NCTR Participation at 2023 SOT Annual Meeting

FDA: NCTR Participation at 2023 SOT Annual Meeting NCTR Participation at 2023 SOT Annual Meeting Anonymous (not verified) Wed, 02/21/2024 – 15:53

Detailed Description
SOT 62nd Annual Meeting and ToxExpo featured more than 70 scientific sessions, 2,000 presentations, 250 exhibitors, and 5,000 attendees

Audience

The SOT 62nd Annual Meeting and ToxExpo featured more than 70 scientific sessions, 2,000 presentations, 250 exhibitors, and 5,000 attendees.

 

2023 SOT Platform, Poster, or Workshop Sessions

Title

NCTR Author

NCTR Division

POSTER SESSION: ALTERNATIVES TO MAMMALIAN MODELS I “Lessons Learned in Establishing a Reliable and Low-Cost Assay for Urea Production in Human Primary Hepatocytes Cultured in a Liver Chip for the Study of Drug Hepatotoxicity” Shi, Q. DSB
POSTER SESSION: ALTERNATIVES TO MAMMALIAN MODELS I “AnimalGAN: A Generative AI Alternative to Animal Clinical Pathology Testing” Chen, X. DBB
POSTER SESSION: ALTERNATIVES TO MAMMALIAN MODELS I “Cardiotoxicity Assessment of HESI Reference Compounds Using Human iPSC-CMs” Bagam, P. DSB
POSTER SESSION: ALTERNATIVES TO MAMMALIAN MODELS I “Performance of the Three-Dimensional HepaRG Micronucleus Assay for In Vitro Genotoxicity Testing” Guo, X. DGMT
POSTER SESSION: EPIDEMIOLOGY AND PUBLIC HEALTH “A Systematic Analysis and Data Mining of Opioid-Related Adverse Events Submitted to the FAERS Database” Le, H. DBB
POSTER SESSION: EPIDEMIOLOGY AND PUBLIC HEALTH “Assessment of Modified Sandwich Estimator for Generalized Estimating Equations with Application to Opioid Poisoning in MIMIC-IV ICU Patients” Rogers, P. DBB
POSTER SESSION: EPIDEMIOLOGY AND PUBLIC HEALTH “RxNorm for Drug Name Normalization: A Case Study of Prescription Opioids in the US FDA Adverse Events Reporting System” Zou, W. DBB
POSTER SESSION: REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY I “Assessing the Developmental Toxicity of Busulfan in an In Vitro Human Placental Barrier-Embryo Co-culture System” Wang, Y. DGMT
POSTER SESSION: CARCINOGENICITY “DNA Methylation and Transcriptomic Alterations Induced by Extended Treatment of Normal Human MCF10A Mammary Gland Epithelial Cells with Non-cytotoxic Doses of Lorcaserin” Willett, R. DBT
PLATFORM SESSION: EXPLORING TIME AND CELL DIVERSITY IN TOXICOGENOMICS SPACE

“Effect of Food-Grade Titanium Dioxide on DNA Methylation in Human Cells”

Wells, C. DBT
WORKSHOP SESSION: UNDERSTANDING THE CONCEPT OF SIMILARITY AND ITS APPLICATIONS TO TOXICOLOGICAL RESEARCH AND RISK ASSESSMENT “Structure Similarity Based on Chemical Descriptors, Fingerprints, and Structural Alerts” Hong, H. DBB
POSTER SESSION: DNA DAMAGE AND REPAIR “Evaluation of Newly Developed 14 Human TK6-Derived Cell Lines That Individually Express a Human Cytochrome P450 for Toxicity Studies” Mei, N. DGMT
POSTER SESSION: DNA DAMAGE AND REPAIR “Nitrosamine Drug Impurities Induce Genotoxicity in Human Lymphoblastoid TK6 Cells” Li, X. DGMT
POSTER SESSION: DNA DAMAGE AND REPAIR “Actein Contributes to Black Cohosh Extract-Induced Genotoxicity in Human TK6 Cells” Le, Y. DGMT
POSTER SESSION: DNA DAMAGE AND REPAIR “Assessment of DNA Damage-Induced by 10 Nitrosamine Impurities Using 2D and 3D HepaRG Models” Seo, J.-E. DGMT
POSTER SESSION: DNA DAMAGE AND REPAIR “Evaluation of the DNA Mutagenicity of N-hydroxycytidine in Mouse Lymphoma Cells by HiFi and Clone Sequencing” Revollo, J. DGMT
POSTER SESSION: DNA DAMAGE AND REPAIR “HiFi Sequencing for Detecting In Vivo Somatic Mutation” Dobrovolsky, V. DGMT
POSTER SESSION: DNA DAMAGE AND REPAIR “HiFi Sequencing Detects the On- and Off-Target Effects of a Cytosine-to-Thymine Base Editor in E. coli Miranda, J. DGMT
POSTER SESSION: BIOTRANSFORMATION/CYTOCHROME P450 “Study of the Roles of Cytochrome P450 (CYPs) in the Metabolism and Cytotoxicity of Perhexiline” Chen, S. DBT
POSTER SESSION: COMPUTATIONAL TOXICOLOGY I “Using Language Model to Facilitate COVID-19-Associated Neurological Disorder Literature Analysis: A BERTox Research” Wu, L. DBB
POSTER SESSION: COMPUTATIONAL TOXICOLOGY I “Development of Random Forest Model for Predicting SARS-CoV-2 Main Protease Binders as Potential Candidates for Repurposing to COVID-19 Treatment” Xu, L. DBB
POSTER SESSION: COMPUTATIONAL TOXICOLOGY I “Opioid Agonist/Antagonist Database (OADB): A Database to Facilitate Opioid Drug Development” Dong, F. DBB
POSTER SESSION: COMPUTATIONAL TOXICOLOGY I “Machine Learning Models for Rat Multigeneration Reproductive Toxicity Prediction” Liu, J. DBB
POSTER SESSION: COMPUTATIONAL TOXICOLOGY II “Machine Learning for Predicting Risk of Drug-Induced Autoimmune Diseases by Structural Alerts and Daily Dose” Chen, M. DBB
POSTER SESSION: SYSTEMS BIOLOGY “Assessment of the Toxicity of Cannabidiol (CBD) in Rats upon Oral Developmental Exposure” Camacho, L. DBT
POSTER SESSION: REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY III “Cannabidiol-Induced Transcriptomic Changes and Cellular Senescence in Human Sertoli Cells” Li, Y. DBT
POSTER SESSION: REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY III “COVID-19 Effects on Pregnancy, Prenatal, and Postnatal Development” Bidarimath, M. DSB
POSTER SESSION: SAFETY ASSESSMENT: PHARMACEUTICAL-DRUG DEVELOPMENT II “Obtain Drug Safety Rankings through Meta-analysis of Clinical Trial Data Using Penalized Bayesian Model” Wang, D. DBB
POSTER SESSION: BIOMARKERS “T2-MRI Mapping as a Minimally Invasive Correlate of Central Nervous System (CNS) Toxicity in a Cuprizone Model: A Biomarker Study” Imam, S. DNT
POSTER SESSION: EPIGENETICS “Effect of the Weight-Loss Drug Lorcaserin on DNA Methylation in Mammary Glands of Sprague Dawley Rats” Roudachevski, I. DBT
PLATFORM SESSION: ENHANCING TOXICOLOGY WITH MACHINE LEARNING “PathologAI – A Deep Learning Framework for Whole Slide Classification in Preclinical Pathology” Xu, J. DBB
POSTER SESSION: ALTERNATIVES TO MAMMALIAN MODELS II
Chair: Qiang Shi (DSB)
“Whole Genome Sequencing Analysis of Mutagenicity of N-Nitrosodiethylamine Using Caenorhabditis elegans Models” Chen, T. DGMT
POSTER SESSION: BIOINFORMATICS “Deep Learning-Based Genotype Imputation for Enhancing Toxicogenomic Data” Song, M. DBB
POSTER SESSION: BIOINFORMATICS “Statistical Methods for Exploring Spontaneous Adverse Event Reporting Databases for Drug-Host Factor Interactions” Lu, Z. DBB
POSTER SESSION: BIOINFORMATICS “Development of a Large List of Drugs for the Study of Nephrotoxicity in Drug Discovery” Connor, S. DBB
POSTER SESSION: BIOINFORMATICS “Random Forest Model for Predicting μ Opioid Receptor Binding Activity for Assisting Development of Opioid Drugs” Li, Z. DBB
POSTER SESSION: BIOINFORMATICS “DeepAmes: Deep Learning-Powered Ames Test Prediction Using Model-Level Representation” Li, T. DBB
POSTER SESSION: RISK ASSESSMENT II “Informing Selection of Drugs for COVID-19 Treatment through Analysis of Adverse Events” Guo, W.  DBB
POSTER SESSION: NEUROTOXICITY: DEVELOPMENTAL I “Cytokine-Mediated Chemotherapy-Induced Cognitive Impairment in Cisplatin and Methotrexate Treated Sprague Dawley Rats” Yeary, J. DNT
POSTER SESSION: NEUROTOXICITY: DEVELOPMENTAL I “Examining Immune Modulatory Effects of Perinatal Cannabidiol Exposure in Sprague Dawley Rats” Gill, W. DNT
POSTER SESSION: NEUROTOXICITY: DEVELOPMENTAL I “The Neurotoxic Potential of a Single Dose of Ketamine in Adolescent and Adult Rats” Talpos, J. DNT
POSTER SESSION: NEUROTOXICITY: DEVLEOPMENTAL II “Behavioral Effects of Cisplatin and Methotrexate Treatment in Juvenile Sprague Dawley Rats” Flanigan, T. DNT
POSTER SESSION: NEUROTOXICITY: DEVLEOPMENTAL II “Investigation of the Developmental Neurotoxicity of Opioids Using Human-Induced Pluripotent Stem Cells” Cai, C. DSB
POSTER SESSION: NEUROTOXICITY: GENERAL “A Modified Approach of Fluoro-Jade C Labeling for Neurotoxicity Assessments” Gu, Q. DNT
POSTER SESSION: IMMUNOTOXICITY I “Sex-Based Differences in Inflammatory Responses to Silver Nanoparticles” Canup, B. DBT
WORKSHOP SESSION 1195: MOVING STEM CELL-DERIVED NEW APPROACH METHODS TOWARD REGULATORY ACCEPTANCE
Chair: Li Pang (DSB)
“Predicting Interindividual Variability of Doxorubicin Cardiotoxicity with Induced Pluripotent Stem Cell-Derived Cardiomyocytes” Pang, L. DSB
POSTER SESSION: BIOLOGICAL MODELING “A Multiscale Physiologically Based Pharmacokinetic (PBPK) Model to Predict the Plasma Concentration and the Tissue Distribution of Doxorubicin” Li, M. DBT
POSTER SESSION: BIOLOGICAL MODELING “Using Various Machine-Learning Algorithms to Determine the Best Method for Predicting Population Physiologically Based Pharmacokinetic Model Plasma Profiles” Fairman, K. DBT
POSTER SESSION: KIDNEY “Evaluating Renal Pathology in Post-COVID-19 Human Autopsy Tissues” Masters, E. DSB
POSTER SESSION: SKIN AND DERMAL TOXICITY “Parallel Evaluation of Alternative Skin Barrier Models and Excised Human Skin for Dermal Absorption Studies In Vitro” Salminen, A. DBT
POSTER SESSION: LIVER I: IN VIVO
Chair: Si Chen (DBT)
“Gene Expression Changes Predict the Severity of NAFLD-Like Liver Injury in Male Collaborative Cross Mice” Tryndyak, V. DBT
POSTER SESSION: LIVER II: IN VIVO “hnRNP-Q and hnRNP-L Influence Drug Metabolism and Toxicity by Regulating mRNA Processing of Drug Metabolizing Enzymes and Nuclear Receptors in HepaRG Cells” Li, D. DBB
POSTER SESSION: LIVER II: IN VIVO “hnRMP-Q and hnRMP-L Influence Drug Metabolism and Toxicity by Regulating mRNA Processing of Drug Metabolizing Enzymes and Nuclear Receptors in HepaRG Cells” Li, D. DBB
POSTER SESSION: RESPIRATORY TOXICOLOGY I “Establishing a Continuous Aerosol Exposure Method for Evaluating the Respiratory Toxicity of Ortho-Phthalaldehyde” Sun, Y. DGMT
POSTER SESSION: LATE-BREAKING 2-4 “Potential Link of High-Fat Diet on the Expression of Alzheimer’s Disease-Related Genes in the Ileal Mucosa of Alzheimer’s Disease Model of Rats” Karn, K. DM
POSTER SESSION: LATE-BREAKING 2-4 “The Effects of Cannabidiol and Its Main Metabolites on Human Neural Stem Cells” Latham, L. DNT
POSTER SESSION: LATE-BREAKING 2-4 “Comparison of the Effects of Delta-9 Tetrahydrocannabinol and Cannabidiol on Human Neural Stem Cells” Liu, F. DNT
POSTER SESSION: LATE-BREAKING 2-4 “Assessment of Potential Developmental Neurotoxicity of Purified Cannabidiol in Sprague Dawley Rats” Shen, A. DNT

 

Communication Type

Short Title
NCTR Participation at 2023 Society of Toxicology

Source Organization

Short Description
Society of Toxicology (SOT) Annual Meeting and ToxExpo, March 19-23, 2023

Publish Date
Wed, 02/21/2024 – 17:00

Review Date
Fri, 02/21/2025 – 00:00

Last Reviewed Date
Wed, 02/21/2024 – 00:00

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1 Year

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Wed, 02/21/2024 – 16:17

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