POSTER SESSION: ALTERNATIVES TO MAMMALIAN MODELS I |
“Lessons Learned in Establishing a Reliable and Low-Cost Assay for Urea Production in Human Primary Hepatocytes Cultured in a Liver Chip for the Study of Drug Hepatotoxicity” |
Shi, Q. |
DSB |
POSTER SESSION: ALTERNATIVES TO MAMMALIAN MODELS I |
“AnimalGAN: A Generative AI Alternative to Animal Clinical Pathology Testing” |
Chen, X. |
DBB |
POSTER SESSION: ALTERNATIVES TO MAMMALIAN MODELS I |
“Cardiotoxicity Assessment of HESI Reference Compounds Using Human iPSC-CMs” |
Bagam, P. |
DSB |
POSTER SESSION: ALTERNATIVES TO MAMMALIAN MODELS I |
“Performance of the Three-Dimensional HepaRG Micronucleus Assay for In Vitro Genotoxicity Testing” |
Guo, X. |
DGMT |
POSTER SESSION: EPIDEMIOLOGY AND PUBLIC HEALTH |
“A Systematic Analysis and Data Mining of Opioid-Related Adverse Events Submitted to the FAERS Database” |
Le, H. |
DBB |
POSTER SESSION: EPIDEMIOLOGY AND PUBLIC HEALTH |
“Assessment of Modified Sandwich Estimator for Generalized Estimating Equations with Application to Opioid Poisoning in MIMIC-IV ICU Patients” |
Rogers, P. |
DBB |
POSTER SESSION: EPIDEMIOLOGY AND PUBLIC HEALTH |
“RxNorm for Drug Name Normalization: A Case Study of Prescription Opioids in the US FDA Adverse Events Reporting System” |
Zou, W. |
DBB |
POSTER SESSION: REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY I |
“Assessing the Developmental Toxicity of Busulfan in an In Vitro Human Placental Barrier-Embryo Co-culture System” |
Wang, Y. |
DGMT |
POSTER SESSION: CARCINOGENICITY |
“DNA Methylation and Transcriptomic Alterations Induced by Extended Treatment of Normal Human MCF10A Mammary Gland Epithelial Cells with Non-cytotoxic Doses of Lorcaserin” |
Willett, R. |
DBT |
PLATFORM SESSION: EXPLORING TIME AND CELL DIVERSITY IN TOXICOGENOMICS SPACE |
“Effect of Food-Grade Titanium Dioxide on DNA Methylation in Human Cells”
|
Wells, C. |
DBT |
WORKSHOP SESSION: UNDERSTANDING THE CONCEPT OF SIMILARITY AND ITS APPLICATIONS TO TOXICOLOGICAL RESEARCH AND RISK ASSESSMENT |
“Structure Similarity Based on Chemical Descriptors, Fingerprints, and Structural Alerts” |
Hong, H. |
DBB |
POSTER SESSION: DNA DAMAGE AND REPAIR |
“Evaluation of Newly Developed 14 Human TK6-Derived Cell Lines That Individually Express a Human Cytochrome P450 for Toxicity Studies” |
Mei, N. |
DGMT |
POSTER SESSION: DNA DAMAGE AND REPAIR |
“Nitrosamine Drug Impurities Induce Genotoxicity in Human Lymphoblastoid TK6 Cells” |
Li, X. |
DGMT |
POSTER SESSION: DNA DAMAGE AND REPAIR |
“Actein Contributes to Black Cohosh Extract-Induced Genotoxicity in Human TK6 Cells” |
Le, Y. |
DGMT |
POSTER SESSION: DNA DAMAGE AND REPAIR |
“Assessment of DNA Damage-Induced by 10 Nitrosamine Impurities Using 2D and 3D HepaRG Models” |
Seo, J.-E. |
DGMT |
POSTER SESSION: DNA DAMAGE AND REPAIR |
“Evaluation of the DNA Mutagenicity of N-hydroxycytidine in Mouse Lymphoma Cells by HiFi and Clone Sequencing” |
Revollo, J. |
DGMT |
POSTER SESSION: DNA DAMAGE AND REPAIR |
“HiFi Sequencing for Detecting In Vivo Somatic Mutation” |
Dobrovolsky, V. |
DGMT |
POSTER SESSION: DNA DAMAGE AND REPAIR |
“HiFi Sequencing Detects the On- and Off-Target Effects of a Cytosine-to-Thymine Base Editor in E. coli“ |
Miranda, J. |
DGMT |
POSTER SESSION: BIOTRANSFORMATION/CYTOCHROME P450 |
“Study of the Roles of Cytochrome P450 (CYPs) in the Metabolism and Cytotoxicity of Perhexiline” |
Chen, S. |
DBT |
POSTER SESSION: COMPUTATIONAL TOXICOLOGY I |
“Using Language Model to Facilitate COVID-19-Associated Neurological Disorder Literature Analysis: A BERTox Research” |
Wu, L. |
DBB |
POSTER SESSION: COMPUTATIONAL TOXICOLOGY I |
“Development of Random Forest Model for Predicting SARS-CoV-2 Main Protease Binders as Potential Candidates for Repurposing to COVID-19 Treatment” |
Xu, L. |
DBB |
POSTER SESSION: COMPUTATIONAL TOXICOLOGY I |
“Opioid Agonist/Antagonist Database (OADB): A Database to Facilitate Opioid Drug Development” |
Dong, F. |
DBB |
POSTER SESSION: COMPUTATIONAL TOXICOLOGY I |
“Machine Learning Models for Rat Multigeneration Reproductive Toxicity Prediction” |
Liu, J. |
DBB |
POSTER SESSION: COMPUTATIONAL TOXICOLOGY II |
“Machine Learning for Predicting Risk of Drug-Induced Autoimmune Diseases by Structural Alerts and Daily Dose” |
Chen, M. |
DBB |
POSTER SESSION: SYSTEMS BIOLOGY |
“Assessment of the Toxicity of Cannabidiol (CBD) in Rats upon Oral Developmental Exposure” |
Camacho, L. |
DBT |
POSTER SESSION: REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY III |
“Cannabidiol-Induced Transcriptomic Changes and Cellular Senescence in Human Sertoli Cells” |
Li, Y. |
DBT |
POSTER SESSION: REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY III |
“COVID-19 Effects on Pregnancy, Prenatal, and Postnatal Development” |
Bidarimath, M. |
DSB |
POSTER SESSION: SAFETY ASSESSMENT: PHARMACEUTICAL-DRUG DEVELOPMENT II |
“Obtain Drug Safety Rankings through Meta-analysis of Clinical Trial Data Using Penalized Bayesian Model” |
Wang, D. |
DBB |
POSTER SESSION: BIOMARKERS |
“T2-MRI Mapping as a Minimally Invasive Correlate of Central Nervous System (CNS) Toxicity in a Cuprizone Model: A Biomarker Study” |
Imam, S. |
DNT |
POSTER SESSION: EPIGENETICS |
“Effect of the Weight-Loss Drug Lorcaserin on DNA Methylation in Mammary Glands of Sprague Dawley Rats” |
Roudachevski, I. |
DBT |
PLATFORM SESSION: ENHANCING TOXICOLOGY WITH MACHINE LEARNING |
“PathologAI – A Deep Learning Framework for Whole Slide Classification in Preclinical Pathology” |
Xu, J. |
DBB |
POSTER SESSION: ALTERNATIVES TO MAMMALIAN MODELS II Chair: Qiang Shi (DSB) |
“Whole Genome Sequencing Analysis of Mutagenicity of N-Nitrosodiethylamine Using Caenorhabditis elegans Models” |
Chen, T. |
DGMT |
POSTER SESSION: BIOINFORMATICS |
“Deep Learning-Based Genotype Imputation for Enhancing Toxicogenomic Data” |
Song, M. |
DBB |
POSTER SESSION: BIOINFORMATICS |
“Statistical Methods for Exploring Spontaneous Adverse Event Reporting Databases for Drug-Host Factor Interactions” |
Lu, Z. |
DBB |
POSTER SESSION: BIOINFORMATICS |
“Development of a Large List of Drugs for the Study of Nephrotoxicity in Drug Discovery” |
Connor, S. |
DBB |
POSTER SESSION: BIOINFORMATICS |
“Random Forest Model for Predicting μ Opioid Receptor Binding Activity for Assisting Development of Opioid Drugs” |
Li, Z. |
DBB |
POSTER SESSION: BIOINFORMATICS |
“DeepAmes: Deep Learning-Powered Ames Test Prediction Using Model-Level Representation” |
Li, T. |
DBB |
POSTER SESSION: RISK ASSESSMENT II |
“Informing Selection of Drugs for COVID-19 Treatment through Analysis of Adverse Events” |
Guo, W. |
DBB |
POSTER SESSION: NEUROTOXICITY: DEVELOPMENTAL I |
“Cytokine-Mediated Chemotherapy-Induced Cognitive Impairment in Cisplatin and Methotrexate Treated Sprague Dawley Rats” |
Yeary, J. |
DNT |
POSTER SESSION: NEUROTOXICITY: DEVELOPMENTAL I |
“Examining Immune Modulatory Effects of Perinatal Cannabidiol Exposure in Sprague Dawley Rats” |
Gill, W. |
DNT |
POSTER SESSION: NEUROTOXICITY: DEVELOPMENTAL I |
“The Neurotoxic Potential of a Single Dose of Ketamine in Adolescent and Adult Rats” |
Talpos, J. |
DNT |
POSTER SESSION: NEUROTOXICITY: DEVLEOPMENTAL II |
“Behavioral Effects of Cisplatin and Methotrexate Treatment in Juvenile Sprague Dawley Rats” |
Flanigan, T. |
DNT |
POSTER SESSION: NEUROTOXICITY: DEVLEOPMENTAL II |
“Investigation of the Developmental Neurotoxicity of Opioids Using Human-Induced Pluripotent Stem Cells” |
Cai, C. |
DSB |
POSTER SESSION: NEUROTOXICITY: GENERAL |
“A Modified Approach of Fluoro-Jade C Labeling for Neurotoxicity Assessments” |
Gu, Q. |
DNT |
POSTER SESSION: IMMUNOTOXICITY I |
“Sex-Based Differences in Inflammatory Responses to Silver Nanoparticles” |
Canup, B. |
DBT |
WORKSHOP SESSION 1195: MOVING STEM CELL-DERIVED NEW APPROACH METHODS TOWARD REGULATORY ACCEPTANCE Chair: Li Pang (DSB) |
“Predicting Interindividual Variability of Doxorubicin Cardiotoxicity with Induced Pluripotent Stem Cell-Derived Cardiomyocytes” |
Pang, L. |
DSB |
POSTER SESSION: BIOLOGICAL MODELING |
“A Multiscale Physiologically Based Pharmacokinetic (PBPK) Model to Predict the Plasma Concentration and the Tissue Distribution of Doxorubicin” |
Li, M. |
DBT |
POSTER SESSION: BIOLOGICAL MODELING |
“Using Various Machine-Learning Algorithms to Determine the Best Method for Predicting Population Physiologically Based Pharmacokinetic Model Plasma Profiles” |
Fairman, K. |
DBT |
POSTER SESSION: KIDNEY |
“Evaluating Renal Pathology in Post-COVID-19 Human Autopsy Tissues” |
Masters, E. |
DSB |
POSTER SESSION: SKIN AND DERMAL TOXICITY |
“Parallel Evaluation of Alternative Skin Barrier Models and Excised Human Skin for Dermal Absorption Studies In Vitro” |
Salminen, A. |
DBT |
POSTER SESSION: LIVER I: IN VIVO Chair: Si Chen (DBT) |
“Gene Expression Changes Predict the Severity of NAFLD-Like Liver Injury in Male Collaborative Cross Mice” |
Tryndyak, V. |
DBT |
POSTER SESSION: LIVER II: IN VIVO |
“hnRNP-Q and hnRNP-L Influence Drug Metabolism and Toxicity by Regulating mRNA Processing of Drug Metabolizing Enzymes and Nuclear Receptors in HepaRG Cells” |
Li, D. |
DBB |
POSTER SESSION: LIVER II: IN VIVO |
“hnRMP-Q and hnRMP-L Influence Drug Metabolism and Toxicity by Regulating mRNA Processing of Drug Metabolizing Enzymes and Nuclear Receptors in HepaRG Cells” |
Li, D. |
DBB |
POSTER SESSION: RESPIRATORY TOXICOLOGY I |
“Establishing a Continuous Aerosol Exposure Method for Evaluating the Respiratory Toxicity of Ortho-Phthalaldehyde” |
Sun, Y. |
DGMT |
POSTER SESSION: LATE-BREAKING 2-4 |
“Potential Link of High-Fat Diet on the Expression of Alzheimer’s Disease-Related Genes in the Ileal Mucosa of Alzheimer’s Disease Model of Rats” |
Karn, K. |
DM |
POSTER SESSION: LATE-BREAKING 2-4 |
“The Effects of Cannabidiol and Its Main Metabolites on Human Neural Stem Cells” |
Latham, L. |
DNT |
POSTER SESSION: LATE-BREAKING 2-4 |
“Comparison of the Effects of Delta-9 Tetrahydrocannabinol and Cannabidiol on Human Neural Stem Cells” |
Liu, F. |
DNT |
POSTER SESSION: LATE-BREAKING 2-4 |
“Assessment of Potential Developmental Neurotoxicity of Purified Cannabidiol in Sprague Dawley Rats” |
Shen, A. |
DNT |