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Antipsychotic potential of the type 1 cannabinoid receptor positive allosteric modulator GAT211: preclinical in vitro and in vivo studies.

Antipsychotic potential of the type 1 cannabinoid receptor positive allosteric modulator GAT211: preclinical in vitro and in vivo studies.

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Antipsychotic potential of the type 1 cannabinoid receptor positive allosteric modulator GAT211: preclinical in vitro and in vivo studies.

Psychopharmacology (Berl). 2021 Jan 13;:

Authors: McElroy DL, Roebuck AJ, Scott GA, Greba Q, Garai S, Denovan-Wright EM, Thakur GA, Laprairie RB, Howland JG

Abstract
RATIONALE: Antipsychotics help alleviate the positive symptoms associated with schizophrenia; however, their debilitating side effects have spurred the search for better treatment options. Novel compounds can be screened for antipsychotic potential in neuronal cell cultures and following acute N-methyl-D-aspartate (NMDA) receptor blockade with non-competitive antagonists such as MK-801 in rodent behavioral models. Given the known interactions between NMDA receptors and type 1 cannabinoid receptors (CB1R), compounds that modulate CB1Rs may have therapeutic potential for schizophrenia.
OBJECTIVES: This study assessed whether the CB1R positive allosteric modulator GAT211, when compared to ∆9-tetrahydrocannabinol (THC), has potential to reduce psychiatric behavioral phenotypes following acute MK-801 treatment in rats, and block hyperdopaminergic signalling associated with those behaviors.
METHODS: The effects of GAT211 and THC on cellular signaling were compared in Neuro2a cells, and behavioral effects of GAT211 and THC on altered locomotor activity and prepulse inhibition of the acoustic startle response caused by acute MK-801 treatment were assessed in male, Long Evans rats.
RESULTS: GAT211 limited dopamine D2 receptor-mediated extracellular regulated kinase (ERK) phosphorylation in Neuro2a cells, whereas THC did not. As expected, acute MK-801 (0.15 mg/kg) produced a significant increase in locomotor activity and impaired PPI. GAT211 treatment alone (0.3-3.0 mg/kg) dose-dependently reduced locomotor activity and the acoustic startle response. GAT211 (3.0 mg/kg) also prevented hyperlocomotion caused by MK-801 but did not significantly affect PPI impairments.
CONCLUSION: Taken together, these findings support continued preclinical research regarding the usefulness of CB1R positive allosteric modulators as antipsychotics.

PMID: 33442771 [PubMed – as supplied by publisher]

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Why CBD

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Development of Stimuli-Responsive Chitosan/ZnO NPs Transdermal Systems for Controlled Cannabidiol Delivery.

Development of Stimuli-Responsive Chitosan/ZnO NPs Transdermal Systems for Controlled Cannabidiol Delivery.

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Development of Stimuli-Responsive Chitosan/ZnO NPs Transdermal Systems for Controlled Cannabidiol Delivery.

Polymers (Basel). 2021 Jan 08;13(2):

Authors: Radwan-Pragłowska J, Janus Ł, Piątkowski M, Sierakowska A, Szajna E, Matýsek D, Bogdał D

Abstract
One of the most common neurological diseases is epilepsy, which not only negatively affects the quality of people’s life but also may lead to life-threatening situations when its symptoms such as seizures cannot be controlled medically. A very serious problem to be overcame is the untreatable form of this disease, which cannot be cured by any currently available medicines. Cannabidiol, which is a natural product obtained from Cannabis Sativa, brings a new hope to people suffering from drug-resistant epilepsy. However, the hydrophobic character of this compound significantly lowers its clinical efficiency. One of the promising methods of this substance bioactivity increase is delivery through the skin tissue. In this article, a new type of advanced transdermal systems based on chitosan and ZnO nanoparticles (NPs) has been developed according to Sustained Development principles. The chemical modification of the biopolymer confirmed by FT-IR method resulted in the preparation of the material with great swelling abilities and appropriate water vapor permeability. Obtained nanoparticles were investigated over their crystalline structure and morphology and their positive impact on drug loading capacity and cannabidiol controlled release was proved. The novel biomaterials were confirmed to have conductive properties and not be cytotoxic to L929 mouse fibroblasts.

PMID: 33435623 [PubMed]

#CBD #Hemp https://www.ncbi.nlm.nih.gov/pubmed/33435623?dopt=Abstract

Filtered by tag "CBD"

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Development and validation of a LC-HRMS method for the quantification of cannabinoids and their metabolites in human plasma.

Development and validation of a LC-HRMS method for the quantification of cannabinoids and their metabolites in human plasma.

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Eur J Pharm Sci. 2021 Jan 09;:105705

Authors: Mohamed MK, Takyi-Williams J, Baudot B, Grobler A

Abstract
The resurgence of Cannabis therapeutic discoveries have led to the need for sensitive and selective analytical methods for the detection of cannabinoids and their metabolites in biological matrices. High resolution mass spectrometry (HRMS) enables good sensitivity and provides more selectivity due to its accurate mass measurement of the targeted compounds. The aim of this study was to develop and validate a sensitive liquid chromatography high resolution mass spectrometry (LC-HRMS) method for the quantitative analysis of cannabidiol (CBD), cannabinol (CBN), Δ9-tetrahydrocannabinol (Δ9-THC) and its major metabolites 11-Hydroxy-Δ9-THC and 11-Nor-9-carboxy-Δ9-THC in human plasma. The method utilized a simple liquid-liquid extraction of the cannabinoids from plasma samples followed by an isocratic chromatographic separation and detection by ESI-HRMS Q-Exactive plus platform. The lower limit of quantification (LLOQ) was 0.2 ng/ mL for the targeted cannabinoids and its metabolites with sample volume of 0.5 mL plasma. The method was linear from 0.2 to 100.0 ng/mL with an average correlation coefficient of >0.995 using weighted (1/x) linear least-squares regression. No significant carry-over was noticed for all analytes and the extraction recovery ranged from 60.4 % to 85.4 %. Dilution results indicated no influence on the accuracy of analysis. The method’s intra-day and inter-day precision (CV %) ranged from 2.90 to 10.80 % and accuracy within -0.9 to 7.0 from nominal. Matrix effect ranged from 1.1 % to 49.8 %. The analytes were stable in the autosampler for 6 and 12 h, respectively. This method was sensitive and can be applicable to cannabinoids pharmacokinetics study.

PMID: 33434601 [PubMed – as supplied by publisher]

#CBD #Hemp https://www.ncbi.nlm.nih.gov/pubmed/33434601?dopt=Abstract

Cannabis alleviates neuropathic pain and reverses weight loss in diabetic neuropathic cachexia in a previous heroin abuser.

Cannabis alleviates neuropathic pain and reverses weight loss in diabetic neuropathic cachexia in a previous heroin abuser.

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Cannabis alleviates neuropathic pain and reverses weight loss in diabetic neuropathic cachexia in a previous heroin abuser.

Endocrinol Diabetes Metab Case Rep. 2020 Oct 14;2020:

Authors: Naccache DD

Abstract
Summary: Ten years after the successful withdrawal from heroin abuse, a person with diabetes suffered intractable pain and severe muscular emaciation consistent with the syndrome of diabetic neuropathic cachexia. Anti-neuropathic medications failed neither to alleviate suffering and reverse weight loss, nor to stop muscular emaciation. Vigilant evaluation for weight loss aetiologies revealed no responsible aetiology. Prescribing medical cannabis became mandatory, with the intention to alleviate neuropathic pain, regain muscular mass and strengthen legs, enable standing upright and walking normally. Medical cannabis for pain-relief, and the orexigenic properties of tetrahydrocannabinol (THC) ingredient successfully achieved these goals.
Learning points: Medical cannabis can serve to promptly alleviate severe diabetic neuropathic pain. Past history of heroin abuse was not an absolute contraindication to medical cannabis use. Medical cannabis increased appetite and reversed muscular emaciation. Medical cannabis decreased chronic pain and hence, its catabolic consequences.

PMID: 33434166 [PubMed – as supplied by publisher]

#CBD #Hemp https://www.ncbi.nlm.nih.gov/pubmed/33434166?dopt=Abstract

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Why Is My Cbd Oil Crystallizing

Why Is My Cbd Oil Crystallizing Isolate: CBD isolate is cannabidiol in its purest form: a fine white powder. A study from the 1990s suggested that some THC might be lost in the water, but … #CBD #Hemp https://www.google.com/url?rct=j&sa=t&url=http://yjhb.lasersmagliature.it/why-is-my-cbd-oil-crystallizing.html&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNG0hD5OUleM72_GKxRWC47lsjNfYg January 12, 2021 9:04 pm

Plain Naturals Launches Maximum Strength CBD Products

Plain Naturals Launches Maximum Strength CBD Products This contains 5000mg cannabidiol per 30ml or 1oz of oil. This means that a recommended dose of 1ml has over 150mg of CBD. In the last year, there … #CBD #Hemp https://www.google.com/url?rct=j&sa=t&url=https://www.einnews.com/pr_news/534412889/plain-naturals-launches-maximum-strength-cbd-products&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNGfvvdmn7TFXD-gcr9YDsUenQdxPA January 12, 2021 8:26 pm

USDA Approves Hemp Regulatory Proposals For Rhode Island, Soboba Band of Luiseno Indians

USDA Approves Hemp Regulatory Proposals For Rhode Island, Soboba Band of Luiseno Indians The legalization of hemp and its derivatives took place a couple of years ago under the 2018 Farm Bill. Since then, the USDA has been reviewing and … #CBD #Hemp https://www.google.com/url?rct=j&sa=t&url=https://www.benzinga.com/markets/cannabis/21/01/19129618/usda-approves-hemp-regulatory-proposals-for-rhode-island-soboba-band-of-luiseno-indians&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNG3fv3Ak-nEEZaOXjVoY8-d66V_xA January 12, 2021 8:15 pm

5 Generation Bakers and Hemp Synergistics form local partnership to serve new CBD product line …

5 Generation Bakers and Hemp Synergistics form local partnership to serve new CBD product line … Each baked good, which for now consists of either a CBD chocolate chip cookie or a CBD brownie cake, retails for $3.95 individually or in packs of 12 … #CBD #Hemp https://www.google.com/url?rct=j&sa=t&url=https://www.bizjournals.com/pittsburgh/news/2021/01/12/local-hemp-baked-goods-manufacturers-team-up.html&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNHWiLJPWC7ODRMBJTYi0dbEACzyfw January 12, 2021 7:52 pm

Places In South Carolina That Sell Legal Cbd Hemp Flower

Places In South Carolina That Sell Legal Cbd Hemp Flower CBD, along with several other cannabinoids and terpenes also contained in highgrade CBD creams activate these receptors to reduce the level of … #CBD #Hemp https://www.google.com/url?rct=j&sa=t&url=http://cscs.ng/Hemp/Places-In-South-Carolina-That-Sell-Legal-Cbd-Hemp-Flower_Ea009472.htm&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNEvg3tGFoxKbFlCNXJ_z-aOtq_Jbw January 12, 2021 7:14 pm

Charlotte's Web Secures US Utility Patents for Two New Hemp Varietals with Superior …

Charlotte's Web Secures US Utility Patents for Two New Hemp Varietals with Superior … (“Charlotte's Web” or the “Company”), the market leader in hemp CBD wellness products, announces that Charlotte's Web, Inc., a wholly-owned … #CBD #Hemp https://www.google.com/url?rct=j&sa=t&url=https://www.prnewswire.com/news-releases/charlottes-web-secures-us-utility-patents-for-two-new-hemp-varietals-with-superior-cannabinoid-expression-301206788.html&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNHYNWa8H_dm3kQXDGxaC8iPD7Sqqw January 12, 2021 6:45 pm

New industry group in Spain aims to change government's flower opposition

New industry group in Spain aims to change government's flower opposition That means that “the extraction of the cannabidiol CBD is only permitted from the seeds of hemp,” according to an email the ministry sent to Hemp … #CBD #Hemp https://www.google.com/url?rct=j&sa=t&url=https://hempindustrydaily.com/new-industry-group-in-spain-aims-to-change-governments-flower-opposition/&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNG5mln5Zxou89PBpdQfbcmVrqkxMg January 12, 2021 5:37 pm

Five Generation Bakers teams with Pennsylvania hemp company for CBD baked goods line

Five Generation Bakers teams with Pennsylvania hemp company for CBD baked goods line The edibles are free of hemp's bitter taste, as the Jenny Lee formulated recipes utilize Hemp Synergistics' Hemp Bake Mix, a first-of-its-kind free flowing … #CBD #Hemp https://www.google.com/url?rct=j&sa=t&url=https://www.bakemag.com/articles/14242-five-generation-bakers-teams-with-pennsylvania-hemp-company-for-cbd-baked-goods-line&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNGj5Mt_bCTTQWYeVpxAZ3HsBHMH8g January 12, 2021 4:41 pm

USDA Approves Hemp Regulatory Plans From Rhode Island And Another Indian Tribe

USDA Approves Hemp Regulatory Plans From Rhode Island And Another Indian Tribe While the agency released an interim final rule for a domestic hemp production program in 2019, industry stakeholders and lawmakers have expressed … #CBD #Hemp https://www.google.com/url?rct=j&sa=t&url=https://www.marijuanamoment.net/usda-approves-hemp-regulatory-plans-from-rhode-island-and-another-indian-tribe/&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNFLtKChDkAZ5AKrX8kYBH33aAXyFQ January 12, 2021 4:18 pm

Matthew turns to Golfer's CBD in pursuit of further success

Matthew turns to Golfer's CBD in pursuit of further success CBD is short for cannabidiol, one of 113 cannabinoids identified by scientific research into the cannabis plant. As long as the illegal cannabinoids are … #CBD #Hemp https://www.google.com/url?rct=j&sa=t&url=https://www.golfretailing.com/news/matthew-turns-to-golfers-cbd-in-pursuit-of-further-success/&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNFCI8pblLVuiF2zDYB5nmF1TveBXg January 12, 2021 4:09 pm

CBDNewsBreaks – HempFusion Wellness Inc. (TSX: CBD.U) Becomes One of First Publicly …

CBDNewsBreaks – HempFusion Wellness Inc. (TSX: CBD.U) Becomes One of First Publicly … HempFusion is one of the first publicly traded CBD companies to receive the certification; the distinction is significant because organic products … #CBD #Hemp https://www.google.com/url?rct=j&sa=t&url=https://www.streetinsider.com/Investor%2BBrand%2BNetwork/CBDNewsBreaks%2B%25E2%2580%2593%2BHempFusion%2BWellness%2BInc.%2B%2528TSX%253A%2BCBD.U%2529%2BBecomes%2BOne%2Bof%2BFirst%2BPublicly%2BTraded%2BCompanies%2Bto%2BReceive%2BUSDA%2BOrganic%2BCertification%2Bfor%2BCBD%2BTinctures/17813048.html&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNHO2yCJmXGUZs9zJGfTjIpe0FIglg January 12, 2021 4:07 pm

Compliance Experts Specializing in Hemp, CBD and THC-Cannabis Launch New Psilocybin Division

Compliance Experts Specializing in Hemp, CBD and THC-Cannabis Launch New Psilocybin Division “Even if psilocybin sales are a couple of years away, as the cannabis and hemp industries have taught us, having regulatory compliance baked into the … #CBD #Hemp https://www.google.com/url?rct=j&sa=t&url=https://www.northwestgeorgianews.com/associated_press/business/compliance-experts-specializing-in-hemp-cbd-and-thc-cannabis-launch-new-psilocybin-division/article_357c78d1-ed14-5f11-aa01-67487715ae76.html&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNF_l-S3py8FLTMMM3aAz6fpfBqudg January 12, 2021 3:56 pm

Learn the ABC's of CBD with Karen and Ryan, owners of Green Balance Hemp & Wellness.

Learn the ABC's of CBD with Karen and Ryan, owners of Green Balance Hemp & Wellness. Karen and Ryan are both NWI natives who became introduced to hemp and CBD while spending some time in California. When they moved back to … #CBD #Hemp https://www.google.com/url?rct=j&sa=t&url=https://digthedunes.com/learn-the-abcs-of-cbd-with-karen-and-ryan-owners-of-green-balance-hemp-wellness/&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNHXpqJb8Y0XaeRa_6rqLEeDdKsyYw January 12, 2021 3:50 pm

California lawsuit over hemp destruction on hold

California lawsuit over hemp destruction on hold A federal judge in California has tapped the brakes on a lawsuit from a hemp grower who saw the state's Department of Fish and Wildlife bulldoze 500 … #CBD #Hemp https://www.google.com/url?rct=j&sa=t&url=https://hempindustrydaily.com/california-lawsuit-over-hemp-destruction-on-hold/&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNEhLe_9TNbE539fVaR3kwYWgpJIKQ January 12, 2021 3:45 pm

FDA Regulation of CBD Requires Filling “Knowledge Gaps”

FDA Regulation of CBD Requires Filling “Knowledge Gaps” released a statement entitled “Better Data for a Better Understanding of the Use and Safety Profile of Cannabidiol (CBD) Products”, which details the “ … #CBD #Hemp https://www.google.com/url?rct=j&sa=t&url=https://www.natlawreview.com/article/fda-regulation-cbd-requires-filling-knowledge-gaps&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNGpUfgZc4mAlx7hgWq3uDyhsCidlg January 12, 2021 3:45 pm

The Future Of Smokable CBD Products Is Not Great

The Future Of Smokable CBD Products Is Not Great The last few years have been a wild ride for the United States' hemp-derived cannabidiol (CBD) industry. Ever since the Food and Drug Administration ( … #CBD #Hemp https://www.google.com/url?rct=j&sa=t&url=https://thefreshtoast.com/cbd/the-future-of-smokable-cbd-products-is-not-great/&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNEGZ9Dgic–M7kUtTr2CYuIve6uWg January 12, 2021 3:27 pm

Catriona Matthew is latest golf star to use CBD to calm nerves

Catriona Matthew is latest golf star to use CBD to calm nerves The Solheim Cup captain has joined fellow major winners Bubba Watson and Lucas Glover in turning to CBD, which is short for cannabidiol, to help … #CBD #Hemp https://www.google.com/url?rct=j&sa=t&url=https://www.scotsman.com/sport/golf/catriona-matthew-latest-golf-star-use-cbd-calm-nerves-3093599&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNGcALaNxKquQCFLnLeO15DVwylQ-A January 12, 2021 3:22 pm

GVB Biopharma Sets Industry Precedent with CCOF Certification

GVB Biopharma Sets Industry Precedent with CCOF Certification Organic certification of any kind is rare in the hemp industry. CCOF's registry indicates that GVB Biopharma is one of a select few CBD producers to … #CBD #Hemp https://www.google.com/url?rct=j&sa=t&url=https://www.prnewswire.com/news-releases/gvb-biopharma-sets-industry-precedent-with-ccof-certification-301205766.html&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNHAvs3hvyzjefeBea6BRVqpISKYJA January 12, 2021 3:11 pm

Is Drinking CBD a Good or Bad Idea?

Is Drinking CBD a Good or Bad Idea? We have heard almost everything about CBD—or cannabidiol, the molecule found in cannabis. Used for more than two millennia for its therapeutic … #CBD #Hemp https://www.google.com/url?rct=j&sa=t&url=https://www.lofficielusa.com/fashion/benefits-drinking-cbd-cannabidiol&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNE8K18IR713n9Xbzj-NDh0umWx34Q January 12, 2021 3:00 pm

Cannabidiol use during pregnancy affects the brain and behavior in adulthood

Cannabidiol use during pregnancy affects the brain and behavior in adulthood The use of cannabidiol (CBD), the major non-psychoactive compound in cannabis, is on the rise across the United States. Pregnant women in … #CBD #Hemp https://www.google.com/url?rct=j&sa=t&url=https://twin-cities.umn.edu/news-events/cannabidiol-use-during-pregnancy-affects-brain-and-behavior-adulthood&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNGzYKUdFOHV6QFTFMHkSjR8y3imqQ January 12, 2021 2:48 pm

With Growing Demand, the CBD Market Could be Worth $16 Billion by 2025

With Growing Demand, the CBD Market Could be Worth $16 Billion by 2025 (TSX:CBD.U) BREAKING NEWS: HempFusion Wellness Inc., a leading health and wellness CBD company utilizing the power of whole-food hemp … #CBD #Hemp https://www.google.com/url?rct=j&sa=t&url=https://www.baystreet.ca/stockstowatch/9496/With-Growing-Demand-the-CBD-Market-Could-be-Worth-16-Billion-by-2025&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNHKJ0_Gg4cvMGuiDu-_c5-IqzbNbA January 12, 2021 2:15 pm

What's Happening in the 'Canopy Growth v. GW Pharmaceuticals' Lawsuit?

What's Happening in the 'Canopy Growth v. GW Pharmaceuticals' Lawsuit? A process for producing an extract containing Tetrahydrocannabinol (THC) and/or cannabidiol (CBD), and optionally the carboxylic acid thereof, from … #CBD #Hemp https://www.google.com/url?rct=j&sa=t&url=https://www.hempgrower.com/article/canopy-growth-gw-pharmaceuticals-lawsuit-extraction/&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNEUL6Vngp7_Igaw8oG933TxrMN0jA January 12, 2021 2:15 pm

Generation Hemp Announces Closing of the Acquisition of Halcyon Thruput, LLC for ~$5.1 Million

Generation Hemp Announces Closing of the Acquisition of Halcyon Thruput, LLC for ~$5.1 Million Generation Hemp, Inc. (OTCPK: GENH), a Dallas-based Hemp company, announced today that it has completed the previously announced … #CBD #Hemp https://www.google.com/url?rct=j&sa=t&url=https://finance.yahoo.com/news/generation-hemp-announces-closing-acquisition-140000919.html&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNEFqxJa_6qAQTgzxQ6-6rh4rOz1Mw January 12, 2021 2:03 pm

CBDgateways.com, a New but Experienced Online Payments Player, Enters the CBD Payment …

CBDgateways.com, a New but Experienced Online Payments Player, Enters the CBD Payment … With the launch of their new website, CBDgateways.com, the company aims to better serve US-based online CBD and hemp business owners by … #CBD #Hemp https://www.google.com/url?rct=j&sa=t&url=https://www.prnewswire.com/news-releases/cbdgatewayscom-a-new-but-experienced-online-payments-player-enters-the-cbd-payment-processing-arena-for-2021-301206451.html&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNHFSTCn0WvF3hjtmvOa10MKkMVv5g January 12, 2021 1:52 pm

357 Hemp Logistics First to Include Complimentary $50000 Hemp Cargo Insurance on Shipments …

357 Hemp Logistics First to Include Complimentary $50000 Hemp Cargo Insurance on Shipments … “It is imperative that the hemp industry recognizes transportation as an essential expense that can be extremely risky even though hemp is now legal,” … #CBD #Hemp https://www.google.com/url?rct=j&sa=t&url=https://www.globenewswire.com/news-release/2021/01/12/2157118/0/en/357-Hemp-Logistics-First-to-Include-Complimentary-50-000-Hemp-Cargo-Insurance-on-Shipments-Adds-Logistics-Expert-Jeremy-Powers-to-Leadership-Team.html&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNH6-nsr-k05NVs3cTdTwEmBMw2AMA January 12, 2021 1:41 pm

Gaia's Company Name Announces Availability of PET CBD TINCTURE

Gaia's Company Name Announces Availability of PET CBD TINCTURE For cats, CBD oil is an all-natural remedy that uses the therapeutic properties of hemp-derived compounds to support overall health and wellness. The … #CBD #Hemp https://www.google.com/url?rct=j&sa=t&url=https://www.prnewswire.com/news-releases/gaias-company-name-announces-availability-of-pet-cbd-tincture-301206228.html&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNHkJtjvXUOALO1CwSEyIFKw2Pla0A January 12, 2021 1:30 pm

AgEagle Aerial Systems Announces State of Iowa Chooses HempOverview for Managing …

AgEagle Aerial Systems Announces State of Iowa Chooses HempOverview for Managing … Hemp is an exciting addition to the mix, especially for people who want to farm, but have little land at their disposal. I am hopeful that processors and … #CBD #Hemp https://www.google.com/url?rct=j&sa=t&url=https://www.globenewswire.com/news-release/2021/01/12/2157085/0/en/AgEagle-Aerial-Systems-Announces-State-of-Iowa-Chooses-HempOverview-for-Managing-Registration-and-Oversight-of-Hemp-Crops.html&ct=ga&cd=CAIyGjJiMjA4MDRjNzhiYTg2MWM6Y29tOmVuOlVT&usg=AFQjCNH0Us5u8fPOjI8mXu9OC4agoEhUaQ January 12, 2021 1:30 pm