-grander-plans-for-fast-changing-industry&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNF7R92G6VUA_n6kwXu_AdouvoH5sA
November 10, 2019 1:10 am
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Grow With Hemp

Grow With Hemp
Eventbrite – The Hemp Venture presents Grow With Hemp – Thursday, November 14, 2019 | Thursday, November 21, 2019 at Perimeter Center Area …

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November 10, 2019 12:56 am
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Cannabis industry is drawing big-name investors in RI

Cannabis industry is drawing big-name investors in RI
The other branch of the cannabis business — hemp growing — is also … Hemp is a cousin of marijuana that produces little or no THC but is rich in …

https://www.google.com/url?rct=j&sa=t&url=https://www.providencejournal.com/news/20191109/cannabis-industry-is-drawing-big-name-investors-in-ri&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNFsYRqQ_wRjAzu2ZlRjszYbWCIqZQ
November 10, 2019 12:49 am
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What new federal hemp rules mean for Idaho

What new federal hemp rules mean for Idaho
BOISE — Attorneys representing a Colorado-based company suing the Idaho State Police for seizing a shipment of hemp in January are pointing to …

https://www.google.com/url?rct=j&sa=t&url=https://www.idahopress.com/news/local/what-new-federal-hemp-rules-mean-for-idaho/article_55eb40b8-b3d9-5316-a0ef-f955cfa8d050.html&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNGpkG08KE2UMckGPkR44VdfR3D-Rw
November 10, 2019 12:05 am
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Oregon OSHA fines owners of hemp operation $825K for egregious living and working conditions

Oregon OSHA fines owners of hemp operation $825K for egregious living and working conditions
Courtesy OSHA. One of two padlocked exits at a condemned building in southern Oregon where 25 people were living and working processing hemp.

https://www.google.com/url?rct=j&sa=t&url=https://www.oregonlive.com/pacific-northwest-news/2019/11/oregon-osha-fines-owners-of-hemp-operation-825k-for-egregious-living-and-working-conditions.html&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNEizZtUe3rl5R96lMgaprwQtefwQg
November 9, 2019 11:58 pm
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HempMeds Sleep Support CBD Capsules

HempMeds Sleep Support CBD Capsules
Expertly formulated to naturally promote better sleep and everyday wellbeing, HempMeds Sleep Support CBD Capsules combine full spectrum hemp …

https://www.google.com/url?rct=j&sa=t&url=https://www.medicalmarijuanainc.com/shop/hempmeds-sleep-support-cbd-capsules&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNEr91xc6C9Gz_xfQBuAIxu5NO96Zw
November 9, 2019 11:43 pm
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Influx of hemp stores open in Williamson County

Influx of hemp stores open in Williamson County
FRANKLIN, Tenn. (WTVF) — We've seen it across Middle Tennessee over the last year, more and more people are including CBD and Hemp …

https://www.google.com/url?rct=j&sa=t&url=https://www.newschannel5.com/news/influx-of-hemp-stores-open-in-williamson-county&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNElBARdq2V8r_o1MoAXf5s7Kq0LXA
November 9, 2019 11:29 pm
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Boca Buddha Hemp CBD Delivery Service

Boca Buddha Hemp CBD Delivery Service
For those looking for a full service CBD delivery service in Boca Raton look no further and get Spagyric CBD, tinctures, and spagyric hemp extracts …

https://www.google.com/url?rct=j&sa=t&url=https://patch.com/florida/boca-raton/calendar/event/20191115/694748/boca-buddha-hemp-cbd-delivery-service&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNFkLXlFyX5vG3-qp_CXGZ-wLhh4nA
November 9, 2019 10:29 pm
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King Urging Action to Update Banking Laws for Legal Hemp and Cannabis Businesses

King Urging Action to Update Banking Laws for Legal Hemp and Cannabis Businesses
Senator cites Maine farmers as an example of how federal sector must update rules for now-legal hemp and cannabis businesses. WASHINGTON …

https://www.google.com/url?rct=j&sa=t&url=https://www.king.senate.gov/newsroom/press-releases/king-urging-action-to-update-banking-laws-for-legal-hemp-and-cannabis-businesses&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNGhvChtsQ0t2cAmvor8_iifpNhvWw
November 9, 2019 10:21 pm
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Research Report 2020 Global Hemp Milk Market Current Analysis and Estimated Forecast to 2029 …

Research Report 2020 Global Hemp Milk Market Current Analysis and Estimated Forecast to 2029 …
The report on 'Modest recovery in emerging Global Hemp Milk Market' with in-depth focused approach on subjective research, describing product …

https://www.google.com/url?rct=j&sa=t&url=http://istradingexaminer.com/2019/11/09/global-hemp-milk-market/&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNE9gE3XKSHnvyeH272vJSWc1U-5zQ
November 9, 2019 10:12 pm
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Drake Is Going Into Business With A Canadian Cannabis Firm

Drake Is Going Into Business With A Canadian Cannabis Firm
(CNN) — Cannabis, so hot right now. The burgeoning North American cannabis industry — and, notably, the booming hemp-derived CBD sector …

https://www.google.com/url?rct=j&sa=t&url=https://5newsonline.com/2019/11/09/drake-is-going-into-business-with-a-canadian-cannabis-firm/&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNH1soYgGyFuTt7jpOZEKY8GvO6Q2w
November 9, 2019 9:51 pm
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Super sub Hemp shines as England fall foul to Germany

Super sub Hemp shines as England fall foul to Germany
England's Lauren Hemp (left) and Germany's Kathrin Hendrich battle for the ball during the Women's International Friendly match at Wembley Stadium …

https://www.google.com/url?rct=j&sa=t&url=https://www.eadt.co.uk/sport/lauren-hemp-england-lionesses-wembley-1-6367277&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNHd6rPE962ejjyqLKo5hVdKuf0VhA
November 9, 2019 8:52 pm
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Cannabidiol promotes apoptosis via regulation of XIAP/Smac in gastric cancer.

Cannabidiol promotes apoptosis via regulation of XIAP/Smac in gastric cancer.

Related Articles

Cannabidiol promotes apoptosis via regulation of XIAP/Smac in gastric cancer.

Cell Death Dis. 2019 Nov 07;10(11):846

Authors: Jeong S, Jo MJ, Yun HK, Kim DY, Kim BR, Kim JL, Park SH, Na YJ, Jeong YA, Kim BG, Ashktorab H, Smoot DT, Heo JY, Han J, Il Lee S, Do Kim H, Kim DH, Oh SC, Lee DH

Abstract
According to recent studies, Cannabidiol (CBD), one of the main components of Cannabis sativa, has anticancer effects in several cancers. However, the exact mechanism of CBD action is not currently understood. Here, CBD promoted cell death in gastric cancer. We suggest that CBD induced apoptosis by suppressing X-linked inhibitor apoptosis (XIAP), a member of the IAP protein family. CBD reduced XIAP protein levels while increasing ubiquitination of XIAP. The expression of Smac, a known inhibitor of XIAP, was found to be elevated during CBD treatment. Moreover, CBD treatment increased the interaction between XIAP and Smac by increasing Smac release from mitochondria to the cytosol. CBD has also been shown to affect mitochondrial dysfunction. Taken together, these results suggest that CBD may have potential as a new therapeutic target in gastric cancer.

PMID: 31699976 [PubMed – in process]


https://www.ncbi.nlm.nih.gov/pubmed/31699976?dopt=Abstract

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/erss.cgi?rss_guid=1jYCQzi_o_qLYr-oQfnMhShgOXkvGma3vcnBGJtrBhuJMOvEVJ
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Whole blood transcriptome analysis in ewes fed with hemp seed supplemented diet.

Whole blood transcriptome analysis in ewes fed with hemp seed supplemented diet.

Related Articles

Whole blood transcriptome analysis in ewes fed with hemp seed supplemented diet.

Sci Rep. 2019 Nov 07;9(1):16192

Authors: Iannaccone M, Ianni A, Contaldi F, Esposito S, Martino C, Bennato F, De Angelis E, Grotta L, Pomilio F, Giansante D, Martino G

Abstract
The hemp plant (Cannabis sativa L.) has a long tradition of being used for many different purposes such as industry, medicine and nutrition. In particular, because hemp seed (HS) is rich in oil protein and considerable amounts of dietary fiber, vitamins and minerals that are particularly suitable also for animal nutrition. Different studies have evaluated HS on qualitative and quantitative properties of livestock products but as of today, nobody has investigated the molecular pathway behind HS supplementation in farm animals. Thus, in this study, we will report the first RNA sequencing of the whole-blood transcriptome of ewes fed either with a controlled diet (CTR, n = 5) or with a diet supplemented with 5% of hemp seed (HSG, n = 5). Applying a false discovery rate (FDR) <0.05 and a log2FC either higher than 0.5 or lower than -0.5, we identified 314 differentially regulated genes in the HS-supplemented group compared to the CTR group. Several genes encoding for different subunits belonging to the complex I, II, III, IV and ATP-synthase were up-regulated making oxidative phosphorylation (FDR: 3.05e-19) and thermogenesis (FDR: 2.17e-16) the highest up-regulated pathways in our study. Moreover, we found up-regulation in different genes involved in lactose biosyntheses such as GALK1 and PGM1 and, as a result, we observed a statistically higher lactose percentage in the HSG group (p < 0.05). These results indicate that HS supplementation positively affects the energy production pathway in lactating ewes conferring them also more resistance to adverse climatic conditions such as low temperature. Finally, the higher milk lactose content makes the derived dairy products more profitable.

PMID: 31700124 [PubMed – in process]


https://www.ncbi.nlm.nih.gov/pubmed/31700124?dopt=Abstract

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/erss.cgi?rss_guid=1jYCQzi_o_qLYr-oQfnMhShgOXkvGma3vcnBGJtrBhuJMOvEVJ
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Whole blood transcriptome analysis in ewes fed with hemp seed supplemented diet.

Whole blood transcriptome analysis in ewes fed with hemp seed supplemented diet.

Related Articles

Whole blood transcriptome analysis in ewes fed with hemp seed supplemented diet.

Sci Rep. 2019 Nov 07;9(1):16192

Authors: Iannaccone M, Ianni A, Contaldi F, Esposito S, Martino C, Bennato F, De Angelis E, Grotta L, Pomilio F, Giansante D, Martino G

Abstract
The hemp plant (Cannabis sativa L.) has a long tradition of being used for many different purposes such as industry, medicine and nutrition. In particular, because hemp seed (HS) is rich in oil protein and considerable amounts of dietary fiber, vitamins and minerals that are particularly suitable also for animal nutrition. Different studies have evaluated HS on qualitative and quantitative properties of livestock products but as of today, nobody has investigated the molecular pathway behind HS supplementation in farm animals. Thus, in this study, we will report the first RNA sequencing of the whole-blood transcriptome of ewes fed either with a controlled diet (CTR, n = 5) or with a diet supplemented with 5% of hemp seed (HSG, n = 5). Applying a false discovery rate (FDR) <0.05 and a log2FC either higher than 0.5 or lower than -0.5, we identified 314 differentially regulated genes in the HS-supplemented group compared to the CTR group. Several genes encoding for different subunits belonging to the complex I, II, III, IV and ATP-synthase were up-regulated making oxidative phosphorylation (FDR: 3.05e-19) and thermogenesis (FDR: 2.17e-16) the highest up-regulated pathways in our study. Moreover, we found up-regulation in different genes involved in lactose biosyntheses such as GALK1 and PGM1 and, as a result, we observed a statistically higher lactose percentage in the HSG group (p < 0.05). These results indicate that HS supplementation positively affects the energy production pathway in lactating ewes conferring them also more resistance to adverse climatic conditions such as low temperature. Finally, the higher milk lactose content makes the derived dairy products more profitable.

PMID: 31700124 [PubMed – in process]


https://www.ncbi.nlm.nih.gov/pubmed/31700124?dopt=Abstract

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/erss.cgi?rss_guid=12OY-2YuXEtecDR7WE-A2c-rtPCJqs0e275YvMbwhvRR34bgib
=====================
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Characterization and Preparation of Nano-porous Carbon Derived from Hemp Stems as Anode for Lithium-Ion Batteries.

Characterization and Preparation of Nano-porous Carbon Derived from Hemp Stems as Anode for Lithium-Ion Batteries.

Related Articles

Characterization and Preparation of Nano-porous Carbon Derived from Hemp Stems as Anode for Lithium-Ion Batteries.

Nanoscale Res Lett. 2019 Nov 07;14(1):338

Authors: Guan Z, Guan Z, Li Z, Liu J, Yu K

Abstract
As a biomass waste, hemp stems have the advantages of low cost and abundance, and it is regarded as a promising anode material with a high specific capacity. In this paper, activated carbon derived from hemp stems is prepared by low-temperature carbonization and high-temperature activation. The results of characterizations show the activated carbon has more pores due to the advantages of natural porous structure of hemp stem. The aperture size is mainly microporous, and there are mesopores and macropores in the porous carbon. The porous carbon has an excellent reversible capacity of 495 mAh/g after 100 cycles at 0.2 °C as the anode of lithium-ion battery. Compared with the graphite electrode, the electrochemical property of activated carbon is significantly improved due to the reasonable distribution of pore size. The preparation of the activated carbon provides a new idea for low cost and rapid preparation of anode materials for high capacity lithium-ion batteries.

PMID: 31701241 [PubMed]


https://www.ncbi.nlm.nih.gov/pubmed/31701241?dopt=Abstract

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/erss.cgi?rss_guid=12OY-2YuXEtecDR7WE-A2c-rtPCJqs0e275YvMbwhvRR34bgib
=====================
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Myorelaxant Effect of Transdermal Cannabidiol Application in Patients with TMD: A Randomized, Double-Blind Trial.

Myorelaxant Effect of Transdermal Cannabidiol Application in Patients with TMD: A Randomized, Double-Blind Trial.

Related Articles

Myorelaxant Effect of Transdermal Cannabidiol Application in Patients with TMD: A Randomized, Double-Blind Trial.

J Clin Med. 2019 Nov 06;8(11):

Authors: Nitecka-Buchta A, Nowak-Wachol A, Wachol K, Walczyńska-Dragon K, Olczyk P, Batoryna O, Kempa W, Baron S

Abstract
(1) Background: The healing properties of cannabidiol (CBD) have been known for centuries. In this study, we aimed to evaluate the efficiency of the myorelaxant effect of CBD after the transdermal application in patients with myofascial pain. (2) Methods: The Polish version of the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD Ia and Ib) was used. A total of 60 patients were enrolled in the study and were randomly divided into two groups: Group1 and Group2. The average age in Group1 was 23.2 years (SD) = 1.6 years) and in Group2, it was 22.6 years (SD = 1.86). This was a parallel and double-blind trial. Group1 received CBD formulation, whereas Group2 received placebo formulation for topical use. The masseter muscle activity was measured on days 0 and 14, with surface electromyography (sEMG) (Neurobit Optima 4, Neurobit System, Gdynia, Poland). Pain intensity in VAS (Visual Analogue Scale) was measured on days 0 and 14. (3) Results: in Group1, the sEMG masseter activity significantly decreased (11% in the right and 12.6% in the left masseter muscles). In Group2, the sEMG masseter activity was recorded as 0.23% in the right and 3.3% in the left masseter muscles. Pain intensity in VAS scale was significantly decreased in Group1: 70.2% compared to Group2: 9.81% reduction. Patients were asked to apply formulation twice a day for a period of 14 days. (4) Conclusion: The application of CBD formulation over masseter muscle reduced the activity of masseter muscles and improved the condition of masticatory muscles in patients with myofascial pain.

PMID: 31698733 [PubMed]


https://www.ncbi.nlm.nih.gov/pubmed/31698733?dopt=Abstract

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/erss.cgi?rss_guid=1BE6Yf6ex8r6DRZaKzQi_iKP-GeW6jP4zTLhuJ2dzIMGHW_IGQ
=====================
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Cannabidiol promotes apoptosis via regulation of XIAP/Smac in gastric cancer.

Cannabidiol promotes apoptosis via regulation of XIAP/Smac in gastric cancer.

Related Articles

Cannabidiol promotes apoptosis via regulation of XIAP/Smac in gastric cancer.

Cell Death Dis. 2019 Nov 07;10(11):846

Authors: Jeong S, Jo MJ, Yun HK, Kim DY, Kim BR, Kim JL, Park SH, Na YJ, Jeong YA, Kim BG, Ashktorab H, Smoot DT, Heo JY, Han J, Il Lee S, Do Kim H, Kim DH, Oh SC, Lee DH

Abstract
According to recent studies, Cannabidiol (CBD), one of the main components of Cannabis sativa, has anticancer effects in several cancers. However, the exact mechanism of CBD action is not currently understood. Here, CBD promoted cell death in gastric cancer. We suggest that CBD induced apoptosis by suppressing X-linked inhibitor apoptosis (XIAP), a member of the IAP protein family. CBD reduced XIAP protein levels while increasing ubiquitination of XIAP. The expression of Smac, a known inhibitor of XIAP, was found to be elevated during CBD treatment. Moreover, CBD treatment increased the interaction between XIAP and Smac by increasing Smac release from mitochondria to the cytosol. CBD has also been shown to affect mitochondrial dysfunction. Taken together, these results suggest that CBD may have potential as a new therapeutic target in gastric cancer.

PMID: 31699976 [PubMed – in process]


https://www.ncbi.nlm.nih.gov/pubmed/31699976?dopt=Abstract

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/erss.cgi?rss_guid=1BE6Yf6ex8r6DRZaKzQi_iKP-GeW6jP4zTLhuJ2dzIMGHW_IGQ
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Reefer madness or real medicine? A plea for incorporating medicinal cannabis in pharmacy curricula.

Reefer madness or real medicine? A plea for incorporating medicinal cannabis in pharmacy curricula.

Icon for Elsevier Science Related Articles

Reefer madness or real medicine? A plea for incorporating medicinal cannabis in pharmacy curricula.

Curr Pharm Teach Learn. 2018 09;10(9):1165-1167

Authors: Abazia DT, Bridgeman MB

Abstract
INTRODUCTION: Over the past twenty years, the acceptance and use of medicinal cannabis has increased in the United States. However, there is still a lack of education and comfort as it relates to the therapeutic uses of botanical cannabis and cannabidiol in pharmacy professional curricula. Professional training programs have failed to keep pace with the evolving national landscape and growing acceptance of this therapy.
PERSPECTIVE: In this manuscript, the current landscape of pharmacy professional involvement in the dispensing and administration of medicinal cannabis throughout the United States is described. A concern exists that there is a knowledge gap among pharmacists and pharmacy students, as demonstrated by recent survey results, related to the pharmacology, dosing, administration, adverse effects, drug interactions, and monitoring of both medicinal and recreational cannabis use.
IMPLICATIONS: While cannabis use is still considered illegal by the federal government, it is imperative pharmacy educators prepare the next generation of pharmacists to be knowledgeable on the safe and effective use and communication tactics related to cannabis. As a therapy garnering national attention with growing support for use, education on this topic must be included in pharmacy curricula and pharmacy continuing education.

PMID: 30497617 [PubMed – indexed for MEDLINE]


https://www.ncbi.nlm.nih.gov/pubmed/30497617?dopt=Abstract

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/erss.cgi?rss_guid=1BE6Yf6ex8r6DRZaKzQi_iKP-GeW6jP4zTLhuJ2dzIMGHW_IGQ
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Can Industrial Hemp Make Automobiles More Green?

Can Industrial Hemp Make Automobiles More Green?
Hemp's use in the making of automobiles is not new; manufacturers such as Ford experimented with using the plant to make and fuel cars. Although …

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Hemp Toilet Paper Could Change The World

Hemp Toilet Paper Could Change The World
Hemp pulp paper can be made without any chemicals from the hemp … Toilet paper, made from the industrial hemp plant, has been marketed in other …

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Straight Hemp Launches CBD Line In Earth Fare Stores

Straight Hemp Launches CBD Line In Earth Fare Stores
Arvada, Colorado-based CBD wellness company Straight Hemp has launched its CBD oil and balm products in wellness supermarket chain Earth …

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Georgia moves closer to legal hemp production

Georgia moves closer to legal hemp production
Hemp is used to make CBD, the suddenly popular compound extracted from the cannabis plant. Marketers say CBD can treat a range of ailments …

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A New California Law Will Affect Marijuana and Hemp Businesses Across the Nation

A New California Law Will Affect Marijuana and Hemp Businesses Across the Nation
We've been writing a lot lately about recent major changes in federal hemp laws that will likely affect every hemp company in the United States (see …

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Is it pot or not? Busts show growing confusion over legal hemp

Is it pot or not? Busts show growing confusion over legal hemp
The CBD craze might be leaving the war on drugs a bit dazed and confused. The extract that's been showing up in everything from candy to coffee is …

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Pot or Not? Police Busts Highlight Growing Confusion Over Hemp, CBD

Pot or Not? Police Busts Highlight Growing Confusion Over Hemp, CBD
The CBD craze is leaving the war on drugs a bit dazed and confused. The extract that's been showing up in everything from candy to coffee is legally …

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Pot or not? Busts highlight growing confusion over hemp

Pot or not? Busts highlight growing confusion over hemp
NEW YORK — The CBD craze might be leaving the war on drugs a bit dazed and confused. The extract that's been showing up in everything from …

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AgweekTV Full Show: Hunter Hanson overview, grain drying, SD industrial hemp

AgweekTV Full Show: Hunter Hanson overview, grain drying, SD industrial hemp
This week on AgweekTV, we re-examine the fraud case of young grain trader Hunter Hanson as his sentencing day approaches. With this year's late …

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CBD Hemp Shoppe – 2019 All You Need to Know BEFORE You Go (with Photos) Vitamins …

CBD Hemp Shoppe – 2019 All You Need to Know BEFORE You Go (with Photos) Vitamins …
We provide high-quality, third party tested, hemp based products, many from small, locally owned farms and companies. We are also here to help you …

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DON forum shows multiple uses of hemp plant

DON forum shows multiple uses of hemp plant
Why don't we think about growing our homes locally? That was one question raised at the Western PA Hemp Fiber Educational Series inaugural …

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Hemp, Inc. Oregon Processing Operation Featured in NewsWatch 12's Harvest Coverage

Hemp, Inc. Oregon Processing Operation Featured in NewsWatch 12's Harvest Coverage
Las Vegas, NV, Nov. 06, 2019 (GLOBE NEWSWIRE) — via NEWMEDIAWIRE — Hemp, Inc. (OTC PINK: HEMP) announced today news coverage in …

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Hemp farmers discuss challenges

Hemp farmers discuss challenges
Some might call it a labor of love, but Wilken's passion for helping people manage their pain with hemp, comes with its fair share of labor.

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Alleged hemp theft in Piru leads to arrest of 70-year-old man

Alleged hemp theft in Piru leads to arrest of 70-year-old man
Authorities arrested a 70-year-old man allegedly caught trying to steal bags of hemp from a legal growing operation in Piru early Friday. The incident …

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Idaho family grows hemp in Oregon

Idaho family grows hemp in Oregon
The Fletcher family knows the success of its first hemp-growing season could be tough to repeat come 2020. “It's really finicky,” Vale-based farmer …

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Cannabidiol increases the nociceptive threshold in a preclinical model of Parkinson's disease

Cannabidiol increases the nociceptive threshold in a preclinical model of Parkinson's disease
The CBD treatment decreases hyperalgesia and allodynia in experimental … agonist of the CB1 receptor prevents the antinociceptive effect of CBD.

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November 9, 2019 4:42 am
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Hemp researcher reportedly files $1 billion claim against Kern over crop eradication

Hemp researcher reportedly files $1 billion claim against Kern over crop eradication
A locally registered hemp researcher has reportedly filed a $1 billion claim against Kern County over what he says was the "illegal and unlawful …

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Grand Island sees another CBD store open

Grand Island sees another CBD store open
According to healthline.com, cannabidiol (CBD) is a natural remedy that's becoming popular with the public. It's used for many common ailments, …

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This is a first! Circa 1865 farm, now a hemp farm. 12 acres in the NC

This is a first! Circa 1865 farm, now a hemp farm. 12 acres in the NC
This is a first on this page. This farm was built in 1865. It is located on 12.5 acres in Waynesville, North Carolina. This is currently operating as a hemp …

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Minnesota farmer harvests first hemp crop in Hubbard County

Minnesota farmer harvests first hemp crop in Hubbard County
LAKE GEORGE, Minn. — Jeri Scovel hurriedly harvested her first crop of industrial hemp last month. “I've just been praying that it doesn't snow,” she …

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Hemp update: Wisconsin Opens 2020 Growing Season Applications While USDA Issues Interim …

Hemp update: Wisconsin Opens 2020 Growing Season Applications While USDA Issues Interim …
The second year of the industrial hemp pilot program in Wisconsin saw immense growth in the number of licensed growers and processors statewide.

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USDA Releases Highly Anticipated Interim Final Rule for Hemp Production

USDA Releases Highly Anticipated Interim Final Rule for Hemp Production
On October 29, 2019, The U.S. Department of Agriculture released its interim final rule for the domestic production of hemp, which provides hemp …

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Industrial hemp workshop planned for next weekend in Warrenton

Industrial hemp workshop planned for next weekend in Warrenton
Speakers will include MU Extension specialists, the Missouri Department of Agriculture's hemp program director, Missouri Hemp Trade Association …

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Cbd formula

Cbd formula
3 of the psychoactive compound, THC, and Pure Calm CBD has close to … CBD, or cannabidiol, oil is currently being studied for its health benefits.

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Columbia OKs industrial hemp awareness fair as park fundraiser

Columbia OKs industrial hemp awareness fair as park fundraiser
When: Council meeting, Nov. 7. What happened: Council members gave a tentative nod of approval for an industrial hemp awareness fair to be held …

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The Top CBD Products of 2019: The Men's Health CBD Awards

The Top CBD Products of 2019: The Men's Health CBD Awards
CBD, for all you non-Farm-Bill readers, is shorthand for "cannabidiol," and you're … These are our winners of the first-ever Men's Health CBD Awards.

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November 8, 2019 9:11 pm
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Summit to focus on hemp production

Summit to focus on hemp production
The Illinois Department of Agriculture will host a summit to discuss hemp production and address questions raised by farmers following the release of …

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November 8, 2019 9:01 pm
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The Cannabis Catch-Up: The Trouble With Hemp

The Cannabis Catch-Up: The Trouble With Hemp
A recent kerfuffle involving a Vermont hemp farm and the New York Police Department laid bare the evolving understanding of cannabis laws.

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November 8, 2019 8:52 pm
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Kentucky Hemp/CBD Symposium Expo

Kentucky Hemp/CBD Symposium Expo
Ever wondered what all the hype is about CBD oil? Do you use it already but want to learn more about how it's produced? Or perhaps you are …

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November 8, 2019 8:48 pm
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On CBD: What do you want to know, and what has been your experience? LNP wants to talk to you

On CBD: What do you want to know, and what has been your experience? LNP wants to talk to you
Another option for drying hemp is an industrial-sized dryer owned by Keystone Agri-Science. At right, Caleb Kauffman checks the moisture content in …

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November 8, 2019 8:28 pm
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USDA Releases Hemp Growing Regulations For States

USDA Releases Hemp Growing Regulations For States
The U.S Department of Agriculture (USDA) recently released its regulatory framework that states must follow if they plan to grow hemp. The Wyoming …

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November 8, 2019 8:19 pm
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Third Wave Farms opens hemp processing plant in Kokomo

Third Wave Farms opens hemp processing plant in Kokomo
KOKOMO — Third Wave Farms has opened it's first hemp drying and processing facility in Kokomo, according to a press release.

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November 8, 2019 7:39 pm
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Not guilty plea for man transporting hemp

Not guilty plea for man transporting hemp
RAPID CITY, S.D. (AP) — The Colorado man who was arrested in South Dakota after his load of hemp tested positive for THC, the component in …

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November 8, 2019 7:30 pm
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Effect of Vaporized Cannabis on Exertional Breathlessness and Exercise Endurance in Advanced Chronic Obstructive Pulmonary Disease. A Randomized Controlled Trial.

Effect of Vaporized Cannabis on Exertional Breathlessness and Exercise Endurance in Advanced Chronic Obstructive Pulmonary Disease. A Randomized Controlled Trial.

Related Articles

Effect of Vaporized Cannabis on Exertional Breathlessness and Exercise Endurance in Advanced Chronic Obstructive Pulmonary Disease. A Randomized Controlled Trial.

Ann Am Thorac Soc. 2018 10;15(10):1146-1158

Authors: Abdallah SJ, Smith BM, Ware MA, Moore M, Li PZ, Bourbeau J, Jensen D

Abstract
RATIONALE: A series of studies conducted approximately 40 years ago demonstrated an acute bronchodilator effect of smoked cannabis in healthy adults and adults with asthma. However, the acute effects of vaporized cannabis on airway function in adults with advanced chronic obstructive pulmonary disease (COPD) remain unknown.
OBJECTIVES: To test the hypothesis that inhaled vaporized cannabis would alleviate exertional breathlessness and improve exercise endurance by enhancing static and dynamic airway function in COPD.
METHODS: In a randomized controlled trial of 16 adults with advanced COPD (forced expiratory volume in 1 second [FEV1], mean ± SD: 36 ± 11% predicted), we compared the acute effect of 35 mg of inhaled vaporized cannabis (18.2% Δ9-tetrahydrocannabinol, <0.1% cannabidiol) versus 35 mg of a placebo control cannabis (CTRL; 0.33% Δ9-tetrahydrocannabinol, <0.99% cannabidiol) on physiological and perceptual responses during cardiopulmonary cycle endurance exercise testing; spirometry and impulse oscillometry at rest; and cognitive function, psychoactivity, and mood.
RESULTS: Compared with CTRL, cannabis had no effect on breathlessness intensity ratings during exercise at isotime (cannabis, 2.7 ± 1.2 Borg units vs. CTRL, 2.6 ± 1.3 Borg units); exercise endurance time (cannabis, 3.8 ± 1.9 min vs. CTRL, 4.2 ± 1.9 min); cardiac, metabolic, gas exchange, ventilatory, breathing pattern, and/or operating lung volume parameters at rest and during exercise; spirometry and impulse oscillometry-derived pulmonary function test parameters at rest; and cognitive function, psychoactivity, and mood.
CONCLUSIONS: Single-dose inhalation of vaporized cannabis had no clinically meaningful positive or negative effect on airway function, exertional breathlessness, and exercise endurance in adults with advanced COPD. Clinical trial registered with www.clinicaltrials.gov (NCT03060993).

PMID: 30049223 [PubMed – indexed for MEDLINE]


https://www.ncbi.nlm.nih.gov/pubmed/30049223?dopt=Abstract

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6 Things You Need To Know When Shopping For CBD Oil

6 Things You Need To Know When Shopping For CBD Oil
Shopping for CBD oil, especially when you're new to all things hemp and cannabis, can be overwhelming. Do you need CBD pills or CBD oil? What's …

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November 8, 2019 7:23 pm
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CBD Beauty Brand Cannuka to Participate in Cowen's 2nd Annual Cannabis Conference in Boston

CBD Beauty Brand Cannuka to Participate in Cowen's 2nd Annual Cannabis Conference in Boston
Cincinnati, Ohio, Nov. 08, 2019 (GLOBE NEWSWIRE) — Cannuka, LLC (“Cannuka” or the “Company”), a leading cannabidiol (“CBD”) beauty and …

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Hemp applications open for 2020

Hemp applications open for 2020
(WFRV) – Applications are now open to grow hemp in our state next year. But, before your dig into this emerging crop, there are some important things …

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Can We Get Behind Hemp Yet?

Can We Get Behind Hemp Yet?
What are the barriers preventing the return to hemp products in the US and more specifically VT? Can we possibly overcome these barriers?

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November 8, 2019 7:16 pm
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Hemp Farmer Says New York Police Mistook Hemp Shipment as Marijuana

Hemp Farmer Says New York Police Mistook Hemp Shipment as Marijuana
Police in New York last week intercepted and seized a shipment of organic hemp, allegedly mistaking it for marijuana. Vermont's NBC-5 reports Fox …

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November 8, 2019 6:35 pm
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USDA to build nation's first industrial hemp seed bank at Cornell

USDA to build nation's first industrial hemp seed bank at Cornell
Alaina Potrikus | [email protected] Cornell researcher Larry Smart addresses the crowd at Cornell Industrial Hemp Research Team Field Day in August …

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Now in Effect: Oklahoma Law Decriminalizes CBD Despite Ongoing FDA Prohibition

Now in Effect: Oklahoma Law Decriminalizes CBD Despite Ongoing FDA Prohibition
OKLAHOMA CITY, Okla. (Nov. 8, 2019) – Last week, an Oklahoma law that decriminalizes hemp-derived cannabidiol went into effect. This will not only …

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Hemp Summit hosted by Ill. Department of Agriculture

Hemp Summit hosted by Ill. Department of Agriculture
"We've heard from the hemp farming community and understand their concerns related to the USDA rules,” said Jeff Cox, IDOA Bureau Chief for …

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Med Roots of Highland becomes area's latest CBD shop

Med Roots of Highland becomes area's latest CBD shop
"I felt that, with the federal legalization of hemp in the 2018 farm bill, this was the best way I could bring the medicine to the people on a larger scale," …

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Workers at Jeannette hemp warehouse protest lack of pay

Workers at Jeannette hemp warehouse protest lack of pay
4 minutes ago. Former employees of a Jeannette hemp-drying facility stood in frigid temperatures outside the controversial business Friday morning, …

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Your Legal Hemp Defense Is Still Good In North Carolina– For Now

Your Legal Hemp Defense Is Still Good In North Carolina– For Now
Starting June 1, 2020, smokeable hemp will be illegal in North Carolina. Smokeable hemp isn't actually any more harmful than a cigarette, but …

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November 8, 2019 3:00 pm
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Explosion and fire damages major hemp processing facility in Kentucky, authorities say

Explosion and fire damages major hemp processing facility in Kentucky, authorities say
An explosion and fire Thursday night caused significant damage to a GenCanna hemp processing facility in Kentucky, according to authorities.

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November 8, 2019 2:52 pm
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WI Hemp Production Sees Rapid Growth, Despite Frustrations

WI Hemp Production Sees Rapid Growth, Despite Frustrations
MADISON, Wis. – Going into its third year, Wisconsin's hemp pilot research program is frustrating some farmers, but state officials say that's because of …

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November 8, 2019 2:39 pm
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Lemongrass CBD Infused Massage Oil

Lemongrass CBD Infused Massage Oil
Massage Cannabyss CBD infused lemongrass massage oil with full-spectrum hemp extract provides a deep and seemingly endless abyss of some of …

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Gold Label 10g CBD Hemp Oil (2400mg CBD)

Gold Label 10g CBD Hemp Oil (2400mg CBD)
RSHO Gold Label CBD hemp oil 3-pack contains 2400mg of CBD in each of three 10g oral applicators. Real Scientific Hemp Oil brand of pure CBD oil.

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November 8, 2019 11:40 am
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Creating a legal exception for CBD supplements, short of full safety data, could set a bad precedent …

Creating a legal exception for CBD supplements, short of full safety data, could set a bad precedent …
Dietary supplement industry groups are pressing FDA to legalize the use of the hemp cannabinoid cannabidiol (CBD) in dietary supplements, but FDA …

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November 8, 2019 6:13 am
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Holistic Pet Wellness And Hemp CBD

Holistic Pet Wellness And Hemp CBD
While many state regulatory agencies focus on human uses for CBD, some states recognize consumers are increasingly purchasing CBD for use in …

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November 8, 2019 6:07 am
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Hemp CBD Connex

Hemp CBD Connex
In this sixth year of the conference, we explore the expansion of the industry beyond cannabis, highlighting the vast potential of hemp and CBD …

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November 8, 2019 3:37 am
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FL Agriculture Commissioner working on new hemp law and regulating CBD

FL Agriculture Commissioner working on new hemp law and regulating CBD
SARASOTA, Fla. (WWSB) – “We're creating standards which don't exist right now,” Florida's Commissioner of Agriculture and Consumer Services Nikki …

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November 8, 2019 2:52 am
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Hemp farmer to lose millions if samples seized by Chattanooga PD aren't recovered soon

Hemp farmer to lose millions if samples seized by Chattanooga PD aren't recovered soon
Taylor Smith is the owner of H3 Research Hemp Farm, and sends her products to local testing facility New Bloom Labs to have hemp samples tested …

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November 8, 2019 2:15 am
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Montana Ag Network: Hemp being considered for construction uses

Montana Ag Network: Hemp being considered for construction uses
Hemp has captured the spotlight over the past few years, especially with its many uses. Through a recent collaboration with the Montana Farmers …

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November 8, 2019 12:33 am
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Is a Hemp Checkoff Coming from USDA?

Is a Hemp Checkoff Coming from USDA?
A USDA official said earlier this week that the U.S. hemp industry could have a producer-funded checkoff program coming soon. The Agricultural …

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November 8, 2019 12:02 am
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New Hemp Federation heads to DC as farmers face lack of markets

New Hemp Federation heads to DC as farmers face lack of markets
The newly formed Hemp Federation of America is planning its first fly-in to Washington next week, just as Reuters reported that the farmers are having …

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November 7, 2019 11:12 pm
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Buy CBD Oil Online at Medical Marijuana Inc.

Buy CBD Oil Online at Medical Marijuana Inc.
Browse our catalog of legal cannabis, marijuana, hemp derived products for online purchase, including hemp CBD oil supplements, skin care, hair …

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November 7, 2019 10:19 pm
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PathogenDx, Icon Farms To Collaborate In The Development Of Hemp-Specific Testing Standards

PathogenDx, Icon Farms To Collaborate In The Development Of Hemp-Specific Testing Standards
PathogenDx, an Arizona-based pathogen-testing technology company, announced this week a strategic partnership with hemp operator and …

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November 7, 2019 10:01 pm
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Farmers Struggle as Hemp Harvest Winds Down

Farmers Struggle as Hemp Harvest Winds Down
PHOENIX, Ore. — Ajit Singh strode across his 16-acre hemp field toward a broken-down harvester. He'd been hoping all day that the mechanic now …

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November 7, 2019 9:59 pm
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US Hemp: Field Of Pipe Dreams?

US Hemp: Field Of Pipe Dreams?
In 2017 the state of Tennessee licensed 200 acres for the cultivation of hemp. That figure shot up to 3,338 acres in 2018 — and 38,000 acres in the …

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November 7, 2019 9:58 pm
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Canopy Freed From Hemp Grower's $1.9M Suit

Canopy Freed From Hemp Grower's $1.9M Suit
U.S. District Judge David G. Larimer said another judge, who has since recused herself from the case, previously told Go Farm Hemp LLC that its …

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November 7, 2019 9:35 pm
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[email protected]: Thousands of US hemp farmers left without buyers | Coca-Cola, Nestlé, PepsiCo named …

[email protected]: Thousands of US hemp farmers left without buyers | Coca-Cola, Nestlé, PepsiCo named …
65% of hemp farmers surveyed by White Economics stated that they currently cannot find a buyer for their crop. The price for hemp also dropped in …

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November 7, 2019 9:33 pm
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Free MU Extension guides help prospective industrial hemp growers

Free MU Extension guides help prospective industrial hemp growers
COLUMBIA, Mo. – University of Missouri Extension specialists have developed educational guides for those interested in growing industrial hemp.

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November 7, 2019 9:12 pm
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High Fiber Cakes from Mediterranean Multipurpose Oilseeds as Protein Sources for Ruminants.

High Fiber Cakes from Mediterranean Multipurpose Oilseeds as Protein Sources for Ruminants.

Related Articles

High Fiber Cakes from Mediterranean Multipurpose Oilseeds as Protein Sources for Ruminants.

Animals (Basel). 2019 Nov 04;9(11):

Authors: Serrapica F, Masucci F, Raffrenato E, Sannino M, Vastolo A, Barone CMA, Di Francia A

Abstract
Fifteen oilseed cakes from sunflower, pomegranate, cardoon, tobacco and hemp were characterized with regard to chemical composition, Cornell Net Carbohydrate and Protein System (CNCPS) fractionation, in vitro digestibility of dry matter, neutral detergent fiber, and crude protein. All the cakes presented low moisture, rather variable ether extract contents and medium to high levels of crude protein and neutral detergent fiber. The cakes significantly differed in terms of CNCPS partitioning and in vitro digestibility. Tobacco and hemp cakes presented high contents of slow degradable fractions of crude protein and carbohydrate joined to good post-ruminal protein digestibility. Cardoon cakes presented the highest rumen protein degradability. Based on crude protein content and intestinal digestibility of rumen undegraded protein, cakes of tobacco and hemp showed the better potential as alternative protein supplements for ruminants, while pomegranate appears to be the least suitable for ruminant feeding.

PMID: 31690014 [PubMed]


https://www.ncbi.nlm.nih.gov/pubmed/31690014?dopt=Abstract

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/erss.cgi?rss_guid=12OY-2YuXEtecDR7WE-A2c-rtPCJqs0e275YvMbwhvRR34bgib
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Hemp (Cannabis sativa L.) Protein Extraction Conditions Affect Extraction Yield and Protein Quality.

Hemp (Cannabis sativa L.) Protein Extraction Conditions Affect Extraction Yield and Protein Quality.

Related Articles

Hemp (Cannabis sativa L.) Protein Extraction Conditions Affect Extraction Yield and Protein Quality.

J Food Sci. 2019 Nov 06;:

Authors: Potin F, Lubbers S, Husson F, Saurel R

Abstract
The purpose of this paper was to study the extraction conditions of hemp proteins from undelipidated press-cakes. The effects of different hydration conditions on protein recovery yield and polypeptide profile were evaluated: pH (2 to 12), ionic strength (0 to 500 mM NaCl) and press-cake/liquid weight ratio (2% to 22%). pH was the most impacting factor. At acidic pH (2 to 7) the extraction yields were low and quite constant (<7%), corresponding mainly to hemp albumins solubilization. The extraction of globulins started to increase significantly from pH 8, with protein extraction yield varying from 8.3% at pH 8 to 67.1% at pH 12 for a 10% press-cake/liquid weight ratio. The addition of NaCl in press-cake suspensions did not increase the total nitrogen content in aqueous extracts at alkaline pH while the lowest press-cake/liquid weight ratios (5% to 10%) were revealed optimal regarding protein recovery rate. The intense coloration observed on the aqueous extracts above pH 8 was assigned to solubilization and oxidation of phenolic compounds whose concentration increased about sevenfolds from pH 2 to 12. At the highest applied pH (11 to 12), the formation of covalent complexes between phenolic compounds and some hemp polypeptides was hypothesized. Aqueous extraction at strong alkaline pH (>9) without salt addition and respecting a 10% press-cake/liquid weight ratio should be retained to optimize protein extraction yield. However, further purification steps are required to evaluate the nutritional, organoleptic, and techno-functional properties of hemp proteins extracted in such conditions. PRACTICAL APPLICATION: The traditional extraction process of hemp proteins by alkaline solubilization and isoelectric precipitation, mostly from delipidated hemp press-cake, leads to limited quantity and poor solubility of extracted proteins, and data related to extraction conditions are insufficiently available to optimize this process. This article aims to find optimal hydration conditions (pH, ionic strength, press-cake to liquid ratio) for protein extraction from undelipidated hemp press-cake, allowing high protein recovery and preserving protein quality. The results obtained represent very useful data for developing an economically viable and sustainable extraction process of proteins from raw hemp press-cake.

PMID: 31691301 [PubMed – as supplied by publisher]


https://www.ncbi.nlm.nih.gov/pubmed/31691301?dopt=Abstract

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/erss.cgi?rss_guid=12OY-2YuXEtecDR7WE-A2c-rtPCJqs0e275YvMbwhvRR34bgib
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Hemp Fleece

Hemp Fleece
The Monterey Top — Regular price $165 · The Alpine Pant | BrickPants – sugarcandymtn.com. The Alpine Pant — Regular price $189 …

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November 7, 2019 8:04 pm
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A Special Exception for CBD in Foods and Supplements?

A Special Exception for CBD in Foods and Supplements?

Related Articles

A Special Exception for CBD in Foods and Supplements?

Drug Discov Today. 2019 Nov 02;:

Authors: Zettler PJ, Lietzan E

PMID: 31689508 [PubMed – as supplied by publisher]


https://www.ncbi.nlm.nih.gov/pubmed/31689508?dopt=Abstract

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Pharmacokinetics of Phytocannabinoid Acids and Anticonvulsant Effect of Cannabidiolic Acid in a Mouse Model of Dravet Syndrome.

Pharmacokinetics of Phytocannabinoid Acids and Anticonvulsant Effect of Cannabidiolic Acid in a Mouse Model of Dravet Syndrome.

Related Articles

Pharmacokinetics of Phytocannabinoid Acids and Anticonvulsant Effect of Cannabidiolic Acid in a Mouse Model of Dravet Syndrome.

J Nat Prod. 2019 Nov 05;:

Authors: Anderson LL, Low IK, Banister SD, McGregor IS, Arnold JC

Abstract
Cannabis sativa produces a complex mixture of many bioactive molecules including terpenophenolic compounds known as phytocannabinoids. Phytocannabinoids come in neutral forms (e.g., Δ9-tetrahydrocannabinol, THC; cannabidiol, CBD; etc.) or as acid precursors, which are dominant in the plant (e.g., Δ9-tetrahydrocannabinolic acid, THCA; cannabidiolic acid, CBDA; etc.). There is increasing interest in unlocking the therapeutic applications of the phytocannabinoid acids; however, the present understanding of the basic pharmacology of phytocannabinoid acids is limited. Herein the brain and plasma pharmacokinetic profiles of CBDA, THCA, cannabichromenic acid (CBCA), cannabidivarinic acid (CBDVA), cannabigerolic acid (CBGA), and cannabigerovarinic acid (CBGVA) were examined following intraperitoneal administration in mice. Next it was examined whether CBDA was anticonvulsant in a mouse model of Dravet syndrome (Scn1aRX/+ mice). All the phytocannabinoid acids investigated were rapidly absorbed with plasma tmax values of between 15 and 45 min and had relatively short half-lives (<4 h). The brain-plasma ratios for the acids were very low at ≤0.04. However, when CBDA was administered in an alternate Tween 80-based vehicle, it exhibited a brain-plasma ratio of 1.9. The anticonvulsant potential of CBDA was examined using this vehicle, and it was found that CBDA significantly increased the temperature threshold at which the Scn1aRX/+ mice had a generalized tonic-clonic seizure.

PMID: 31686510 [PubMed – as supplied by publisher]


https://www.ncbi.nlm.nih.gov/pubmed/31686510?dopt=Abstract

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/erss.cgi?rss_guid=1BE6Yf6ex8r6DRZaKzQi_iKP-GeW6jP4zTLhuJ2dzIMGHW_IGQ
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A new mechanism for Cannabidiol in regulating the one-carbon cycle and methionine levels in Dictyostelium and in mammalian epilepsy models.

A new mechanism for Cannabidiol in regulating the one-carbon cycle and methionine levels in Dictyostelium and in mammalian epilepsy models.

Related Articles

A new mechanism for Cannabidiol in regulating the one-carbon cycle and methionine levels in Dictyostelium and in mammalian epilepsy models.

Br J Pharmacol. 2019 Nov 06;:

Authors: Perry CJ, Finch P, Müller-Taubenberger A, Leung KY, Warren EC, Damstra-Oddy J, Sharma D, Patra PH, Glyn S, Boberska J, Stewart B, Baldwin A, Piscitelli F, Harvey RJ, Harwood A, Thompson C, Claus S, Greene NDE, McNeish A, Williams CM, Whalley BJ, Williams RSB

Abstract
Background and Purpose EpidiolexTM , a form of highly purified cannabidiol (CBD) derived from Cannabis plants has demonstrated seizure control activity in patients with Dravet syndrome, without a fully-elucidated mechanism of action. We have employed an unbiased approach to investigate this mechanism at a cellular level. Experimental Approach We use a tractable biomedical model organism, Dictyostelium, to identify protein controlling the effect of CBD and characterize this mechanism. We then translate these results to a Dravet Syndrome mouse model and an acute in vitro seizure model. Key Results CBD activity is partially dependent upon the mitochondrial glycine cleavage system component, GcvH1 in Dictyostelium, orthologous to the human GCSH protein, which is functionally linked to folate one-carbon metabolism (FOCM). Analysis of FOCM components identified a mechanism for CBD in directly inhibiting methionine synthesis. Analysis of brain tissue from a Dravet syndrome mouse model also showed drastically altered levels of one-carbon components including methionine, and an in vitro rat seizure model showed an elevated level of methionine that is attenuated following CBD treatment. Conclusions and Implications Our results suggest a novel mechanism for CBD in the regulating methionine levels, and identify altered one-carbon metabolism in Dravet syndrome and seizure activity.

PMID: 31693171 [PubMed – as supplied by publisher]


https://www.ncbi.nlm.nih.gov/pubmed/31693171?dopt=Abstract

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/erss.cgi?rss_guid=1BE6Yf6ex8r6DRZaKzQi_iKP-GeW6jP4zTLhuJ2dzIMGHW_IGQ
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Cannabis y los sistemas exocannabinoide y endocannabinoide. Su uso y controversias.

Cannabis y los sistemas exocannabinoide y endocannabinoide. Su uso y controversias.

Related Articles

Cannabis y los sistemas exocannabinoide y endocannabinoide. Su uso y controversias.

Gac Med Mex. 2019;155(5):508-512

Authors: Millán-Guerrero RO, Isais-Millán S

Abstract
Cannabis (marijuana) is one of the most consumed psychoactive substances in the world. The term marijuana is of Mexican origin. The primary cannabinoids that have been studied to date include cannabidiol and delta-9-tetrahydrocannabinol, which is responsible for most cannabis physical and psychotropic effects. Recently, the endocannabinoid system was discovered, which is made up of receptors, ligands and enzymes that are widely expressed in the brain and its periphery, where they act to maintain balance in several homeostatic processes. Exogenous cannabinoids or naturally-occurring phytocannabinoids interact with the endocannabinoid system. Marijuana must be processed in a laboratory to extract tetrahydrocannabinol and leave cannabidiol, which is the product that can be marketed. Some studies suggest cannabidiol has great potential for therapeutic use as an agent with antiepileptic, analgesic, anxiolytic, antipsychotic, anti-inflammatory and neuroprotective properties; however, the findings on cannabinoids efficacy and cannabis-based medications tolerability-safety for some conditions are inconsistent. More scientific evidence is required in order to generate recommendations on the use of medicinal cannabis.

PMID: 31695229 [PubMed – in process]


https://www.ncbi.nlm.nih.gov/pubmed/31695229?dopt=Abstract

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/erss.cgi?rss_guid=1BE6Yf6ex8r6DRZaKzQi_iKP-GeW6jP4zTLhuJ2dzIMGHW_IGQ
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Hemp employers fined for workplace safety hazards

Hemp employers fined for workplace safety hazards
In a series of related enforcement actions, Oregon Occupational Safety and Health Administration has fined multiple employers a total of $825,000 for …

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November 7, 2019 7:17 pm
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